16 Psychiatric Disorder

2015130 The in fluence of environm ent on dep ressive-like behavior of transgenic m ice.CHEN Jing（陳靜），et al.Shanghai Mental Health Center，Shanghai Jiaotong Univ Med Sch，Shanghai200030.Chin JNerve Ment Dis 2014；40（9）：547-551.

Ob jectiveTo investigate the influence of environment on despressive-like behavior in DISC1 transgenic mice.MethodsSixteen C57BL/6 wild-type mice were randomly assigned into two groups，the WT-stress group and the WT-control group.Sixteen C57BL/6 LBDDISC1 transgenic mice were also randomly assigned into 2 groups，the DISC1-stress group and the DISC1-control group.The WT-stress group and the DISC1-stress group received daily 3 h maternal separation for six consecutive days and chronic unpredictablemild stress for21 consecutive days.The sucrose consumption and the forced swimming test were used to evaluate depressive-like behaviors.The changes of bodyweightweremeasured.ResultsThere was no interaction（P＞0.05）between environment and gene associated with the preference for sucrose solution.However，the preference for sucrose solution was lower in the DISC1-stress group than in the rest 3 groups（P＜0.01）.Interaction between environment and associated with the immobility time was significant（P=0.010）in the forced swimming test.The immobility time was longer in the DISC1-stress group than in the WT-control group（P＜0.01）.The bodyweightwas lower in the DISC1-stress group than in the rest 3 groups（P＜0.01）.But the interaction of environment can gene associated with bodyweight was not significant（P＞0.05）.ConclusionThe interaction of gene and environment can induce depressive-like behavior in mice.

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