黃琪述　梁景強(qiáng)　陳錦華

【摘要】 目的 探討中性粒細(xì)胞明膠酶相關(guān)脂質(zhì)運載蛋白（NGAL）在肺癌性胸腔積液的變化情況， 分析其對惡性胸腔積液的診斷價值。方法 64例肺癌伴胸腔積液患者作為肺癌組， 60例良性胸腔積液患者作為良性組。比較兩組胸腔積液中NGAL水平及肺癌組不同病理特征肺癌患者胸腔積液NGAL水平的差異。結(jié)果 肺癌組患者胸腔積液NGAL水平（61.84±10.59）ng/ml高于良性組患者的（48.32±

8.11）ng/ml， 差異有統(tǒng)計學(xué)意義（P<0.05）。胸腔積液NGAL水平與肺癌病理類型無關(guān)（P>0.05）；腫瘤直徑越大， 淋巴結(jié)轉(zhuǎn)移越多， 分化程度越低的患者， 其胸腔積液中NGAL水平越高， 差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論 肺癌性胸腔積液中NGAL水平顯著高于良性胸腔積液， 并且其水平與腫瘤大小、分化程度及淋巴結(jié)轉(zhuǎn)移情況相關(guān)， 可作為惡性胸腔積液的判斷指標(biāo)， 并用于評價肺癌惡性程度。

【關(guān)鍵詞】 中性粒細(xì)胞明膠酶相關(guān)脂質(zhì)運載蛋白；肺癌；胸腔積液

DOI：10.14163/j.cnki.11-5547/r.2017.21.008

Changes of neutrophil gelatinase-associated lipocalin in pleural effusion of lung cancer HUANG Qi-shu， LIANG Jing-qiang， CHEN Jin-hua. Dongguan Wangniudun Hospital， Dongguan 523200， China

【Abstract】 Objective To investigate the changes of neutrophil gelatinase-associated lipocalin （NGAL） in pleural effusion of lung cancer， and analyze its diagnostic value for malignant pleural effusion. Methods There were 64 patients with lung benign and pleural effusion as lung cancer group， and 60 patients with with benign pleural effusion as benign group. Comparison were made on NGAL level in pleural effusion between two groups and difference of NGAL levels in pleural effusion of lung cancer patients with different pathological features. Results The lung cancer group had higher NGAL level in pleural effusion as （61.84±10.59） ng/ml than （48.32±8.11） ng/ml in the benign group， and the difference had statistical significance （P<0.05）. NGAL level in pleural effusion was not correlated with pathological types of lung cancer （P>0.05）. Patients with larger diameter of the tumor， more lymph node metastasis and lower degree of differentiation had higher the level of NGAL in the pleural effusion， and the difference had statistical significance （P<0.05）. Conclusion The level of NGAL in pleural effusion of lung cancer was significantly higher than that of benign pleural effusion， and its level was correlated with tumor size， differentiation degree and lymph node metastasis. So it could be used as an indicator evaluating the degree of malignancy of lung cancer.

【Key words】 Neutrophil gelatinase-associated lipocalin； Lung cancer； Pleural effusion

據(jù)全球癌癥統(tǒng)計數(shù)據(jù)顯示， 肺癌的發(fā)病率及死亡率在男性所患所有惡性腫瘤中均位第一， 在女性當(dāng)中發(fā)病率位居第三， 死亡率僅次于乳腺癌位居第二位[1]， 在我國， 不論男女， 肺癌的死亡率已成為各類惡性腫瘤之首， 嚴(yán)重威脅著人類的生命健康[2]。胸腔積液是晚期肺癌的一個常見的臨床表現(xiàn)， 其良惡性的判斷與肺癌治療、預(yù)后密切相關(guān)。中性粒細(xì)胞明膠酶相關(guān)脂質(zhì)運載蛋白（neutrophil gelatinase-associated lipocalin， NGAL）是載脂蛋白家族成員， 與腫瘤的發(fā)生、發(fā)展密切相關(guān)[3]。本研究旨在探索NGAL在肺癌性胸腔積液的變化情況， 以分析其對惡性胸腔積液的診斷價值及與肺癌生物學(xué)行為間的關(guān)系， 現(xiàn)報告如下。