吳孟超，中國(guó)科學(xué)院院士，2005年度國(guó)家最高科學(xué)技術(shù)進(jìn)步獎(jiǎng)獲得者，我國(guó)肝癌研究的開(kāi)創(chuàng)人之一，生于福建閩清縣，1940年自馬來(lái)西亞歸國(guó)。吳教授1949年畢業(yè)于同濟(jì)大學(xué)醫(yī)學(xué)院。他是海軍軍醫(yī)大學(xué)(原第二軍醫(yī)大學(xué))一級(jí)教授，博士生導(dǎo)師，一位杰出的醫(yī)學(xué)科學(xué)家，中國(guó)肝膽外科的主要奠基人之一。

吳教授提出了“五葉四段”的肝解剖學(xué)理論; 建立了“常溫下間歇肝門阻斷止血技術(shù)”，提供了糾正肝癌術(shù)后常見(jiàn)的致命性生化代謝紊亂的新策略; 提出了“二期手術(shù)”的概念，為晚期肝癌開(kāi)辟了一條新的治療途徑。

吳教授組建了國(guó)際上大規(guī)模的肝臟外科專業(yè)研究所，牽頭指導(dǎo)了一系列具有國(guó)際先進(jìn)水平的基礎(chǔ)研究工作，研制了細(xì)胞融合和雙特異性單抗修飾兩種腫瘤疫苗，發(fā)明了攜帶抗癌基因的增殖性病毒載體等，研究結(jié)果發(fā)表在《科學(xué)》《自然醫(yī)學(xué)》《肝病學(xué)》《癌基因》等雜志上。

至今，吳孟超院士仍然致力于肝癌發(fā)病機(jī)制及肝癌醫(yī)治方略的研究當(dāng)中。

Introduction to Academician WU Mengchao

Wu Mengchao, academician of the Chinese Academy of Sciences, winner of the National Award of Science and Technology of China in 2005, a pioneer in Chinese liver cancer research, was an overseas Chinese born in Minqing County, Fujian Province, and returned from Malaysia in 1940. Prof. Wu graduated from Tongji University School of Medicine in 1949. He is grade-one professor and PhD supervisor of the Navy Medical University (formerly Second Military Medical University), and is known as the major founder of liver surgery in China and an outstanding scientist of medicine.

Prof. Wu proposed the anatomic idea of “five lobes and four segments”. To solve the challenging problem of hemorrhage in liver operations, he created the technique of “intermittent occlusion of porta hepatis in normothermic condition”. He set up a series of new strategies for correcting fatal disturbance of biochemical metabolism occurring perioperatively. He raised the concept of “two-stage operation”, which opened up a new approach to the treatment of late-stage liver cancer.

Prof. Wu has developed the current world’s medical center of hepatobiliary surgery, and has been leading a series of basic studies of the world up-to-date level, including biopathologic study on liver cancer. His team also developed two vaccines, that is cell fusion vaccine and bi-specific monoclonal antibody modified vaccine, and created proliferative virus vectors carrying anti-cancer gene. The results of these studies are published inScience,Nature Medicine, Hepatology, Oncogene, etc.

Today, academician Wu Mengchao remains active in clinic and basic research of liver cancer, developing effective therapeutic strategies and investigating mechanisms of hepatocarcinogenesis.

封面人物：中國(guó)科學(xué)院院士——吳孟超