梅英 黃金鵬
[摘要] 目的 探討小柴胡湯加減方治療頸淋巴結(jié)結(jié)核的臨床療效。 方法 于2016年1月~2017年12月選擇我院治療的頸淋巴結(jié)結(jié)核60例患者進(jìn)行研究,隨機(jī)分為聯(lián)合組與對(duì)照組各30例。對(duì)照組給予抗結(jié)核治療,聯(lián)合組在此基礎(chǔ)上給予小柴胡湯加減方治療。比較兩組臨床療效及治療前后血沉、淋巴結(jié)最大橫徑。 結(jié)果 兩組治療后淋巴結(jié)最大橫徑均小于治療前,差異有統(tǒng)計(jì)學(xué)意義(P<0.05);治療后,聯(lián)合組淋巴結(jié)最大橫徑顯著小于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。兩組治療后血沉水平均低于治療前,差異有統(tǒng)計(jì)學(xué)意義(P<0.05);治療后,聯(lián)合組血沉水平顯著低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。聯(lián)合組總有效率顯著高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。 結(jié)論 頸淋巴結(jié)結(jié)核在抗結(jié)核治療基礎(chǔ)上加用小柴胡湯加減方治療能顯著提高臨床療效,促進(jìn)腫大淋巴結(jié)恢復(fù)。
[關(guān)鍵詞] 小柴胡湯加減方;頸淋巴結(jié);結(jié)核;血沉
[中圖分類號(hào)] R259;R522? ? ? ? ? [文獻(xiàn)標(biāo)識(shí)碼] B? ? ? ? ? [文章編號(hào)] 1673-9701(2019)27-0128-03
[Abstract] Objective To explore the therapeutic effect of modified Xiaochaihu Decoction on cervical lymph node tuberculosis. Methods 60 patients with cervical lymph node tuberculosis treated in our hospital from January 2016 to December 2017 were selected and randomly divided into the combination group and the control group, with each 30 cases. Patients in the control group were given antituberculosis treatment, while those in the combination group were additionally given modified Xiaochaihu Decoction. The clinical efficacy, the erythrocyte sedimentation rate before and after treatment, and the maximum transverse diameter of the lymph nodes were compared of the two groups. Results The maximum transverse diameter of the lymph nodes after treatment was smaller than that before treatment in both groups (P<0.05). After treatment, the maximum transverse diameter of the lymph nodes in the combination group was significantly smaller than that of the control group(P<0.05). The erythrocyte sedimentation rate of the two groups was lower than that before treatment, and the difference was statistically significant (P<0.05). After treatment, the erythrocyte sedimentation rate in the combination group was significantly lower than that in the control group, and the difference was statistically significant(P<0.05). The total effective rate of the combination group was significantly higher than that of the control group, and the difference was statistically significant(P<0.05). Conclusion Modified Xiaochaihu Decoction added to antituberculosis treatment against cervical lymph node tuberculosis can significantly improve clinical efficacy and promote the recovery of enlarged lymph nodes.
[Key words] Modified Xiaochaihu Decoction; Cervical lymph node; Tuberculosis; Erythrocyte sedimentation rate
頸淋巴結(jié)結(jié)核一般發(fā)生在人體抗病能力低下時(shí)。頸淋巴結(jié)在中醫(yī)上稱為“瘰疬”,中醫(yī)認(rèn)為其病機(jī)主要是肝氣郁結(jié)、脾失健運(yùn)、痰火凝結(jié)、積聚成核[1-2]。小柴胡湯是重要的中醫(yī)方劑,具有和解少陽之功效,主治傷寒少陽病癥。近年來,有報(bào)道將小柴胡湯用于結(jié)核病治療,認(rèn)為其能夠顯著提高抗結(jié)核的療效,抑制炎癥介質(zhì)的釋放,改善預(yù)后[3]。本研究將小柴胡湯加減方用于頸淋巴結(jié)結(jié)核的治療,現(xiàn)報(bào)道如下。
綜上所述,頸淋巴結(jié)結(jié)核在抗結(jié)核治療基礎(chǔ)上加用小柴胡湯加減方治療能顯著提高臨床療效,促進(jìn)腫大淋巴結(jié)恢復(fù)。
[參考文獻(xiàn)]
[1] 藍(lán)劍,張勝男,曾顯聲,等. 貓爪草水煎劑聯(lián)合標(biāo)準(zhǔn)抗結(jié)核方案治療頸淋巴結(jié)結(jié)核療效觀察[J]. 海南醫(yī)學(xué),2018,29(21):2993-2996.
[2] 王姬,馮馬龍. 內(nèi)消瘰疬丸輔助治療頸淋巴結(jié)結(jié)核的臨床療效觀察[J]. 浙江臨床醫(yī)學(xué),2017,19(5):907-909.
[3] 顧瀏櫻. 小柴胡湯合葶藶大棗湯加減對(duì)結(jié)核性胸膜炎的療效分析[J]. 中國熱帶醫(yī)學(xué),2014,14(12):1502-1504.
[4] 國家中醫(yī)藥管理局. 中醫(yī)外科病癥診斷療效標(biāo)準(zhǔn)瘰疬療效評(píng)定[M]. 北京:中國醫(yī)藥科技出版社,2012:127.
[5] 周偉東. 頸部淋巴結(jié)結(jié)核的診斷與治療進(jìn)展[J]. 中國醫(yī)藥,2015,10(6):914-917.
[6] 尤輝,龐健健. 內(nèi)消瘰疬片聯(lián)合化療治療頸淋巴結(jié)核120例[J]. 臨床肺科雜志,2014,19(11):2103-2104.
[7] 侯廣娣. 內(nèi)消瘰疬片聯(lián)合化療治療頸淋巴結(jié)核的療效觀察[J].中西醫(yī)結(jié)合心血管病雜志(電子版),2015,3(18):54-55.
[8] 劉幸,歐陽兵,冷艷朵,等. 結(jié)核丸與左氧氟沙星等抗結(jié)核藥物聯(lián)用對(duì)耐多藥肺結(jié)核患者的療效分析[J]. 抗感染藥學(xué),2017,14(3):511-514.
[9] 劉啟如,魏嵋,方平安,等. 消瘰散治療頸部淋巴結(jié)核的臨床觀察[J].中國現(xiàn)代醫(yī)生,2017,55(22):107-109.
[10] 劉幸,歐陽兵,杜映榮,等. 內(nèi)消瘰疬丸聯(lián)合左氧氟沙星治療耐多藥肺結(jié)核的臨床療效分析[J]. 中國醫(yī)藥導(dǎo)刊,2017,19(8):787-790.
[11] 鈕曉紅,黃子慧,楊春睿. 瘰疬寧治療淋巴結(jié)核臨床研究[J]. 中醫(yī)學(xué)報(bào),2014,29(3):399-401.
[12] 周敏,李鳧堅(jiān),黃麗琴,等. 消瘰合劑Ⅰ號(hào)聯(lián)合西藥治療頸淋巴結(jié)核患者43例療效觀察[J]. 中醫(yī)雜志,2014, 55(19):1656-1659.
[13] 江茜,周玲霞,金紅玉. 中藥內(nèi)服外敷治療頸淋巴結(jié)核的療效觀察[J]. 中國中醫(yī)藥科技,2015,22(6):660-661.
[14] 米曉燕,寧寶華,張琳,等. 中西醫(yī)結(jié)合治療頸淋巴結(jié)結(jié)核的療效觀察[J]. 吉林醫(yī)學(xué),2015,36(15):3240-3241.
[15] 李展謀. 抗結(jié)核藥物加貓爪草治療頸淋巴結(jié)核23例的療效研究[J]. 中國實(shí)用醫(yī)藥,2016,11(20):191-192.
[16] 方斐,郎雅珍,金姍姍,等. 中藥外敷聯(lián)合抗結(jié)核藥物治療淋巴結(jié)結(jié)核51例療效觀察[J]. 中國現(xiàn)代醫(yī)生,2018, 56(23):61-63.
[17] 朱江春,付義,張樂,等. 滇重樓散外敷聯(lián)合抗結(jié)核藥治療淺表淋巴結(jié)結(jié)核的近期療效[J]. 昆明醫(yī)科大學(xué)學(xué)報(bào),2018,39(1):81-84.
[18] 吳福倉,鄭輝,李曉華,等. 自擬五蟲散結(jié)膏外敷配合抗結(jié)核藥物治療淋巴結(jié)結(jié)核的臨床研究[J]. 中國實(shí)用醫(yī)藥,2017,12(29):107-109.
[19] 米曉燕,寧寶華,張琳,等. 中西醫(yī)結(jié)合治療頸淋巴結(jié)結(jié)核的療效觀察[J]. 吉林醫(yī)學(xué),2015,36(15):3240-3241.
[20] 麻莉,門九章,李霞.小柴胡湯加減治療結(jié)核變態(tài)反應(yīng)性疾病[J]. 光明中醫(yī),2011,26(3):463-464.
(收稿日期:2019-01-08)