陸秀偉 楊娟

[關(guān)鍵詞] 肝硬化;腎損傷;危險(xiǎn)因素;腹水;肝性腦病;高血壓;糖尿病

[中圖分類號] R657.31? ? ? ? ? [文獻(xiàn)標(biāo)識碼] B? ? ? ? ? [文章編號] 1673-9701（2021）19-0096-04

Analysis on the risk factors of cirrhosis combined with renal damage

LU Xiuwei? ?YANG Juan

Department of Hepatology， Xixi Hospital of Hangzhou City， Hangzhou? ?310023， China

[Abstract] Objective To investigate the risk factors of cirrhosis combined with renal damage. Methods The clinical data of 100 patients with hepatic cirrhosis diagnosed and treated in our hospital from January 2017 to December 2019 were selected for the study. According to whether the patients had renal damage， they were divided into the renal damage group and the no renal damage group. The general data of the patients， complications， ascites condition， hepatic encephalopathy condition and others were recorded， and the risk factors for hepatic cirrhosis combined with renal damage were analyzed by univariate and multivariate analysis. Results Univariate analysis showed that patients with aged≥60 years， CTP grade C， complications of hypertension， diabetes， hyperuricemia， exposure history of contrast media， and hepatic encephalopathy had a higher probability of renal damage（P<0.05）. Multivariate analysis showed that patients with age≥60 years， CTP grade C， complications of hypertension， diabetes， hyperuricemia， and PVD>12.5 mm were the independent risk factors for patients with hepatic cirrhosis complicated with renal damage（P<0.05）. Conclusion Renal damage may occur in patients with hepatic cirrhosis. Age， CTP grade C， complications of hypertension， diabetes， hyperuricemia， and PVD widening are the independent risk factors for patients with hepatic cirrhosis complicated with renal damage.

[Key words] Hepatic cirrhosis; Renal damage; Risk factors; Ascites; Hepatic encephalopathy; Hypertension; Diabetes

肝硬化是由不同原因引起的慢性、進(jìn)行性、彌漫性肝臟病變，主要病理變化為肝細(xì)胞廣泛壞死，在此基礎(chǔ)上出現(xiàn)纖維組織彌漫性增生。在肝失代償期，除了肝功能減退，還會出現(xiàn)消化道癥狀，如出血、貧血、內(nèi)分泌失調(diào)、感染、肝性腦病、電解質(zhì)紊亂等。而肝硬化性腎損害是常見的并發(fā)癥之一，主要表現(xiàn)為腎小球病變、腎小管酸中毒，嚴(yán)重者出現(xiàn)肝腎綜合征，此外，肝炎后肝硬化患者?？沙尸F(xiàn)乙肝或丙肝相關(guān)性腎炎的表現(xiàn)，如膜增殖性腎炎、膜性腎病、毛細(xì)血管內(nèi)增生性腎炎、腎小球硬化等[1-2]。本研究旨在探討肝硬化患者發(fā)生腎損害的相關(guān)因素，以期為臨床值提供參考，現(xiàn)報(bào)道如下。

1 資料與方法

1.1 一般資料

選擇2017年1月至2019年12月我院診斷治療的肝硬化患者100例的臨床資料進(jìn)行研究。納入標(biāo)準(zhǔn)：年齡≥18周歲，符合肝硬化診斷標(biāo)準(zhǔn)[3]，合并或未合并腎臟損害，臨床資料完整，患者及其家屬對本研究知情同意。排除標(biāo)準(zhǔn)[3]：急性腎臟原發(fā)性疾病或繼發(fā)于其他疾病的腎臟疾病者;合并有免疫系統(tǒng)疾病者;認(rèn)知功能障礙者;近期應(yīng)用糖皮質(zhì)激素者;妊娠期或哺乳期者。患者一般資料見表1。本研究經(jīng)醫(yī)院醫(yī)學(xué)倫理委員會同意。

1.2 方法

1.2.1 記錄指標(biāo)? ①CTP分級[4]：根據(jù)患者白蛋白、凝血酶原時(shí)間、血清總膽紅素水平進(jìn)行評分，5～6分為A級，7～9分為B級，≥10分為C級，級數(shù)越高表示患者病情越重。②腎功能評價(jià)[4]：計(jì)算患者eGFR，<60 mL/（min·1.73 m2）為存在腎損害。③記錄患者年齡、性別、既往病史（高血壓、糖尿病、泌尿系結(jié)石、高尿酸血癥）、是否應(yīng)用造影劑史，記錄入院時(shí)患者病情、門靜脈主干內(nèi)徑（PVD）、是否合并腹水、是否合并肝性腦病。