劉海英　羅玉

【摘要】 目的：探究左甲狀腺素鈉治療老年甲狀腺功能減退綜合征的有效性。方法：選取2016年12月-2018年12月于筆者所在醫(yī)院接受治療的72例老年甲狀腺功能減退綜合征患者，分為觀察組和對照組，每組36例。對照組給予甲狀腺片治療，觀察組給予左甲狀腺素鈉治療。對比兩組治療總有效率及甲狀腺功能各項指標水平。結(jié)果：觀察組治療后FT4明顯高于對照組，TSH、FT3均明顯低于對照組（P<0.05）。治療后，兩組FT4與FT3均明顯高于治療前，TSH明顯低于治療前（P<0.05）。對照組總有效率為83.33%，顯著低于觀察組的97.22%（P<0.05）。結(jié)論：針對老年甲狀腺功能減退綜合征患者采用左甲狀腺素鈉治療，可有效改善甲狀腺功能，提高治療有效率，具有廣泛的應(yīng)用價值。

【關(guān)鍵詞】 老年甲狀腺功能減退; 左甲狀腺素鈉; 有效性

doi：10.14033/j.cnki.cfmr.2019.20.049 文獻標識碼 B 文章編號 1674-6805（2019）20-0-02

Efficacy of Levothyroxine Sodium in the Treatment of Senile Hypothyroidism Syndrome/LIU Haiying，LUO Yu.//Chinese and Foreign Medical Research，2019，17（20）：-112

【Abstract】 Objective：To investigate the effectiveness of Levothyroxine Sodium in the treatment of senile hypothyroidism syndrome.Method：72 elderly patients with hypothyroidism were selected from December 2016 to December 2018.The patients were divided into the observation group and the control group，and 36 cases in each group.The control group was treated with Thyroid Tablet and the observation group was treated with Levothyroxine Sodium.The total effective rate and the level of thyroid function indexes of the two groups were compared.Result：After treatment，the level of FT4 in the observation group was significantly higher than that of the control group，and TSH and FT3 were significantly lower than those of the control group（P<0.05）.After treatment，F(xiàn)T4 and FT3 levels of the two groups was significantly higher than before treatment，and TSH was significantly lower than before treatment（P<0.05）.The total effective rate of the control group was 83.33%，which was significantly lower than 97.22% of the observation group（P<0.05）.Conclusion：The use of Levothyroxine Sodium in the treatment of elderly patients with hypothyroidism syndrome can improve thyroid function effectively，improve the effective rate of treatment，and have wide application value.

【Key words】 Senile hypothyroidism; Levothyroxine Sodium; Effectiveness

First-authors address：The Fifth Peoples Hospital of Sichuan Province，Mianyang 610031，China

甲狀腺功能減退綜合征，為臨床上常見的一種慢性疾病，記憶力衰退、嗜睡、疲乏、認知損傷等為常見臨床癥狀，多發(fā)生于老年人群，對患者的生活質(zhì)量產(chǎn)生嚴重影響[1]。引起老年人甲狀腺功能減退綜合征主要原因為甲狀腺激素合成、分泌不足，生物效應(yīng)下降[2]。此次研究針對老年甲狀腺功能減退綜合征患者進行左甲狀腺素鈉治療，分析藥物的有效性，結(jié)果如下。

1 資料與方法

1.1 一般資料

選取2016年12月-2018年12月于筆者所在醫(yī)院接受治療的72例老年甲狀腺功能減退綜合征患者。納入標準：來院治療前未服用降脂藥物;無糖尿病、腎病、惡性腫瘤等疾病史。將72例患者分為觀察組和對照組，每組36例。觀察組男26例，女10例;年齡60～80歲。對照組男24例，女12例;年齡62～82歲。兩組一般資料對比，差異均無統(tǒng)計學(xué)意義（P>0.05），有可比性。研究經(jīng)醫(yī)院倫理委員會批準，患者均自愿參與且簽署知情同意書。