2 Acupuncture

2015006 Effect of electro-acupuncture on m etabolites in the cerebral cortex of ulcerative colitis rats based on Pi/Wei-Brain related theory.YANG Yang（楊陽），et al.Acupunct&Massage Coll，Chengdu TCM Univ，Chengdu 610075.Chin J Integr Tradit& West Med 2014；34（10）：1207-11.

ObjectiveTo study the effectof electro-acupuncture（EA）at points along Foot Yangming Channel on metabolite of ulcerative colitis（UC）rats'cerebral cortex and to identify key metabolites by referring to Pi/Wei-brain related theory in Chinesemedicine（CM）.MethodsThe UC ratmodelwas setup by dextran sulfate sodium（DSS）method.Male SD rats were randomly divided into the model group and the EA group，13 in each group.Another 13 rats were recruited as the blank control group. Rats in the blank control group and the model group received no EA.EA was performed at Zusanli（ST36），Shangjuxu（ST37），and Tianshu（ST25）for 5 days by using disperse-densewave.Then all ratswere sacrificed. Their recto-colon and the ileocecal junction were pathomorphologically observed by lightmicroscope and transmission electron microscope（TEM）.Cerebral cortexes were extracted.Water-soluble and lipid-soluble brain tissue metabolites were respectively extracted for metabolic research using1H nuclear magnetic resonance（1HNMR）.ResultsEA could obviously improve the general condition of UCmodel rats，decrease the value of DAI，reduce the infiltration of inflammatory cells in the intestinal tract，stabilize structures such as mitochondria，endoplasmic reticulum and so on（P＜0.05）.1HNMR analysis showed that in themodel group，contents of glutamic acid，cholesterol，very low density lipoprotein（VLDL）in the pallium obviously decreased，while alanine and low density lipoprotein（LDL）significantly increased.After EA，levels of lactic acid，glutamic acid，total cholesterol（TC），and VLDL all increased，and levels of alanine and LDL decreased.All indices were approximate to those of the blank control group.ConclusionEA at Foot Yangming channelwas found to have some effect on metabolites in the brain tissue of UC model rats，which had specific metabonomic material basis and mechanism based on the Pi/Wei-brain related theory.

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2015007 Effect of acupuncture at pericardium points of amplitude of low frequency fluctuations of healthy people in resting state functional magnetic resonance im aging.ZHOU Youlong（周友龍），et al. Dept Acupunct&Moxibust，3rd AffilHosp，Henan TCM Coll，Zhengzhou 450008.Chin J Integr Tradit&West Med 2014；34（10）：1197-01.

Ob jectiveTo observe the effect of acupuncture at the whole points of Hand Jueyin pericardium meridian on the amplitude of low frequency fluctuations（ALFF）of healthy people in resting state（R1）functionalmagnetic resonance imaging（fMRI）.M ethodsTotally 16 healthy subjects received structure scan of T1 and T2.Then two fMRI scans were conducted for each participant.fMRI included the resting-state scan（R1；the scanning time was 8 min 6 s），the stimulating-acupoint scan（AP；the scanning time was8 min 6 s）.fMRIdata from structure scanning and function scanning were processed with format conversion and statistical analysis.ResultsUnder R1 state，brain regions with activated ALFF signals included bilateral superior frontal gyrus，medial frontal gyrus，middle occipital gyrus，precuneus，superior temporal gyrus，and cingulate gyrus.Under the AP state，brain regions with activated ALFF signals were bilateral superior frontal gyrus，medial frontal gyrus，middle temporal gyrus，left fusiform gyrus，precuneus，posterior cingulate，and declivis.Compared with R1 state，obvious difference of ALFF signal areas of the brain caused by acupuncture at pericardium were：bilateral cuneus，precuneus，left posterior cingulate gyrus，right middle occipital gyrus，and right occipital lingual gyrus.ConclusionAcupuncture at the whole points of Hand Jueyin pericardium meridian could significantly change inherent activity states of the cerebral cortex，especially in bilateral superior frontal gyrus，medial frontal gyrus，and precuneus.

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2015008 Effects of electroacupuncture on chem otherapy-induced nausea and vom iting and itsmechanism.ZHANG Xing（張興），etal.Dept Gastroenterol，1st Affil Hosp，China Med Univ，Hangzhou 310006. Chin Acupunct&Moxibust 2014；34（11）：1061-64.

Ob jectiveTo observe the effects of electroacupuncture at Neiguan（PC 6）and Jianshi（PC 5）combined with granisetron on nausea and vomiting aswell as serum levels of 5-hydroxy tryptamine（5-HT）and dopamine（DA）in chemotherapy patients.M ethodsSeventy-two chemotherapy patientswhomet the inclusive criteria were random ly divided into an observation group（38 cases）and a control group（34 cases）.The patients in the observation group were treated with electroacupuncture at Neiguan（PC 6）and Jianshi（PC 5）combined with granisetron injection；the patients in the control group were treated with electroacupuncture at sham-point 1 and sham-point 2，and the rest treatmentwas identical to the observation group.After3-day treatment，the clinical indices including times of vomiting and severity of nausea，etc.were observed in the two groups.Resu lts①At the acute stage within 24 h，the times of vomiting in the two groupswere not significantly different（P＞0.05）；at the delay stage，the severity ofnauseawas significantly higher in the control group（P＜0.05）.②As for the comprehensive efficacy and rate of complete control，there was no obvious difference between the two groups at the acute stage（P＞0.05）；while in the delay stage，the rate of complete control in the observation group was superior to that in the control group（P＜0.01）.③Compared before and after the treatment，serum levels of 5-HT and DA were evidently reduced in the observation group（both P＜0.05），while those in the control group did not significantly change after treatment（both P＞0.05）.ConclusionElectroacupuncture at Neiguan（PC 6）and Jianshi（PC 5）combined with granisetron could obviously relieve the nausea in chemotherapy patients at the delay stage.Themechanism is possibly related to reducing the contentof5-HT and DA.

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2015009 Efficacy on border line hypertension treated with acupuncture combined with anti-hypertensive plaster intervention.LIYanmei（李艷梅），Shandong TCM Acad，Jinan 250014.Chin Acupunct&Moxibust 2014；34（11）：1057-60.

ObjectiveTo compare the efficacy difference in treatmentof borderline hypertension between acupuncture combined with anti-hypertensive plaster and simple acupuncture.M ethodsSixty patients of borderline hypertension were randomized into an observation group and a control group，30 cases in each one.In the observation group，acupuncture was applied to Fengchi（GB 20），Taichong（LR 3）and the others，once a day，5 courses of treatmentmade one session.There were 2 days at interval among the sessions.Totally，4 sessions were required.Additionally，in combination，the anti-hypertensive plasterwas prepared with the fine powder of Chuanxiong（ligusticum wallichii）and Wuzhuyu（fructus evodiae）at1∶1 and mixed with vinegar.The plaster was applied to the umbilicus，once every two days，totally 15 times were required.In the control group，acupuncture was given simply.The selected acupoints and operation were the same as the observation group.Before and after treatment，blood pressure and syndrome score were observed and the short-term and long-term efficacies were assessed in the two groups.ResultsAfter treatment，the systolic pressure and diastolic pressure were reduced as compared with those before treatment in the two groups（all P＜0.001），and the differences were significant in comparison between the observation group and the control group（P＜0.01，P＜0.05）.The syndrome score after treatmentwas reduced as compared with that before treatment in the two groups（both P＜0.001）and the difference was not significant in comparison between the two groups（P＞0.05）.In follow-up of the effective cases and remarkably effective cases in 3 months，the total effective rate in the observation group was89.3%（25/28）and was60.0%（15/25）in the control group，indicating the significant difference（P＜0.05）.ConclusionAcupuncture combined with anti-hypertensive plaster is the effective method in prevention and treatment of borderline hypertension.Regarding the long-term efficacy，this combined therapy achieves the superior improvement in the symptoms and physical signs of the patients of borderline hypertension as compared with simple acupuncture.

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2015010 Acupuncture and drug for subcortical ischem ic vascular disease complicated with depression：a random ized controlled trial.XIAOWei（肖偉），et al.12th Ward，2nd Affil Hosp，Anhui TCM Univ，Hefei 230061.Chin Acupunct&Moxibust，2014；34（11）：1051-56.

ObjectiveTo explore the difference in the efficacy and effect mechanism of subcortical ischemic vascular disease（SIVD）complicated with depression between acupuncture and medication.M ethodsSixty patients were randomized into an acupuncture group and a medication group，30 cases in each.In the acupuncture group，acupuncture was applied to Baihui（GV 20），Shuigou（GV 26），F(xiàn)engfu（GV 16），F(xiàn)engchi（GB 20）and the others，once a day，6 times a week.The treatment of 4 weeks made one session and totally 2 sessionswere required.In the medication group，nimodipine 30 mg，three times a day and fluoxetine20mg，once a daywere prescribed for oral administration，for 8 weeks totally.Before treatment，at the end of the 4th week and at the end of the 8th week of treatment，cerebral blood flow velocity（CBFV）and solubility CD40 ligand（sCD40L）were determined respectively.The scores in Montreal cognitive assessment（MoCA）and Hamilton's depression scale（HAMD）were evaluated in the two groups.The efficacies on cognitive function and depression symptoms were compared in patients between the two groups.ResultsCompared with the outcome before treatment，mean blood flow velocity（Vm）of middle cerebral artery（MCA），anterior cerebral artery（ACA）and posterior cerebral artery（PCA）was increased significantly at the end of the 4th week of treatment in the two groups（all P＜0.05）.At the end of the 8th week，Vm was increased much significantly（all P＜0.01）.The differenceswere not significant in comparison between the two groups（all P＞0.05）.Compared with the expression before treatment，sCD40L was reduced significantly after treatment in patients of the two groups（all P＜0.01），but the difference was not significant between the two groups（all P＞0.05）.Compared with that before treatment，MoCA score was increased significantly after treatment in the two groups（all P＜0.01），HAMD scorewas reduced significantly（all P＜0.01），the differences were not significant in comparison between the two groups（all P＞0.05）.The total effective rate of cognitive improvement was 86.7%（26/30）in the acupuncture group and was 80.0%（24/30）in the medication group，the differences were not significant in comparison of the two groups（P＞0.05）.The total effective rate of the improvement in depression was 93.3%（21/30）in the acupuncture group and was 86.7%（26/30）in the medication group，the differences were not significant in comparison of the two groups（P＞0.05）.ConclusionAcupuncture could significantly increases CBFV and reduces serum sCD40L expressions in patients of SIVD complicated with depression，and significantly improves cognitive function and relieves depression symptoms.The efficacy of it is similar to thatofwesternmedication.The increase of serum sCD40L expression is possibly involved in the occurrence and development of SIVD.Reducing sCD40L expression contributes to the alleviation of damage induced by cerebral ischemia and reperfusion.

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2015011 Im pacts of yin-yangmeridians acupuncture w ith respiratory reinforcing and reducing manipulation on lower limbs balance function in stroke patients.TIAN Fuling（田福玲），et al.TCM Coll，Hebei United Univ，Tangshan 063000.Chin Acupunct&Moxibust，2014；34（1）：1047-50.

ObjectiveTo observe the impact on lower limbs balance function in treatment of yin-yang meridians acupuncture with respiratory reinforcing and reducingmanipulation involved in patients of stroke by applying B-PHY balance function test training system so as to provide the objective evidence in treatment of stroke with acupuncture.M ethodsOne hundred patients were randomized into an observation group and a control group，50 cases in each.In the control group，the basic treatment was applied，without other relevant rehabilitation therapies associated.In the observation group，with the basic treatmentas the control group's，the therapy of the yinyang meridians acupuncutre with respiratory reinforcing and reducing manipulation was adopted.On the yin meridians，Zuwuli（LR 10），Xuehai（SP 10），Yinlingquan（SP 9），Sanyinjiao（SP 6）and the others were selected and stimulated with reducing manipulation achieved by the coordination of patient's respiration.On the yang meridians，Biguan（ST 31），Liangqiu（ST 34），Yanglingquan（GB 34）and the others were selected andstimulated with reinforcingmanipulation achieved by the coordination of patient's respiration.The treatment was given once a day and for 28 days totally.Before treatment and in 28 days of treatment，B-PHY balance function test training system was used to determine theweight shift track parameters（track length，peripheral square，track length of per unit square，left-right offset and rectangle square），the weight shift track distance parameters［mean of X axle weight shift distance（Mean-X），mean of Y axle weight shift distance（Mean-Y），maximum of X axle weight shift distance（Max-X），maximum of Y axle weight shift distance（Max-Y），weight shift distance（LSKG），weight shift square（SSKG），square ratio ofweight shift（LFS）］，stability coefficient（SI）and weight distribution coefficient（WDI）.Resu ltsAfter treatment，the differences in the weight shift track parameters，SIand WDIwere significant as compared with those before treatment in patients of the two groups（all P＜0.01）；while the differences in the weight shift distance parameters in the observation group were improved obviously after treatment as compared with those before treatment（all P＜0.01），the differences of Mean-X，Max-Y and LFS in the control group were improved after treatment as compared with those before treatment（all P＜0.01）.Except SSKG，the improvement after treatment in the rest indices in the observation group was better than that in the control group（all P＜0.05）.ConclusionThe yin-yang meridians acupuncture with respiratory reinforcing and reducing manipulation effectively improves the lower limbs balance function in patients of stroke.

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