亚洲免费av电影一区二区三区,日韩爱爱视频,51精品视频一区二区三区,91视频爱爱,日韩欧美在线播放视频,中文字幕少妇AV,亚洲电影中文字幕,久久久久亚洲av成人网址,久久综合视频网站,国产在线不卡免费播放

        ?

        TScan-II: A genome-scale platform for the de novo identification of CD4+ T cell epitopes

        2023-04-23 03:21:52MohammadDezfulianetal
        四川生理科學雜志 2023年11期

        Mohammad H Dezfulian, et al.

        CD4+T cells play fundamental roles in orchestrating immune responses and tissue homeostasis. However, our inability to associate peptide human leukocyte antigen class-II (HLA-II) complexes with their cognate T cell receptors (TCRs) in an unbiased manner has hampered our understanding of CD4+T cell function and role in pathologies. Here, we introduce TScan-II, a highly sensitive genome-scale CD4+antigen discovery platform. This platform seamlessly integrates the endogenous HLA-II antigenprocessing machinery in synthetic antigen-presenting cells and TCR signaling in T cells, enabling the simultaneous screening of multiple HLAs and TCRs. Leveraging genome-scale human, virome, and epitope mutagenesis libraries, TScan-II facilitates de novo antigen discovery and deep exploration of TCR specificity. We demonstrate TScan-II's potential for basic and translational research by identifying a non-canonical antigen for a cancer-reactive CD4+T cell clone. Additionally, we identified two antigens for clonally expanded CD4+T cells in Sj?gren's disease, which bind distinct HLAs and are expressed in HLA-II-positive ductal cells within affected salivary glands.

        挑战亚洲美女视频网站| 婷婷五月综合丁香在线| 国产精品露脸视频观看| 国产成人丝袜在线无码| 日本女优久久精品久久| 欧美激情一区二区三区成人 | 揄拍成人国产精品视频| 色婷婷综合一区二区精品久久| 中文字幕一区久久精品| 国产99在线 | 亚洲| 可以免费观看的毛片| 久久av一区二区三区下| 97超碰精品成人国产| 九九热线有精品视频86| 中文字幕第1页中文字幕在| 久久精品国产亚洲av热九 | 日美韩精品一区二区三区| 美女视频在线观看亚洲色图| 在线欧美中文字幕农村电影| 欧美在线成人午夜网站| 在线免费午夜视频一区二区| 日本精品一区二区三区二人码| 中年熟妇的大黑p| 亚洲AV无码未成人网站久久精品 | 亚洲精品无码av人在线观看| 厨房玩丰满人妻hd完整版视频| 40分钟永久免费又黄又粗| 国产白浆一区二区在线| 亚洲国产欧美日韩欧美特级 | 无码国产精品一区二区高潮| 亚洲成a人片在线播放观看国产| 国产丝袜长腿在线看片网站| 99麻豆久久久国产精品免费| 久久97精品久久久久久久不卡| 免费高清视频在线观看视频| 日韩一区av二区三区| 污污内射在线观看一区二区少妇| 浪荡少妇一区二区三区| 日本女优久久精品久久| 一本色道久久综合无码人妻| 国产尻逼视频|