于閱盡+黃衛(wèi)+張慧+黃秋燕+黃少鷹

【摘要】目的： 探討中醫(yī)定向透藥療法治療主要表現(xiàn)為上氣道咳嗽綜合征（UACS）的慢性咳嗽的臨床效果。方法： 將138例來(lái)我院耳鼻喉科就診的UACS慢性咳嗽患者按隨機(jī)數(shù)字表法分為治療組和對(duì)照組各69例。2組均口服氯雷他定1周，鼻腔吸人糖皮質(zhì)激素1月。治療組在此基礎(chǔ)上加用中醫(yī)定向透藥治療儀輔助治療，隔天1次，連續(xù)5次，對(duì)照組不予藥物導(dǎo)入治療。結(jié)果： 兩組治療前后，咳嗽程度、鼻部癥狀和體征、咽部癥狀方面均明顯改善；組間比較，除鼻部癥狀外，咳嗽和咽部癥狀治療組評(píng)分明顯低于單純藥物治療對(duì)照組，統(tǒng)計(jì)學(xué)分析呈顯著性差異（P <0.05）。臨床療效治療組總有效率（89.9%）明顯高于單純藥物治療對(duì)照組（76.8%），統(tǒng)計(jì)學(xué)分析呈顯著性差異（P =0.033）。結(jié)論：在西醫(yī)常規(guī)治療基礎(chǔ)上加用中醫(yī)定向透藥療法治療慢性咳嗽能顯著改善患者癥狀，提高其生活質(zhì)量，值得推廣。

【關(guān)鍵詞】 中醫(yī)定向透藥療法；慢性咳嗽；上氣道咳嗽綜合征

[Abstract] Objective： To evaluate the clinical efficacy of Chinese medicine targeted transdermal therapy for treating upper airway cough syndrome （UACS）， a main manifestation of chronic cough. Methods： A total of 138 patients who were diagnosed with UACS at the Department of Ear Nose and Throat （ENT） were randomly divided into the treatment group and the control group （69 patients per group）. Both groups received oral loratadine for 1 week， and nasal inhalation of glucocorticoid for 1 month. In addition to these， the treatment group also received Chinese medicine targeted transdermal therapy as an adjuvant therapy once every 2 days， for a total of 5 times. The control group was not treated with any additional drugs. Results：The severity of coughing， nasal symptoms， pharyngeal symptoms and physical signs were significant improved in both groups following treatment. Besides nasal symptoms， coughing and pharyngeal symptoms were significantly lower in the treatment group compared to the drug therapy control group （P <0.05）. In addition， the total clinical efficacy was significantly higher in the treatment group （89.9%） than the drug therapy control group （76.8%） （P=0.033）. Conclusions： The addition of Chinese medicine targeted transdermal therapy on the basis of conventional treatment can significantly improve the symptoms of chronic coughing and enhance patients quality of life， and therefore should be widely promoted as an adjuvant treatment for chronic coughing.

[Key words] Chinese medicine targeted transdermal therapy； chronic coughing； upper airway cough syndrome

【中圖分類(lèi)號(hào)】R445.62

【文獻(xiàn)標(biāo)識(shí)碼】A

【文章編號(hào)】2095-6851（2017）08-074-01

慢性咳嗽也可稱(chēng)為慢性干咳。臨床通常將以咳嗽為唯一癥狀或主要癥狀，時(shí)間超過(guò)8周， 胸部X線(xiàn)檢查正常者稱(chēng)為不明原因慢性咳嗽， 簡(jiǎn)稱(chēng)慢性咳嗽。上氣道咳嗽綜合征（upper airway cough syndrome，UACS）是引起慢性咳嗽的常見(jiàn)癥因之一^[1]，2006美國(guó)ACCP指南編撰委員會(huì)將由上呼吸道疾病如普通感冒等通過(guò)鼻分泌物后流和/或炎癥刺激引起的咳嗽統(tǒng)稱(chēng)為UACS^[2]。由于本病療程偏長(zhǎng)、癥狀容易反復(fù)，影響患者的生活質(zhì)量，故引起臨床醫(yī)生關(guān)注。近年來(lái)，中醫(yī)藥治療慢性咳嗽取得了一定的進(jìn)展，可能有助于解決慢性咳嗽治療中的一些困境。我科自2014年開(kāi)展了中醫(yī)定向透藥療法配合藥物治療慢性咳嗽取得一定療效，現(xiàn)報(bào)道如下。

1 資料與方法

1.1 病例選擇及分組：收集的病例為我院耳鼻喉科門(mén)診就診的符合上氣道咳嗽綜合征診斷標(biāo)準(zhǔn)的慢性咳嗽患者，共138例。按1：1比例隨機(jī)分為治療組和對(duì)照組。排除有急性細(xì)菌性感染、胃食管反流、咳嗽變異性哮喘、支氣管哮喘、異物吸入及先天性氣道疾病等心肺部疾病、合并鼻息肉、嚴(yán)重鼻中隔偏曲、裝有人工支架、人工瓣膜與人工起搏器的患者。endprint