陳 珊 程 熠 劉 全 (吉林大學白求恩第一醫(yī)院心血管診治中心，吉林 長春 3002)

1 SOD的生物學效應

2 SOD在血管性疾病中的作用

3 SOD與血管重構

4 未來方向

1 Go YM，Jones DP.Cysteine/cystine redox signaling in cardiovascular disease〔J〕.Free Radic Biol Med，2011;50(4):495-509.

2 Lassegue B，Griendling KK.NADPH oxidases:functions and pathologies in the vasculature〔J〕.Arterioscler Thromb Vasc Biol，2010;30:653-61.

3 Ushio-Fukai M.Compartmentalization of redox signaling through NADPH oxidase-derived ROS〔J〕.Antioxid Redox Signal，2009;11:1289-99.

4 Guzik TJ，Harrison DG.Vascular NADPH oxidases as drug targets for novel antioxidant strategies〔J〕.Drug Discov Today，2006;11:524-33.

5 Madamanchi NR，Runge MS.Mitochondrial dysfunction in atherosclerosis〔J〕.Circ Res，2007;100:460-73.

6 Rhee SG.Cell signaling.H2O2，a necessary evil for cell signaling〔J〕.Science，2006;312:1882-3.

7 Tonks NK.Redox redux:revisiting PTPs and the control of cell signaling〔J〕.Cell，2005;121:667-70.

8 Ushio-Fukai M.Localizing NADPH oxidase-derived ROS〔J〕.Sci STKE，2006:re8，2006.

9 Li Q，Harraz MM，Zhou W，et al.Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes〔J〕.Mol Cell Biol，2006;26:140-54.

10 Bienert GP，Moller AL，Kristiansen KA，et al.Specific aquaporins facilitate the diffusion of hydrogen peroxide across membranes〔J〕.J Biol Chem，2007;282:1183-92.

11 Hawkins BJ，Madesh M，Kirkpatrick CJ，et al.Superoxide flux in endothelial cells via the chloride channel-3 mediates intracellular signaling〔J〕.Mol Biol Cell，2007;18:2002-12.

12 Miller FJ Jr，F(xiàn)ilali M，Huss GJ，et al.Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3〔J〕.Circ Res，2007;101:663-71.

13 Mumbengegwi DR，Li Q，Li C，et al.Evidence for a superoxide permeability pathway in endosomal membranes〔J〕.Mol Cell Biol，2008;28:3700-12.

14 Alvarez B，Demicheli V，Duran R，et al.Inactivation of human Cu，Zn superoxide dismutase by peroxynitrite and formation of histidinyl radical〔J〕.Free Radic Biol Med，2004;37:813-22.

15 Ischiropoulos H，Zhu L，Chen J，et al.Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase〔J〕.Arch Biochem Biophys，1992;298:431-7.

16 MacMillan-Crow LA，Crow JP，Kerby JD，et al.Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts〔J〕.Proc Natl Acad Sci U S A，1996;93:11853-8.

17 Leite PF，Danilovic A，Moriel P，et al.Sustained decrease in superoxide dismutase activity underlies constrictive remodeling after balloon injury in rabbits〔J〕.Arterioscler Thromb Vasc Biol，2003;23:2197-202.

18 Hink HU，Santanam N，Dikalov S，et al.Peroxidase properties of extracellular superoxide dismutase:role of uric acid in modulating in vivo activity〔J〕.Arterioscler Thromb Vasc Biol，2002;22:1402-8.

19 Balaban RS，Nemoto S，F(xiàn)inkel T.Mitochondria，oxidants，and aging〔J〕.Cell，2005;120:483-95.

20 Murphy MP.How mitochondria produce reactive oxygen species〔J〕.Biochem J，2009;417:1-13.

21 Zorov DB，Juhaszova M，Sollott SJ.Mitochondrial ROS-induced ROS release:an update and review〔J〕.Biochim Biophys Acta，2006;1757:509-17.

22 Ghafourifar P，Richter C.Nitric oxide synthase activity in mitochondria〔J〕.FEBS Lett，1997;418:291-6.

23 Giulivi C，Poderoso JJ，Boveris A.Production of nitric oxide by mitochondria〔J〕.J Biol Chem，1998;273:11038-43.

24 Brown GC，Cooper CE.Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase〔J〕.FEBS Lett，1994;356:295-8.

25 Cleeter MW，Cooper JM，Darley-Usmar VM，et al.Reversible inhibition of cytochrome c oxidase，the terminal enzyme of the mitochondrial respiratory chain，by nitric oxide.Implications for neurodegenerative diseases〔J〕.FEBS Lett，1994;345:50-4.

26 Stocker R，Keaney JF Jr.Role of oxidative modifications in atherosclerosis〔J〕.Physiol Rev，2004;84:1381-478.

27 Nelson SK，Bose SK，McCord JM.The toxicity of high dose superoxide dismutase suggests that superoxide can both initiate and terminate lipid peroxidation in the reperfused heart〔J〕.Free Radic Biol Med，1994;16:195-200.

28 Cathcart MK，McNally AK，Morel DW，et al.Superoxide anion participation in human monocytemediated oxidation of low-density lipoprotein and conversion of low-density lipoprotein to a cytotoxin〔J〕.J Immunol，1989;142:1963-9.

29 White CR，Brock TA，Chang LY，et al.Superoxide and peroxynitrite in atherosclerosis〔J〕.Proc Natl Acad Sci U S A，1994;91:1044-8.

30 Lehr HA，Becker M，Marklund SL，et al.Superoxide-dependent stimulation of leukocyte adhesion by oxidatively modified LDL in vivo〔J〕.Arterioscler Thromb，1992;12:824-9.

31 Madamanchi NR，Moon SK，Hakim ZS，et al.Differential activation of mitogenic signaling pathways in aortic smooth muscle cells deficient in superoxide dismutase isoforms〔J〕.Arterioscler Thromb Vasc Biol，2005;25:950-6.

32 Papaharalambus CA，Griendling KK.Basic mechanisms of oxidative stress and reactive oxygen species in cardiovascular injury〔J〕.Trends Cardiovasc Med，2007;17:48-54.

33 Makino A，Skelton MM，Zou AP，et al.Increased renal medullary oxidative stress produces hypertension〔J〕.Hypertension，2002;39:667-72.

34 Kopkan L，Castillo A，Navar LG，et al.Enhanced superoxide generation modulates renal function in ANG Ⅱ-induced hypertensive rats〔J〕.Am J Physiol Renal Physiol，2006;290:F80-6.

35 Papaharalambus CA，Griendling KK.Basic mechanisms of oxidative stress and reactive oxygen species in cardiovascular injury〔J〕.Trends Cardiovasc Med，2007;17:48-54.

36 Brasen JH，Leppanen O，Inkala M，et al.Extracellular superoxide dismutase accelerates endothelial recovery and inhibits instent restenosis in stented atherosclerotic Watanabe heritable hyperlipidemic rabbit aorta〔J〕.J Am Coll Cardiol，2007;50:2249-53.

37 Laukkanen MO，Kivela A，Rissanen T，et al.Adenovirus-mediated extracellular superoxide dismutase gene therapy reduces neointima formation in balloondenuded rabbit aorta〔J〕.Circulation，2002;106:1999-2003.

38 Ozumi K，Tasaki H，Takatsu H，et al.Extracellular superoxide SOD and vascular disease 1603 dismutase overexpression reduces cuff-induced arterial neointimal formation〔J〕.Atherosclerosis，2005;181:55-62.

39 Leite PF，Danilovic A，Moriel P，et al.Sustained decrease in superoxide dismutase activity underlies constrictive remodeling after balloon injury in rabbits〔J〕.Arterioscler Thromb Vasc Biol，2003;23:2197-202.

40 Agrawal RS，Muangman S，Layne MD，et al.Preemptive gene therapy using recombinant adeno-associated virus delivery of extracellular superoxide dismutase protects heart against ischemic reperfusion injury，improves ventricular function and prolongs survival〔J〕.Gene Ther，2004;11:962-9.

41 Vozenin-Brotons MC，Sivan V，Gault N，et al.Antifibrotic action of Cu/Zn SOD is mediated by TGF-beta1 repression and phenotypic reversion of myofibroblasts〔J〕.Free Radic Biol Med，2001;30:30-42.

42 Salvemini D，Riley DP，Cuzzocrea S.SOD mimetics are coming of age〔J〕.Nat Rev Drug Discov，2002;1:367-74.

43 Heistad DD.Gene therapy for vascular disease〔J〕.Vasc Pharmacol，2006;45:331-3.

44 Muzykantov VR.Targeting of superoxide dismutase and catalase to vascular endothelium〔J〕.J Control Rel，2001;71:1-21.