周燕莉 王焰

【摘要】 目的 探討類風(fēng)濕關(guān)節(jié)炎應(yīng)用關(guān)節(jié)腔內(nèi)注射治療的臨床效果。方法 100例類風(fēng)濕關(guān)節(jié)炎患者， 隨機(jī)分為關(guān)節(jié)腔內(nèi)注射治療組和常規(guī)治療組， 每組50例。常規(guī)治療組給予甲氨蝶呤治療， 關(guān)節(jié)腔內(nèi)注射治療組在常規(guī)治療組基礎(chǔ)上給予關(guān)節(jié)腔內(nèi)注射玻璃酸鈉治療。觀察比較兩組治療前后關(guān)節(jié)視覺模擬評(píng)分、晨僵維持時(shí)間、腫脹程度評(píng)分、C反應(yīng)蛋白、血沉、疼痛癥狀消失時(shí)間、疼痛癥狀緩解時(shí)間以及不良反應(yīng)發(fā)生情況。結(jié)果 治療后， 關(guān)節(jié)腔內(nèi)注射治療組關(guān)節(jié)視覺模擬評(píng)分（1.24±0.15）分、晨僵維持時(shí)間（1.24±0.12）h、腫脹程度（5.53±1.01）分、C反應(yīng)蛋白（10.19±2.36）μg/L、血沉（34.56±3.26）mm/h均低于常規(guī)治療組的（3.24±1.34）分、（1.78±0.61）h、（6.56±1.42）分、（14.11±4.12）μg/L、（45.72±12.11）mm/h， 差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）;關(guān)節(jié)腔內(nèi)注射治療組疼痛癥狀消失時(shí)間、疼痛癥狀緩解時(shí)間分別為（42.12±3.57）、（12.12±3.21）d， 明顯短于常規(guī)治療組的（57.57±3.89）、（18.57±3.24）d， 差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。兩組不良反應(yīng)發(fā)生率比較， 差異無(wú)統(tǒng)計(jì)學(xué)意義（P>0.05）。結(jié)論 類風(fēng)濕關(guān)節(jié)炎患者實(shí)施關(guān)節(jié)腔內(nèi)注射玻璃酸鈉治療可獲得較好效果。

【關(guān)鍵詞】 類風(fēng)濕關(guān)節(jié)炎;關(guān)節(jié)腔內(nèi)注射;玻璃酸鈉

DOI：10.14163/j.cnki.11-5547/r.2019.29.037

【Abstract】 Objective? ?To discuss the clinical effect of intra-articular injection of sodium hyaluronate for the treatment of rheumatoid arthritis. Methods? ?A total of 100 rheumatoid arthritis patients were randomly divided into intra-articular injection group and conventional treatment group， with 50 cases in each group. The conventional treatment group received methotrexate for treatment， and the intra-articular injection group received intra-articular injection of sodium hyaluronate on the basis of the conventional treatment group. Observation and comparison were made on visual analogue score of joint， duration of morning stiffness， degree of swelling， C-reactive protein， erythrocyte sedimentation rate before and after treatment， disappearance time of pain symptoms， remission time of pain symptoms and occurrence of adverse reactions between the two groups. Results? ?After treatment， the visual analogue score of joint （1.24±0.15） points， duration of morning stiffness （1.24±0.12） h， duration of morning stiffness （5.53±1.01） points， C-reactive protein （10.19±2.36） μg/L and erythrocyte sedimentation rate （34.56±3.26） mm/h in the intra-articular injection group were lower than （3.24±1.34） points， （1.78±0.61） h， （6.56±1.42） points， （14.11±4.12） μg/L and （45.72±12.11） mm/h in the conventional treatment group. Their difference was statistically significant （P<0.05）. The disappearance time of pain symptoms and remission time of pain symptoms respectively as （42.12±3.57） and （12.12±3.21） d in the intra-articular injection group， and that were obviously shorter than （57.57±3.89） and （18.57±3.24） d in conventional treatment group. Their difference was statistically significant （P<0.05）. There was no statistically significant difference in incidence of adverse reactions between the two groups （P>0.05）. Conclusion? ?Intra-articular injection of sodium hyaluronate in rheumatoid arthritis patients can achieve better results.