段恩奎 雷曉華

摘 要：隨著空間生命科學(xué)研究的發(fā)展，人們將細(xì)胞、組織培養(yǎng)技術(shù)與微重力環(huán)境相結(jié)合產(chǎn)生了組織工程研究的一個(gè)新領(lǐng)域—微重力組織工程。模擬太空微重力條件下細(xì)胞培養(yǎng)和組織構(gòu)建研究表明，微重力環(huán)境有利于細(xì)胞的三維生長，形成具有功能的組織樣結(jié)構(gòu)，培養(yǎng)后的三維組織無論從形態(tài)上還是基因表達(dá)上都更接近于正常的機(jī)體機(jī)體組織。這種微重力對(duì)細(xì)胞的作用效應(yīng)，將可能為未來組織工程和再生醫(yī)學(xué)研究提供一條新途徑。

關(guān)鍵詞：微重力 生物反應(yīng)器 細(xì)胞培養(yǎng) 組織工程

Abstract：Along with the development of space biology， the technique of tissue and cell culture under microgravity is becoming a new research filed， which has been known as microgravity tissue engineering. The study of microgravity or simulated microgravity on cells and tissues culture indicated that microgravity could offer a special effects on forming three-dimension （3-D） tissue structure and functional tissues. The 3-D tissue constructs generated on microgravity conditions exhibit more similar phenotypes in either morphous or gene expression profiles to those in normal tissues in vivo.

Key Words：Microgravity；Bioreactor；Cell culture；Tissue engineering

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