付麗園 吳智 諶麗華

[摘要]目的 探討泮托拉唑輔助治療消化性潰瘍合并上消化道出血的臨床效果。方法 選取2017年1～12月我院收治的100例消化性潰瘍合并上消化道出血患者作為研究對象，按照隨機數(shù)字表法將其分成兩組，分別為對照組（50例）和研究組（50例）。對照組患者給予奧美拉唑治療，研究組患者給予奧美拉唑聯(lián)合泮托拉唑輔助治療。比較分析兩組患者的臨床治療效果、治療前后不同時間的嘔血次數(shù)及黑便次數(shù)，比較兩組患者的并發(fā)癥發(fā)生情況。結(jié)果 研究組患者的臨床治療總有效率為96.00%，對照組患者的臨床治療總有效率為78.00%，研究組患者的臨床治療總有效率高于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。研究組患者治療前的嘔血次數(shù)為（2.98±1.21）次，黑便次數(shù)為（2.21±1.02）次，對照組患者治療前的嘔血次數(shù)為（3.02±1.20）次，黑便次數(shù)為（2.20±1.03）次，兩組治療前的嘔血次數(shù)、黑便次數(shù)比較，差異無統(tǒng)計學(xué)意義（P>0.05）;研究組患者治療后1～3 d的嘔血次數(shù)為（1.30±0.80）次，黑便次數(shù)為（1.40±0.56）次，對照組患者治療后1～3 d的嘔血次數(shù)為（1.85±0.95）次，黑便次數(shù)為（1.75±0.65）次，兩組患者治療后1～3 d的嘔血次數(shù)、黑便次數(shù)均少于治療前，差異有統(tǒng)計學(xué)意義（P<0.05），研究組患者治療后1～3 d的嘔血次數(shù)、黑便次數(shù)均少于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）;兩組患者治療后4～7 d均未發(fā)生嘔血，兩組患者治療后4～7 d的嘔血次數(shù)比較，差異無統(tǒng)計學(xué)意義（P>0.05）;研究組患者治療后4～7 d的黑便次數(shù)為（0.21±0.10）次，對照組患者治療后4～7 d的黑便次數(shù)為（0.32±0.12）次，研究組患者治療后4～7 d的黑便次數(shù)少于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。研究組患者的并發(fā)癥總發(fā)生率為4.00%，對照組患者的并發(fā)癥總發(fā)生率為18.00%，研究組患者的并發(fā)癥總發(fā)生率低于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 消化性潰瘍合并上消化道出血應(yīng)用泮托拉唑輔助治療的臨床效果確切。

[關(guān)鍵詞]泮托拉唑;消化性潰瘍;上消化道出血;臨床效果

[中圖分類號] R632.1? ? ? ? ? [文獻標識碼] A? ? ? ? ? [文章編號] 1674-4721（2019）8（c）-0060-04

[Abstract] Objective To explore the clinical effect of Pantoprazole in the adjuvant treatment of peptic ulcer complicated with upper gastrointestinal hemorrhage. Methods One hundred patients with peptic ulcer complicated with upper gastrointestinal hemorrhage treated from January to December 2017 were enrolled as subjects and divided into the control group （50 cases） and the study group （50 cases） according to the random number table method. Patients in the control group were given Omeprazole， and those in the study group were additionally given Pantoprazole. The clinical effects， times of haematemesis and melena before treatment and at different time after treatment， and the incidence of complications were compared between the two groups. Results The overall effective rate in the study group was 96.00%， significantly higher than the 78.00% in the control group （P<0.05）. The times of haematemesis was （2.98±1.21） in the study group before treatment， and that of melena was （2.21±1.02）， which was （3.02±1.20） and （2.20±1.03） in the control group， showing no significant difference between two groups （P>0.05）. The times of haematemesis was （1.30±0.80） in the study group at 1-3 d after treatment and that of melena was （1.40±0.56）， which was （1.85±0.95） and （1.75±0.65） in the control group at 1-3 d after treatment， the times of haematemesis and melena were significantly fewer than those before treatment in both groups （P<0.05）， and those in the study group were significantly fewer than those in the control group （P<0.05）. The times of haematemesis was 0 in the two groups at 4-7 d after treatment， showing no significant difference between two groups （P>0.05）. The times of melena was （0.21±0.10） in the study group at 4-7 d after treatment， and that of the control group was （0.32±0.12）， which was significantly fewer in the study group （P<0.05）. The total incidence of complications was 4.00% in the study group and 18.00% in the control group， the total incidence of complications in the study group was lower than that in the control group， and the difference was statistically significant （P<0.05）. Conclusion The clinical effect of Pantoprazole adjuvant therapy for peptic ulcer combined with upper gastrointestinal bleeding is definite.