0.05);研究組男、女BDNF表達(dá)水平為(29.86±4."/>
邱雪蘭 林彩鳳 汪珍艷
[摘要]目的 探討綜合護(hù)理干預(yù)對(duì)不同性別的抑郁癥患者腦源性神經(jīng)營(yíng)養(yǎng)因子(BDNF)和皮質(zhì)醇(Cor)表達(dá)影響。方法 選取2018年8月~2019年8月我院收治的60例抑郁癥患者為研究對(duì)象,按照隨機(jī)數(shù)字表法分為對(duì)照組和研究組,每組各30例。對(duì)照組實(shí)施常規(guī)護(hù)理干預(yù),研究組實(shí)施綜合護(hù)理干預(yù),為期8周。比較兩組不同性別干預(yù)前BDNF和Cor的表達(dá)水平。結(jié)果 兩組干預(yù)前BDNF、Cor表達(dá)水平比較,差異無(wú)統(tǒng)計(jì)學(xué)意義(P>0.05);研究組男、女BDNF表達(dá)水平為(29.86±4.02)、(27.78±3.35)pg/ml,高于對(duì)照組的(26.14±3.71)、(24.36±3.29)pg/ml,兩組干預(yù)后男、女患者BDNF表達(dá)水平高于干預(yù)前,差異均有統(tǒng)計(jì)學(xué)意義(P<0.05);研究組男、女Cor表達(dá)水平為(84.03±13.81)、(86.64±14.07)pg/ml,低于對(duì)照組的(97.56±14.52)、(100.12±15.92)pg/ml,兩組干預(yù)后男、女患者Cor表達(dá)水平低于干預(yù)前,差異均有統(tǒng)計(jì)學(xué)意義(P<0.05)。結(jié)論 不同性別抑郁癥患者實(shí)施綜合護(hù)理干預(yù)效果顯著,能改善患者BDNF和Cor的表達(dá)水平。
[關(guān)鍵詞]抑郁癥;性別;綜合護(hù)理干預(yù);腦源性神經(jīng)營(yíng)養(yǎng)因子;皮質(zhì)醇
[中圖分類號(hào)] R473.74? ? ? ? ? [文獻(xiàn)標(biāo)識(shí)碼] A? ? ? ? ? [文章編號(hào)] 1674-4721(2020)8(b)-0202-04
[Abstract] Objective To investigate the effects of comprehensive nursing intervention on the expression of brain-derived neurotrophic factor (BDNF) and cortisol (Cor) in patients with depression of different genders. Methods A total of 60 patients with depression who were admitted to our hospital from August 2018 to August 2019 were selected as research subjects. They were divided into control group and study group according to the random number table method, 30 cases in each group. The control group underwent routine nursing intervention, and the study group implemented comprehensive nursing intervention for a period of 8 weeks. The expression levels of BDNF and Cor were compared between the two groups of patients with different genders before and after intervention. Results The expression of BDNF and Cor in the study group was not significantly different from those in the control group before intervention (P>0.05). The expression level of BDNF in male and female in the study group were (29.86±4.02) and (27.78±3.35) pg/ml, higher than those of the control group of (26.14±3.71) and (24.36±3.29) pg/ml, after intervention, the expression levels of BDNF in male and female patients were higher than those before intervention, with significant differences (P<0.05). The Cor expression levels of the study group in males and females were (84.03±13.81) and (86.64±14.07) pg/ml, which were lower than those of the control group of (97.56±14.52) and (100.12±15.92) pg/ml, the expression levels of Cor in male and female patients after intervention were lower than those before intervention, with significant differences (P<0.05). Conclusion The effect of comprehensive nursing intervention was significant in patients with depression of different genders, which could improve the expression level of BDNF and Cor.
綜上所述,綜合護(hù)理干預(yù)在不同性別抑郁癥患者均有較高的應(yīng)用價(jià)值,能改善患者BDNF和Cor的表達(dá)水平,有利于緩解抑郁癥狀。
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(收稿日期:2019-11-13)