陳海華

[關(guān)鍵詞] 手足口病;常規(guī)治療;小兒熱速清糖漿;皮疹消失時(shí)間;退熱時(shí)間

[中圖分類號(hào)] R725.1? ? ? ? ? [文獻(xiàn)標(biāo)識(shí)碼] B? ? ? ? ? [文章編號(hào)] 1673-9701（2021）25-0143-04

Clinical effect of Xiaoer Resuqing syrup on children with hand-foot-mouth disease

CHEN Haihua

Department of Pediatrics， Huai′an Maternal and Child Health Hospital，Huai′an? ?223001，China

[Abstract] Objective To explore the clinical effect of Xiaoer Resuqing syrup in children with hand-foot-mouth disease. Methods A total of 100 children with hand-foot-mouth disease admitted to our hospital from September 2019 to September 2020 were selected and divided into the observation group （Xiaoer Resuqing syrup combined with conventional treatment， n=50） and the control group （conventional treatment， n=50） according to different treatment regimens. The clinical effect，disappearance time of clinical symptoms，C-reactive protein （CRP） level，and procalcitonin （PCT） level were recorded and compared between the two groups. Results The clinical treatment effect of the observation group was 98.0%，which was better than 76.0% of the control group， and the difference was significant （P<0.05）.The disappearance time of clinical symptoms of fever， mouth pain， rash， and anorexia in the observation group （[1.57±0.45] d， [3.14±0.71] d， [4.01±1.04] d， [1.91±0.61] d） was shorter than that in the control group （[3.71±0.67] d， [5.02±0.86] d， [5.64±1.26] d， [3.65±0.81] d）， and the difference was significant （P<0.001）. The levels of CRP and PCT in the observation group after treatment （[1.16±0.21] mg/L， [0.31±0.06] ng/mL） were lower than those in the control group （[2.32±0.39] mg/L， [0.56±0.08] ng/mL） （P<0.001）. Conclusion Xiaoer Resuqing syrup in the treatment of Children with hand-foot-mouth disease has a significant clinical therapeutic effect，which makes the disappearance time of clinical symptoms in children shorter， and the contents of CRP and PCT in children effectively reduced， which had more application value.

[Key words] Hand-foot-mouth disease; Conventional treatment; Xiaoer Resuqing syrup; Time of rash disappearance; Antipyretic time

手足口病屬于常見小兒疾病，多因腸道病毒誘發(fā)疾病[1]，臨床上常以柯薩奇病毒A16型（Coxsachie virus，Cox16）和腸道病毒71型（Enterovirus 71，EV71）最為常見[2]。該病多發(fā)于學(xué)齡前兒童，多為5歲及以下的兒童，主要是因?yàn)閮和挲g尚小，機(jī)體免疫功能尚未發(fā)育完善，對(duì)于病毒的抵抗能力還不夠強(qiáng)，所以腸道病毒入侵后，容易形成疾病[3]?；純喊l(fā)病后，會(huì)有厭食、口痛、發(fā)熱、口腔皰疹或是手足皰疹等癥狀。若患兒病情較輕，一周內(nèi)便可自愈。若患兒病情較重，則需及時(shí)進(jìn)行有效治療，預(yù)防疾病惡化，誘發(fā)心肺、神經(jīng)系統(tǒng)并發(fā)癥，如心肌炎、肺水腫等[4]。同時(shí)由于其傳播途徑較為復(fù)雜，傳播速度較快，導(dǎo)致其臨床控制難度較大[5]。因此臨床中探索有效實(shí)用的治療方法十分重要。中藥治療小兒手足口病取得了較好療效，但傳統(tǒng)煎劑湯藥口感苦，且劑量大，家長(zhǎng)喂服困難，患兒配合程度低。小兒熱速清糖漿是一種中藥糖漿制劑，口感甘甜，患兒易接受。本研究探討小兒熱速清糖漿對(duì)手足口病患兒的臨床效果，以尋求更優(yōu)的臨床治療方法。