嵇秀麗

【摘要】 目的 探討復方阿嗪米特腸溶片治療膽源性消化不良的臨床效果。方法 60例膽源性消化不良患者， 按照隨機數(shù)字法分為對照組和觀察組， 每組30例。對照組患者采用消炎利膽片治療， 觀察組患者采用復方阿嗪米特腸溶片治療。比較兩組患者臨床癥狀改善時間、治療后胃腸癥狀評估量表（GSRS）評分以及不良反應發(fā)生率。結(jié)果 觀察組患者腹脹、惡心、嘔吐癥狀改善時間分別為（12.32±

3.39）、（7.64±1.37）、（7.23±2.36）d均明顯短于對照組的（14.28±3.69）、（8.36±1.15）、（8.44±1.54）d， 差異具有統(tǒng)計學意義（P<0.05）。治療后， 觀察組患者GSRS評分均明顯低于對照組， 差異具有統(tǒng)計學意義（P<0.05）。觀察組患者不良反應發(fā)生率為6.67%， 明顯低于對照組的26.67%， 差異具有統(tǒng)計學意義（P<0.05）。結(jié)論 復方阿嗪米特腸溶片治療膽源性消化不良效果較好， 可有效改善患者臨床癥狀， 降低不良反應發(fā)生率， 提高患者生活質(zhì)量， 值得臨床推廣應用。

【關(guān)鍵詞】 復方阿嗪米特腸溶片；膽源性消化不良；消炎利膽片

DOI：10.14163/j.cnki.11-5547/r.2018.14.007

Analysis of effect of compound azintamide enteric-coated tablets in the treatment of patients with biliary dyspepsia JI Xiu-li. Inner Mongolia Hulunbeier Peoples Hospital， Hulunbeier 021008， China

【Abstract】 Objective To discuss the clinical effect of compound azintamide enteric-coated tablets in the treatment of patients with biliary dyspepsia. Methods A total of 60 patients with biliary dyspepsia were divided by random number table method into control group and observation group， with 30 cases in each group. The control group was treated with inflammation-resolving gall-bladder-excreting tablet， and the observation group was treated with compound azintamide enteric-coated tablets. Comparison were made on clinical symptom improvement time， gastrointestinal symptom rating scale （GSRS） score and incidence of adverse reactions between the two groups. Results The observation group obviously shorter abdominal distension， nausea， vomiting symptoms improvement time as （12.32±3.39）， （7.64±1.37） and （7.23±2.36） d than （14.28±3.69）， （8.36±1.15） and （8.44±1.54） d in control group， and the difference was statistically significant （P<0.05）. After treatment， the observation group had obviously lower GSRS score than the control group， and the difference was statistically significant （P<0.05）. After treatment， the observation group had obviously lower incidence of adverser reactions as 6.67% than 26.67% in the control group， and the difference was statistically significant （P<0.05）. Conclusion Compound azintamide enteric-coated tablets shows excellent effect in treating biliary dyspepsia， and it can effectively improve the clinical symptom，

reduce incidence of adverse reactions， and improve the quality of life. It is worthy of clinical promotion and application.

【Key words】 Compound azintamide enteric-coated tablets； Biliary dyspepsia； Inflammation-resolving gall-bladder-excreting tablet

膽源性消化不良是消化內(nèi)科常見的疾病類型， 主要是由多種膽道疾病所導致的膽汁儲存、濃縮以及排出出現(xiàn)障礙， 致使膽汁量明顯不足， 消化酶分泌不斷減少且活性不斷下降所引起的器質(zhì)性消化不良[1]?；颊咭话銜霈F(xiàn)食欲不振、早飽、食后腹脹、腹部疼痛、噯氣以及腹瀉等癥狀， 并且無明顯怕冷、畏寒以及發(fā)熱現(xiàn)象發(fā)生， 其發(fā)生多與人們的生活習慣以及飲食習慣變化有關(guān)， 發(fā)病率較高且呈現(xiàn)出逐年上升的趨勢， 對患者的身心健康以及日常生活均有嚴重影響， 需要及時采取有效治療來改善患者預后， 提高生活質(zhì)量[2]。臨床一般采用藥物治療， 復方阿嗪米特腸溶片治療膽源性消化不良效果較好且不良反應較少， 可促進患者癥狀快速緩解[3]。本次研究主要探討復方阿嗪米特腸溶片治療膽源性消化不良的臨床效果， 現(xiàn)報告如下。