葉章海

[摘要]目的 觀察不同劑量鹽酸氨溴索注射液治療老年腦卒中相關(guān)性肺炎（Stroke-related pneumonia，SPA）的臨床療效。方法 選取2016年1月～2017年6月我院收治的90例確診為SAP患者為研究對象，隨機分為低劑量鹽酸氨溴索組（低劑量組30例）、高劑量鹽酸氨溴索組（高劑量組30例）和對照組（30例），對照組僅給予常規(guī)抗生素治療，鹽酸氨溴索組輔以不同劑量的鹽酸氨溴索治療，比較三組患者的抗生素使用時間、退熱時間、住院時間、動脈血氧分壓、C反應(yīng)蛋白及細菌清除率，分析三組臨床療效。結(jié)果 高劑量組和低劑量組的臨床治療總有效率均高于對照組（P<0.05），且高劑量組高于低劑量組，差異有統(tǒng)計學(xué)意義（P<0.05）；高劑量組和低劑量組的抗生素使用時間、退熱時間、住院時間明顯短于對照組（P<0.05），且高劑量組短于低劑量組，差異有統(tǒng)計學(xué)意義（P<0.05）；高劑量組和低劑量組的動脈血氧分壓高于對照組（P<0.05），且高劑量組高于低劑量組，差異有統(tǒng)計學(xué)意義（P<0.05）；三組治療后C反應(yīng)蛋白水平無明顯差異，差異無統(tǒng)計學(xué)意義（P>0.05）；高劑量組細菌清除率為90.27%，低劑量組細菌清除率為68.51%，對照組細菌清除率為57.80%，三組細菌清除率比較差異有統(tǒng)計學(xué)意義（P<0.05）；三組臨床不良反應(yīng)發(fā)生率比較差異無統(tǒng)計學(xué)意義（P>0.05）。結(jié)論 高劑量鹽酸氨溴索治療SPA的療效顯著，可提高細菌清除率，且臨床較為安全，值得推廣應(yīng)用。

[關(guān)鍵詞]鹽酸氨溴索；腦卒中相關(guān)性肺炎；不同劑量；療效

[中圖分類號] R743.3 [文獻標識碼] A [文章編號] 1674-4721（2017）11（a）-0058-04

Comparison of different doses of Ambroxol Hydrochloride Injection in the treatment of stroke-related pneumonia in the elderly

YE Zhang-hai

Department of Neurology，the Second People′s Hospital of Zhaoqing City，Guangdong Province，Zhaoqing 526060，China

[Abstract]Objective To investigate the clinical efficacy of different doses of Ambroxol Hydrochloride in the treatment of stroke-related pneumonia in the elderly.Methods A total of 90 patients with acute stroke were diagnosed as SAP in our hospital from January 2016 to June 2017.They were randomly divided into low-dose Ambroxol Hydrochloride group （low-dose group 30 cases），high-dose Ammonia Bovine group（high-dose group 30 cases） and control group（30 cases）.The control group received only routine antibiotic therapy.Ambroxol Hydrochloride group was supplemented with different doses of Ambroxol Hydrochloride，and the antibiotic use time，fever time，hospitalization time，arterial oxygen partial pressure，C-reactive protein and bacterial clearance rate，analyed of three groups of clinical efficacy.Results The total effective rate of high-dose group and low-dose group was higher than that of control group （P<0.05），and high-dose group was higher than low-dose group，the difference was statistically significant（P<0.05）.The antibiotic use time，fever time and hospitalization time of the high dose group and low dose group were significantly shorter than those of the control group（P<0.05），and the high dose group was shorter than that of low dose group，the difference was statistically significant（P<0.05）.The high dose group was higher than that of low dose group（P<0.05），and the high dose of group and low dose group was higher than that of control group， the difference was statistically significant（P<0.05）.There was no significant difference in C-reactive protein between the three groups（P>0.05）.The bacterial clearance ratein the high-dose group was 90.27% and the low-dose group was 68.51%.The bacterial clearance rate in the control group was 57.80%，and the difference was statistically significant （P<0.05）.There was no significant difference in the incidence of clinical adverse reactions between the three groups（P>0.05）.Conclusions High-dose Ambroxol Hydrochloride in the treatment of stroke-related pneumonia in elderly patients with significant effect，can improve bacterial clearance，and clinical safer， worthy of promotion and application.endprint