葉浩+晏雪+丁國林
[摘要] 目的 研究分析依達(dá)拉奉治療對顱內(nèi)動脈瘤患者顯微術(shù)后神經(jīng)功能的改善效果。 方法 試驗(yàn)中方便選取該院2013年5月—2016年10月收治的72例顱內(nèi)動脈瘤患者,將全部患者隨機(jī)分成研究組與對照組,均為36例;入選患者均行顯微夾閉術(shù)進(jìn)行治療,對照組在手術(shù)后實(shí)施常規(guī)治療,研究組在常規(guī)治療的基礎(chǔ)上聯(lián)用依達(dá)拉奉,觀察分析患者的神經(jīng)功能改善情況、大腦中動脈血流速度(VMCA)及其預(yù)后情況等。結(jié)果 全部入選患者的治療均完成后,在術(shù)后4周,研究組的NIHSS評分為(3.63±1.37)分,對照組為(5.75±1.46)分,研究組明顯低于對照組(P<0.05),且在術(shù)后4周,研究組的VMCA為(74.80±5.20),BMI評分為(86.35±9.71)分,對照組分別為(85.20±5.80),(65.38±8.68)分,組間對比,研究組均優(yōu)于對照組(P<0.05);不良反應(yīng)發(fā)生情況分析對比,研究組(2.78%)較對照組(16.67%)也明顯減少(P<0.05)。結(jié)論 顱內(nèi)動脈瘤患者在行顯微術(shù)后給予依達(dá)拉奉進(jìn)行治療,具有顯著的臨床效果,能夠?qū)颊叩纳窠?jīng)功能進(jìn)行有效的改善。
[關(guān)鍵詞] 依達(dá)拉奉;顱內(nèi)動脈瘤;顯微術(shù);神經(jīng)功能
[中圖分類號] R651 [文獻(xiàn)標(biāo)識碼] A [文章編號] 1674-0742(2017)02(b)-0143-03
[Abstract] Objective To research the edaravone treatment for patients with intracranial aneurysm on the improvement of neurologic function after the microscopy. Methods Convenient selection 72 cases of patients with intracranial aneurysm admitted and treated in our hospital from May 2013 to October 2016 were selected and randomly divided into two groups with 36 cases in each, all selected patients were treated with microsurgical clip occlusion, and the control group adopted the routine treatment after operation, while the research group adopted the edaravone on the basis of the routine treatment, and the improvement of neurologic function and VMCA and prognosis of patients were observed and analyzed. Results After treatment, the NIHSS score in the research group was obviously lower than that in the control group at 4 weeks after operation[(3.63±1.37)points vs(5.75±1.46)points],(P<0.05), and the VMCA and BMI scores in the research group were better than those in the control group[(74.80±5.20),(86.35±9.71)points vs (85.20±5.80), (65.38±8.68)points](P<0.05) and the occurrence of adverse reactions in the research group was obviously lower than that in the control group(2.78% vs 16.67%)(P<0.05). Conclusion The clinical effect of edaravone treatment for patients with intracranial aneurysm after the microscopy is obvious, which can effectively improve the neurologic function of patients.
[Key words] Edaravone; Intracranial aneurysm; Microscopy; Neurologic function
顱內(nèi)動脈瘤在臨床上比較常見,其具有較高的死亡率及殘疾率等,同時(shí)其也是導(dǎo)致蛛網(wǎng)膜下腔出血的主要原因,對于患者的危害性極大[1-2]。而患者術(shù)后常常也會出現(xiàn)多種并發(fā)癥,影響其術(shù)后恢復(fù)及神經(jīng)功能等,因此,給予患者安全有效的術(shù)后治療尤為重要[3-4]。為了提高患者的治療效果,該文方便選取2013年5月—2016年10月間在該院行顯微術(shù)治療的72例顱內(nèi)動脈瘤患者,探討分析依達(dá)拉奉對于患者術(shù)后神經(jīng)功能的改善效果,現(xiàn)報(bào)道如下。
1 資料與方法
1.1 一般資料
試驗(yàn)對象來自于在該院行顯微夾閉術(shù)進(jìn)行治療的顱內(nèi)動脈瘤患者,共方便選取72例,并將入選對象隨機(jī)分成研究組(n=36例)與對照組(n=36例);研究組中男19例,女17例,年齡范圍在39~76歲之間,中位年齡(55.37±6.03)歲,腫瘤直徑在2.64~13.73 mm之間,平均為(6.06±1.74)mm;對照組中男20例,女16例,年齡范圍在38~77歲之間,中位年齡(56.02±6.32)歲,腫瘤直徑在2.48~13.81 mm之間,平均為(6.14±1.52)mm;分析比較患者的基線資料,差異無統(tǒng)計(jì)學(xué)意義(P>0.05),具有可比性。