劉紅宇+++++生啟芳++++裘華敏++++楊文海++++應(yīng)申鵬
[摘要] 目的 分析宮頸癌的MRI表現(xiàn),評(píng)價(jià)MRI對(duì)宮頸癌術(shù)前診斷與分期的價(jià)值。方法 搜集本院2009年1月~2013年1月50例經(jīng)病理證實(shí)的宮頸癌患者的臨床資料和MRI資料。年齡32~75歲,平均45歲。主要臨床癥狀為陰道不規(guī)則流血,包括接觸性、性交后和絕經(jīng)后。病理診斷:鱗癌42例,腺癌6例,腺鱗癌2例。50例患者中21例行手術(shù)治療,其余行放療?;仡櫺苑治銎銶RI影像特征,觀察腫瘤的位置、大小、信號(hào)特征以及對(duì)周圍組織的侵犯情況。結(jié)果 宮頸癌MRI表現(xiàn):T1WI呈低或等信號(hào),T2WI呈高信號(hào),與正常宮頸基質(zhì)(低信號(hào))及宮旁脂肪(高信號(hào))形成良好的對(duì)比,GD-DTPA增強(qiáng)呈輕度均勻或不均勻強(qiáng)化。同時(shí)顯示宮體、宮旁、陰道、盆壁、器官侵犯及淋巴結(jié)轉(zhuǎn)移等。 結(jié)論 MRI顯示宮頸癌瘤灶、侵犯范圍與途徑,明顯優(yōu)于其他影像學(xué)檢查,對(duì)發(fā)現(xiàn)宮旁侵犯情況明顯優(yōu)于臨床,應(yīng)作為宮頸癌術(shù)前常規(guī)的影像學(xué)檢查方法。
[關(guān)鍵詞] 子宮頸癌;磁共振成像;腫瘤分期
[中圖分類號(hào)] R737.33[文獻(xiàn)標(biāo)識(shí)碼] B[文章編號(hào)] 1673-9701(2014)15-0047-03
MRI for diagnosis and staging of cervical cancer before surgery
LIU Hongyu1 SHENG Qifang2 QIU Huamin1 YANG Wenhai3 YING Shenpeng1
1.Department of Radiology, Taizhou City Center Hospital in Zhejiang Province, Taizhou 318000,China; 2.Ningbo City Yinzhou District the Second Hospital,Ningbo 315192,China;3.Department of Radiology, the First People's Hospital of Taizhou in Zhejiang Province, Taizhou 318020,China
[Abstract] Objective To analyze the value of MRI evaluation diagnosis and staging for cervical cancer. Methods Anarzed the clihical data and MRI of 50 cases pathologically confirmed cervical cancer patients. Aged 32-75 years,mean age 45 years. The main clinical symptom of irregular vaginal bleeding,included post-contact,sexual intercourse,and after menopause. Pathological diagnosis of squamous cell carcinoma in 42 cases,six cases of adenocarcinoma, adenosquamous carcinoma in 2 cases. 21 of 50 patients underwent surgical treatment,and the remaining radiotherapy.retrospectively analyzed MRI features observed tumor location,size, signal characteristics as well as violations of the surrounding tissue. Results Cervical MRI showed:T1WI showed low or equal signal, T2WI showed high signal, with normal cervical stromal(low signal) and parametrial fat(high signal) to form a good natural contrast, GD-DTPA enhancement showed mild degree homogeneous or inhomogeneous enhancement. Also showed palace,uterine,vaginal,pelvic wall,organ invasion and lymph node metastasis. Conclusion MRI of cervical tumor foci display violated the scope and ways, superior to other imaging studies,the discovery of parametrial invasion is significantly better than the clinical situation,as a former cancer eheck methods should be routine imaging methods.
[Key words] Cervical cancer ; Magnetic resonance imaging ; Tumor stage宮頸癌是女性生殖器最常見的惡性腫瘤之一,術(shù)前能否早期診斷與準(zhǔn)確分期直接關(guān)系著治療方案和預(yù)后[1]。臨床診斷是通過??茩z查或細(xì)胞學(xué)檢查,而難以確定腫瘤的侵犯途徑和范圍。有研究表明磁共振成像(Magnetic Resonance Imaging,MRI)在宮頸癌的診斷和分期中有著很重要的地位,是目前子宮頸癌宮旁侵犯及周圍器官轉(zhuǎn)移的最佳的無創(chuàng)性檢查方法,在子宮頸癌分期上的價(jià)值明顯優(yōu)于超聲和CT,但目前關(guān)于MRI診斷宮頸癌及其分期的準(zhǔn)確率卻報(bào)道不一[2]。本研究對(duì)該院2009年1月~2013年1月收集的50例經(jīng)病理證實(shí)的宮頸癌患者的臨床資料和MRI資料進(jìn)行回顧性分析,旨在探討MRI在宮頸癌術(shù)前診斷和分期中的應(yīng)用價(jià)值,現(xiàn)報(bào)道如下。
1 資料與方法
1.1 臨床資料
搜集本院2009年1月~2013年1月50例經(jīng)病理證實(shí)的宮頸癌患者的臨床資料和MRI資料,均具有完整詳細(xì)的手術(shù)記錄和病理記錄,年齡范圍32~75歲,平均年齡45歲。主要臨床癥狀為陰道不規(guī)則流血,包括接觸性、性交后和絕經(jīng)后。病理診斷為鱗癌42例,腺癌6例,腺鱗癌2例。50例患者中21例行手術(shù)治療,其余行放療。
1.2 儀器與方法
MR檢查采用GE Signa HDxt 1.5T超導(dǎo)磁共振掃描儀。MR檢查序列包括:AX T1WI FSE序列,TR 467 ms,TE 7.5 ms;AX T2WI FSE序列,TR 2250 ms,TE 95 ms;SAG T2WI FSE+FS序列,TR 4200 ms,TE 85 ms;COR STIR序列,TR 5000 ms,TE 68 ms;LAVA序列,TR 3.7 ms,TE 1.7 ms;DWI序列 TR 4500 ms,TE 75.1 ms;經(jīng)肘靜脈注射GD-DTPA 0.01 mmol/kg后,行LAVA序列3期掃描。掃描層厚除LAVA序列3 mm,其余均為6 mm。MRI圖像均由兩名副主任醫(yī)師分別閱片,根據(jù)閱片結(jié)果明確宮頸癌的MRI分期。臨床分期由婦產(chǎn)科副主任醫(yī)師根據(jù)FIGO分期分類。宮頸癌的臨床分期采用國際婦產(chǎn)科協(xié)會(huì)(FIGO)分類法 ,該分類法主要是根據(jù)陰道、宮旁、盆壁、膀胱及直腸侵犯與否進(jìn)行分期。