張曉燕

摘要：目的 觀察老年高血壓在中醫(yī)治未病思想下應(yīng)用降壓藥物治療對腎損害的預(yù)防作用。方法? 選取2017年1月～2018年8月我院收治的老年高血壓患者92例，采用隨機(jī)數(shù)表法分為兩組，各46例。對照組單純予以降壓藥物干預(yù)，觀察組應(yīng)用降壓藥物+中醫(yī)未病思想干預(yù)。比較兩組血壓、腎功能[尿微量白蛋白（UmAlb）、肌酐清除率（Ccr）及尿β2-微球蛋白（Uβ2-MG）]。結(jié)果兩組干預(yù)2個月血壓水平均較治療前降低，且觀察組降幅大于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）;觀察組干預(yù)2個月UmAlb、Uβ2-MG低于對照組，Ccr高于對照組，差異有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論? 針對老年高血壓患者，應(yīng)用中醫(yī)治未病思想與降壓藥物進(jìn)行干預(yù)利于降低血壓水平，預(yù)防腎損害。

關(guān)鍵詞：老年高血壓;腎損害;中醫(yī)治未病思想;降壓藥

中圖分類號：R544.1? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?文獻(xiàn)標(biāo)識碼：A? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ?DOI：10.3969/j.issn.1006-1959.2019.06.053

文章編號：1006-1959（2019）06-0164-02

Abstract：Objective? To observe the preventive effect of antihypertensive drugs on renal damage in elderly patients with hypertension. Methods? A total of 92 elderly hypertensive patients admitted to our hospital from January 2017 to August 2018 were enrolled. The patients were divided into two groups， 46 cases each.The control group was treated with antihypertensive drugs alone， and the observation group was treated with antihypertensive drugs + traditional Chinese medicine to prevent ideological intervention. Blood pressure and renal function UmAlb， creatinine clearance （Ccr） and urinary β2-microglobulin （Uβ2-MG） were compared between the two groups. Results? The blood pressure levels of the two groups were lower than those before treatment， and the decrease in the observation group was greater than that in the control group，the difference was statistically significant （P<0.05）. In the observation group， the UmAlb and Uβ2-MG were lower than the control group for 2 months. Ccr was higher than the control group，the difference was statistically significant （P<0.05）. Conclusion? In the elderly patients with hypertension， the application of TCM treatment and antihypertensive drugs to prevent blood pressure levels and prevent renal damage.

Key words：Elderly hypertension;Kidney damage;Chinese medicine treatment and prevention thought; Antihypertensive drugs

高血壓前期人群屬于高血壓進(jìn)展的重點(diǎn)人群，特別是老年患者。相關(guān)研究指出，高血壓患者大多合并程度不一的腎損害，盡早進(jìn)行科學(xué)有效的干預(yù)，改善生活方式，調(diào)整日常飲食，可起到一定的預(yù)防作用[1，2]。中醫(yī)治未病思想來源于《黃帝內(nèi)經(jīng)》，主張未病先防，防患于未然，將其應(yīng)用于老年高血壓腎損害預(yù)防指導(dǎo)過程中，并結(jié)合降壓藥物進(jìn)行干預(yù)，可在一定程度上維護(hù)患者健康[3]。本研究探討了中醫(yī)治未病思想與降壓藥物聯(lián)合應(yīng)用預(yù)防老年高血壓患者腎損害的療效，現(xiàn)報道如下。

1資料與方法

1.1 一般資料? 選取2017年1月～2018年8月成都中醫(yī)藥大學(xué)第三附屬醫(yī)院收治的老年高血壓患者92例，采用隨機(jī)數(shù)表法分為兩組，各46例。本研究經(jīng)我院醫(yī)學(xué)倫理委員會批準(zhǔn)，患者及其家屬對本研究均知情，并簽署知情同意書。觀察組男25例，女21例;年齡60～85歲，平均年齡（73.34±2.57）歲。對照組男24例，女22例;年齡60～87歲，平均年齡（73.43±2.62）歲。比較兩組一般資料，差異無統(tǒng)計學(xué)意義（P>0.05），具有可比較性。