亚洲免费av电影一区二区三区,日韩爱爱视频,51精品视频一区二区三区,91视频爱爱,日韩欧美在线播放视频,中文字幕少妇AV,亚洲电影中文字幕,久久久久亚洲av成人网址,久久综合视频网站,国产在线不卡免费播放

        ?

        Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

        2021-01-07 23:21:09EdwardWalshetal
        四川生理科學(xué)雜志 2021年1期

        Edward E Walsh, et al.

        Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections and the resulting disease,coronavirus disease 2019 (Covid-19), have spread to millions of persons worldwide.Multiple vaccine candidates are under development, but no vaccine is currently available.Interim safety and immunogenicity data about the vaccine candidate BNT162b1 in younger adults have been reported previously from trials in Germany and the United States.

        Methods: In an ongoing, placebo-controlled, observer-blinded, dose-escalation, phase 1 trial conducted in the United States,we randomly assigned healthy adults 18 to 55 years of age and those 65 to 85 years of age to receive either placebo or one of two lipid nanoparticle-formulated, nucleoside-modified RNA vaccine candidates: BNT162b1, which encodes a secreted trimerized SARS-CoV-2 receptor-binding domain; or BNT162b2, which encodes a membrane-anchored SARS-CoV-2 full-length spike, stabilized in the prefusion conformation.The primary outcome was safety (e.g., local and systemic reactions and adverse events); immunogenicity was a secondary outcome.Trial groups were defined according to vaccine candidate, age of the participants, and vaccine dose level (10 μg, 20 μg, 30 μg, and 100 μg).In all groups but one, participants received two doses, with a 21-day interval between doses; in one group (100 μg of BNT162b1), participants received one dose.

        Results: A total of 195 participants underwent randomization.In each of 13 groups of 15 participants, 12 participants received vaccine and 3 received placebo.BNT162b2 was associated with a lower incidence and severity of systemic reactions than BNT162b1, particularly in older adults.In both younger and older adults, the two vaccine candidates elicited similar dose-dependent SARS-CoV-2-neutralizing geometric mean titers, which were similar to or higher than the geometric mean titer of a panel of SARS-CoV-2 convalescent serum samples.

        Conclusions: The safety and immunogenicity data from this U.S.phase 1 trial of two vaccine candidates in younger and older adults, added to earlier interim safety and immunogenicity data regarding BNT162b1 in younger adults from trials in Germany and the United States, support the selection of BNT162b2 for advancement to a pivotal phase 2-3 safety and efficacy evaluation.(Funded by BioNTech and Pfizer; ClinicalTrials.gov number, NCT04368728.).

        亚洲人成网址在线播放| 91热视频在线观看| 亚洲中文字幕诱惑第一页| 国产福利一区二区三区在线观看| 精品精品久久宅男的天堂 | 国产三区在线成人av| 999久久久精品国产消防器材| 蜜桃视频中文在线观看| 美女射精视频在线观看| 欧洲美女黑人粗性暴交视频| 亚洲热线99精品视频| 国产精品高潮呻吟av久久4虎| 99精品成人片免费毛片无码| 亚洲性爱区免费视频一区| 全部亚洲国产一区二区| 四虎影在永久在线观看| 人妻丰满熟妇av无码片| 欧美色图50p| 国语对白三级在线观看| 国产精品日韩av一区二区| 无码人妻精品一区二区三区东京热 | 免费视频无打码一区二区三区| 国产成人a人亚洲精品无码| 乱码一二三入区口| 亚洲V无码一区二区三区四区观看 久久精品国产亚洲综合色 | 九九视频在线观看视频6| 国产精品久久久久久久久免费观看| 少妇一级aa一区二区三区片| 久久精品国产亚洲av四区| 亚洲成av人片在线观看| 国产精品沙发午睡系列990531| 日韩中文字幕一区二区高清| 日本黄网色三级三级三级| 日韩综合无码一区二区| 成人看片黄a免费看那个网址| 免费中文熟妇在线影片| 亚洲av色香蕉一区二区三区av| 亚洲精品久久久久久久蜜桃| 亚洲精品综合一区二区| 久久精品—区二区三区无码伊人色 | 东风日产系列全部车型|