劉楠

【摘要】 目的 分析益生菌聯(lián)合阿奇霉素治療小兒急性腸胃炎的臨床療效。方法 140例小兒急性腸胃炎患兒， 采用雙盲隨機(jī)法分為觀察組與對照組， 各70例。對照組采用阿奇霉素治療， 觀察組在對照組基礎(chǔ)上聯(lián)合益生菌治療。觀察并比較兩組癥狀（腹痛、腹瀉、發(fā)熱、嘔吐）緩解時(shí)間、臨床療效、住院時(shí)間以及不良反應(yīng)（嗜睡、高熱、皮疹）發(fā)生情況。結(jié)果 觀察組患兒腹痛、腹瀉、發(fā)熱、嘔吐緩解時(shí)間分別為（3.2±1.1）、（4.1±1.3）、（2.1±1.2）、（3.1±1.2）d， 均短于對照組的（7.5±2.3）、（8.2±3.1）、（7.2±2.4）、（8.2±3.2）d， 差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。觀察組患兒治療總有效率為98.57%， 高于對照組的80.00%， 差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。觀察組患兒住院時(shí)間為（5.2±1.2）d， 短于對照組的（9.5±2.4）d， 差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。觀察組患兒不良反應(yīng)發(fā)生率為4.29%（3/70）， 低于對照組的25.71%（18/70）， 差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 針對小兒急性腸胃炎采用益生菌聯(lián)合阿奇霉素治療的療效顯著， 可快速緩解患兒各種臨床癥狀， 不良反應(yīng)較少， 可促進(jìn)患兒病情康復(fù)， 且安全性較高， 值得臨床應(yīng)用推廣。

【關(guān)鍵詞】 小兒急性腸胃炎;益生菌;阿奇霉素;聯(lián)合治療;臨床療效

DOI：10.14163/j.cnki.11-5547/r.2019.21.046

【Abstract】 Objective? ?To analyze the clinical efficacy of probiotics combined with azithromycin in the treatment of pediatric acute gastroenteritis. Methods? ?A total of 140 acute gastroenteritis children were divided by random double-blind method into observation group and control group， with 70 cases in each group. The control group was treated with azithromycin and the observation group was treated with probiotics on the basis of the control group. Observation and comparison were made on symptoms （abdominal pain， diarrhea， fever， vomiting） remission time， clinical efficacy， hospitalization time and occurrence of adverse reactions （drowsiness， fever， rash） between the two groups. Results? ?The observation group had shorter remission time of abdominal pain， diarrhea， fever and vomiting respectively as （3.2±1.1）， （4.1±1.3）， （2.1±1.2） and （3.1±1.2） d than （7.5±2.3）， （8.2±3.1）， （7.2±2.4） and （8.2±3.2） d in the control group， and their difference was statistically significant （P<0.05）. The observation group had higher total treatment effective rate as 98.57% than 80.00% in the control group， and the difference was statistically significant （P<0.05）. The observation group had shorter hospitalization time as （5.2±1.2） d?than （9.5±2.4） d in the control group， and the difference was statistically significant （P<0.05）. The observation group had lower incidence of adverse reactions as 4.29%（3/70） than 25.71%（18/70） in the control group， and the difference was statistically significant （P<0.05）. Conclusion? ?Probiotics combined with azithromycin shows remarkable effect for children with acute gastroenteritis， and it can quickly alleviate various clinical symptoms of children with fewer adverse reactions， promote the rehabilitation of children with high safety. It is worthy of clinical application and promotion.