李民

[摘要]目的 探究維生素C聯(lián)合鹽酸雷尼替丁膠囊治療復發(fā)性口腔潰瘍的臨床應(yīng)用效果及對患者免疫功能的影響。方法 選取2016年4月～2017年4月我院收治的140例復發(fā)性口想潰瘍患者作為研究對象，將其按照隨機數(shù)字表法分為對照組（70例）和觀察組（70例）。對照組患者采用常規(guī)的維生素C進行治療，觀察組患者采用維生素C聯(lián)合鹽酸雷尼替丁膠囊治療。對比分析兩組患者的治療總有效率以及T淋巴細胞陽性（CD3+）、輔助性T淋巴細胞陽性（CD4+）、抑制/殺傷性T淋巴細胞陽性（CD8+）、CD4+/CD8+各項指標的變化情況。結(jié)果 觀察組患者的治療總有效率明顯高于對照組，差異有統(tǒng)計學意義（P<0.05）。治療后，觀察組患者的CD3+水平明顯高于對照組，差異有統(tǒng)計學意義（P<0.05）。觀察組患者的CD4+與對照組比較，差異無統(tǒng)計學意義（P>0.05）。觀察組患者的CD8+水平明顯低于對照組，差異有統(tǒng)計學意義（P<0.05）。觀察組患者的CD4+/CD8+水平明顯高于對照組，差異有統(tǒng)計學意義（P<0.05）。結(jié)論 維生素C聯(lián)合鹽酸雷尼替丁膠囊治療復發(fā)性口腔潰瘍的臨床效果顯著，有助于潰瘍愈合，提高患者的免疫功能，值得在臨床上推廣應(yīng)用。

[關(guān)鍵詞]維生素C；鹽酸雷尼替丁膠囊；復發(fā)性口腔潰瘍

[中圖分類號] R781.5 [文獻標識碼] A [文章編號] 1674-4721（2018）9（c）-0114-03

Effect of application of combination of Vitamin C and Ranitidine Hydrochlorlde Capsules in the treatment of recurrent oral ulcer

LI Min

Department of Stomatology， Oral Clinic， Liaoning Province， Yingkou 115000， China

[Abstract] Objective To explore the clinical effect of application of combination of Vitamin C and Ranitidine Hydrochlorlde Capsules in the treatment of recurrent oral ulcer （ROU） and its influence on the patients′ immune function. Methods Altogether 140 cases with ROU who were treated in our hospital from April 2016 to April 2017 were selected as the subjects of this research， and divided into the control group （70 cases） and the observation group （70 cases） according to the random number method. Patients in the control group were treated with Vitamin C， while the patients in the observation group were treated with the combination of Vitamin C and Ranitidine Hydrochlorlde Capsules. The total effective rate and the changes of various indexes of the two groups， such as T lymphocyte positive （CD3+）， auxiliary T lymphocyte positive （CD4+）， suppressor/cytotoxic T lymphocyte positive （CD8+） and CD4+/CD8+ were compared. Results The total effective rate of the observation group was significantly higher than that of the control group， with statistically significant difference （P<0.05）. The post-treatment CD3+ level of the observation group was significantly higher than that of the control group， with statistically significant difference （P<0.05）. There was nostatistically significant difference in CD4+ between the observation group and the control group （P>0.05）. The CD8+ level of the observation group was significantly lower than that of the control group， with statistically significant difference （P<0.05）. The CD4+/CD8+ level of the observation group was significantly higher than that of the control group， with statistically significant difference （P<0.05）. Conclusion Application of combination of Vitamin C and Ranitidine Hydrochlorlde Capsules achieves significant effect in the treatment of ROU， conduciveness to ulcer healing and improvement of patients′ immune function， which is worth popularizing in clinical practice.