陳培忠

[摘要] 目的 探討泮托拉唑四聯(lián)法不同療程對(duì)胃潰瘍合并糖尿病患者的療效及復(fù)發(fā)率的影響。方法 納入50例2017年5月—2018年5月該院胃潰瘍合并糖尿病患者開(kāi)展研究，所有患者均采用泮托拉唑、克拉霉素、阿莫西林、果膠鉍四聯(lián)法治療，按隨機(jī)排列法選出25例列為對(duì)照組：1個(gè)療程;剩余25例列為研究組：3個(gè)療程;比較兩組對(duì)臨床療效及復(fù)發(fā)率的影響。結(jié)果 研究組總有效率為92.00%，高于對(duì)照組的76.00%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）;兩組治療結(jié)束1個(gè)月后Hp陽(yáng)性率差異無(wú)統(tǒng)計(jì)學(xué)意義（P>0.05），治療結(jié)束1年后研究組Hp陽(yáng)性率及復(fù)發(fā)率均低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）;兩組血糖水平對(duì)比，治療前差異無(wú)統(tǒng)計(jì)學(xué)意義（P>0.05），治療后，研究組空腹及餐后2 h血糖均低于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 在胃潰瘍合并糖尿病患者的治療中，泮托拉唑四聯(lián)法3個(gè)療程療效優(yōu)于1個(gè)療程，可提高臨床有效率，降低Hp陽(yáng)性率及復(fù)發(fā)率，有效控制患者血糖水平，值得推廣。

[關(guān)鍵詞] 泮托拉唑;四聯(lián)法;不同療程;胃潰瘍;糖尿病

[中圖分類號(hào)] R4? ? ? ? ? [文獻(xiàn)標(biāo)識(shí)碼] A? ? ? ? ? [文章編號(hào)] 1672-4062（2020）01（b）-0092-03

[Abstract] Objective To investigate the effect of pantoprazole quadruple therapy on the efficacy and recurrence rate of patients with gastric ulcer and diabetes mellitus. Methods A total of 50 patients with gastric ulcer and diabetes mellitus were enrolled in the hospital from May 2017 to May 2018. All patients were treated with pantoprazole， clarithromycin， amoxicillin and pectin were randomly selected. Listed as the control group： 1 course of treatment; the remaining 25 cases were included in the study group： 3 courses; the effects of the two groups on clinical efficacy and recurrence rate were compared. Results The total effective rate of the study group was 92.00%， which was higher than 76.00% of the control group，and the difference was statistically significant（P<0.05）. There was no statistically significant difference in Hp positive rate after 1 month of treatment（P<0.05）. The Hp positive rate and recurrence rate of the study group 1 year after the end of treatment. The blood glucose levels were lower than those in the control group，and the difference was statistically significant（P<0.05）. There was no statistically significant difference between the two groups （P>0.05）. After treatment， the blood glucose of the study group was lower than that of the control group，and the difference was statistically significant（P<0.05）. Conclusion In the treatment of patients with gastric ulcer and diabetes， the pantoprazole quadruple method is better than one course of treatment， which can improve clinical efficiency， reduce Hp positive rate and recurrence rate， and effectively control blood glucose level of patients. It is worthy of promotion.

[Key words] Pantoprazole; Quadruple method; Different courses of treatment; Gastric ulcer; Diabetes]

糖尿病是一種代謝性疾病，屬慢性病范疇，由于內(nèi)分泌紊亂引起，胰島素分泌過(guò)少或作用障礙造成高血糖。糖尿病患者因其血糖長(zhǎng)期處于高值，伴有血液黏度的升高，造成胃、十二指腸發(fā)生循環(huán)障礙，進(jìn)而黏膜發(fā)生壞死，降低細(xì)胞再生性功能，從而引起胃潰瘍等胃腸道疾病。糖尿病合并胃潰瘍的發(fā)生會(huì)加重病情的發(fā)展，不利于原發(fā)病的預(yù)后，故應(yīng)采取有效的治療方式提高臨床療效，從而提高患者的生活質(zhì)量[1]。泮托拉唑是臨床上常用的質(zhì)子泵抑制劑，該次以該院于2017年5月—2018年5月收治的50例胃潰瘍合并糖尿病患者為對(duì)象，就克拉霉素、阿莫西林、果膠鉍四聯(lián)法的不同療程對(duì)臨床療效及復(fù)發(fā)率的影響展開(kāi)討論，現(xiàn)報(bào)道如下。