劉梅
[摘要] 目的 研究厄貝沙坦聯(lián)合胺碘酮治療心衰并發(fā)室性心律失常的臨床效果。 方法 隨機(jī)選取2015年10月—2016年10月該院心衰并發(fā)室性心律失?;颊?0例,隨機(jī)分2組,每組40例,對照組胺碘酮片,觀察組再給予厄貝沙坦,對比兩組患者的室性心律失常、心功能以及治療后的HR、 LVEF情況。結(jié)果 觀察組心衰并發(fā)室性心律失?;颊咝墓δ艿目傆行蕿?2.50%,室性心律失??刂朴行蕿?7.50%,治療效果明顯優(yōu)于對照組,差異有統(tǒng)計學(xué)意義(P<0.05)。觀察組治療后HR情況為(72.65±4.32)次/min,LVEF情況為(50.66±6.49)%,觀察組心衰并發(fā)室性心律失?;颊叩腍R、LVEF情況明顯優(yōu)于對照組,差異有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論 厄貝沙坦聯(lián)合胺碘酮治療的安全性高,在臨床治療效果中顯著,適用于心衰并發(fā)室性心律失常的治療。
[關(guān)鍵詞] 心衰并發(fā)室性心律失常;厄貝沙坦;胺碘酮
[中圖分類號] R541.6 [文獻(xiàn)標(biāo)識碼] A [文章編號] 1674-0742(2017)02(b)-0125-03
[Abstract] Objective To research the clinical effect of irbesartan and amiodarone in treatment of heart failure and ventricular arrhythmias. Methods Random selection 80 cases of patients with heart failure and ventricular arrhythmias admitted and treated in our hospital from October 2015 to October 2016 were selected and randomly divided into two groups with 40 cases in each, the control group were treated with amiodarone tablets, while the observation group were treated with irbesartan, and the ventricular arrhythmias, heart function and HR and LVEF after treatment were compared between the two groups. Results The total effective rate of heart function of patients with heart failure and ventricular arrhythmias in the observation group was obviously better than that in the control group(92.50% vs 87.50%), and the difference had statistical significance(P<0.05), and the HR and LVEF after treatment in the observation group[(72.65±4.32)times/min,(50.66±6.49)%] were obviously better than those in the control group, and the differences had statistical significance(P<0.05). Conclusion The safety of irbesartan and amiodarone in treatment of heart failure and ventricular arrhythmias is high, and the clinical treatment effect is obvious, which is suitable for the treatment of heart failure and ventricular arrhythmias.
[Key words] Heart failure and ventricular arrhythmias; Irbesartan; Amiodarone
慢性心力衰竭是多種心臟病發(fā)展的最終階段,易并發(fā)室心律失常,由于疾病的危險性,如果不及時治療,會發(fā)生血液流變學(xué)障礙或更進(jìn)一步發(fā)展為室顫、持續(xù)性室速,嚴(yán)重者則引發(fā)生命危險[1]。該院將隨機(jī)選取2015年10月—2016年10月該院心衰并發(fā)室性心律失常患者80例,分析厄貝沙坦聯(lián)合胺碘酮治療心衰并發(fā)室性心律失常的臨床效果,獲得了可觀的效果,現(xiàn)報道如下。
1 資料與方法
1.1 一般資料
隨機(jī)選取在該院治療心衰并發(fā)室性心律失常的患者80例作為研究對象,隨機(jī)分配為2組,觀察組和對照組各40例。觀察組心衰并發(fā)室性心律失常的患者中,男29例,女11例,年齡46~85歲,平均年齡為(65.23±5.22)歲,病理類型:冠心病占有12例,高血壓性心臟病的患者8例,風(fēng)濕性心臟病15例患者,擴(kuò)張性心臟病的例數(shù)為5例。對照組患者當(dāng)中,男28例,女12例,年齡為45~86歲,平均年齡(66.05±5.18)歲,上述病理類型分別是:12例,10例,14例;4例。2組心衰并發(fā)室性心律失常患者各項上述一般資料差異無統(tǒng)計學(xué)意義(P>0.05)。
1.2 方法
對照組進(jìn)行胺碘酮片治療。服用胺碘酮片(國藥準(zhǔn)字號H19993347)0.2 g,口服3次/d;1周后改為0.2 g胺碘酮片,口服2次/d;兩個星期后改為0.2 g口服,1次/d。觀察組在上述基礎(chǔ)上,再實施厄貝沙坦(國藥準(zhǔn)字號H20130002),口服的方式,按照服用150 mg/d劑量的頻率治療1個星期,之后劑量降為75 mg/d,再根據(jù)其病情給予心衰并發(fā)室性心律失?;颊邷p量或維持。