廖俊豐
摘 要 目的:探討藍芩口服液聯(lián)合西藥治療反流性咽喉炎(LPRD)的臨床效果。方法:選取LPRD患者104例,隨機分為對照組和治療組各52例,對照組給予蘭索拉唑和多潘立酮治療,治療組在對照組的基礎(chǔ)上給予藍芩口服液治療,療程4周。對臨床療效進行評價。結(jié)果:治療前,兩組的RSI評分和RFS評分比較無顯著性差異。治療后,治療組的RSI評分和RFS評分明顯低于對照組;臨床總有效率明顯優(yōu)于對照組(P<0.05)。結(jié)論:采用藍芩口服液聯(lián)合蘭索拉唑、多潘立酮治療LPRD,可明顯改善患者反流癥狀和反流體征,提高臨床療效。
關(guān)鍵詞 藍芩口服液 蘭索拉唑 多潘立酮 反流性咽喉炎 臨床效果
中圖分類號:R286; R766.12 文獻標志碼:A 文章編號:1006-1533(2020)11-0035-03
Clinical effect of Lanqin oral liquid combined with western medicine in the treatment of laryngopharyngeal reflux disease
LIAO Junfeng
(Department of Otolaryngology, the Peoples Hospital of Qingxin District, Guangdong Qingyuan 511800, China)
ABSTRACT Objective: To explore the clinical effect of Lanqin oral liquid combined with western medicine in the treatment of laryngopharyngeal reflux disease (LPRD). Methods: One hundred and four patients with LPRD were randomly divided into a control group and a treatment group with 52 cases each. Both groups were treated with lansoprazole and domperidone and the treatment group was additionally treated with Lanqin oral liquid, which were lasted for 4 weeks, and their clinical effects were evaluated. Results: There were no significant differences between the two groups in the RSI score and RFs score before treatment. However, the RSI score and RFs score were significantly lower and the total clinical effective rates were significantly higher in the treatment group than the control group after treatment (P<0.05). Conclusion: Lanqin oral liquid combined with lansoprazole and domperidone for the treatment of LPRD can significantly improve the symptoms and signs of reflux and the clinical efficacy.
KEy WORDS Lanqin oral liquid; lansoprazole; domperidone; laryngopharyngeal reflux disease; clinical effect
反流性咽喉炎(laryngopharyngeal reflux disease, LPRD)是臨床上常見的一種疾病,普遍認為其病因與飲食有較大關(guān)系。經(jīng)常性的過饑過飽、進食辛辣刺激性食物、睡前2 h進食或宵夜等習(xí)慣,均是本病的常見誘因。本病的損傷病機主要有兩個方面:其一是返流的胃酸直接引起咽喉黏膜的損傷和不適;其二是胃和十二指腸的內(nèi)容物返流刺激遠端食管,引起迷走反射,導(dǎo)致咳嗽、清嗓以及食道上括約肌舒張,而使胃內(nèi)容物反流并導(dǎo)致咽喉損傷。其癥狀為:咽異物感或癔球感、聲嘶及發(fā)音困難、慢性干咳等。體征為:咽喉黏膜劈裂、潰瘍或肉芽腫,后聯(lián)合、聲帶充血水腫,嚴重的會出現(xiàn)刺激性咳嗽、嘔吐等[1]。而胃食管反流病患者其胃酸經(jīng)過食管反流到咽喉位置后對咽喉黏膜產(chǎn)生刺激,可導(dǎo)致慢性咽炎發(fā)生。相關(guān)研究顯示,胃食管反流病和慢性咽炎存在一定的聯(lián)系,并且二者會相互影響,從而導(dǎo)致LPRD[2]。
1 臨床資料
1.1 一般資料
選取2016年5月—2019年3月在清遠市清新區(qū)人民醫(yī)院治療的LPRD患者104例,所有患者經(jīng)電子喉鏡和胃鏡檢查確診為LPRD,診斷標準參考《咽喉反流性疾病診斷與專家共識》及其解讀中的標準[3]:反流癥狀指數(shù)量表評分(RSI)>13分和/或反流體征評分量表評分(RFS)>7分。將患者按隨機數(shù)字表法分為治療組和對照組,每組52例。其中治療組男21例,女31例;年齡24~65歲,平均年齡(45.7±10.3)歲;病程6個月~ 7年,平均病程(2.3±1.0)年。對照組男21例,女31例;年齡20~64歲,平均年齡(42.5±11.6)歲;病程7個月~6年,平均病程(2.2±1.1)年。兩組患者一般資料比較差異無統(tǒng)計學(xué)意義(P>0.05),具可比性。