阿拉木斯

[關(guān)鍵詞] 艾司西酞普蘭;抑郁;酒精依賴;生活質(zhì)量

[中圖分類號(hào)] R749.41? ? ? ? ? [文獻(xiàn)標(biāo)識(shí)碼] B? ? ? ? ? [文章編號(hào)] 1673-9701（2021）20-0101-03

Effect of escitalopram in treatment of alcohol dependence with depression and its effect on quality of life of patients

A Lamusi

Addiction Medicine Center，Inner Mongolia Mental Health Center， Huhehot? ? 010010， China

[Abstract] Objective To explore and analyze the effect of escitalopram in treatment of alcohol dependence with depression and its effect on quality of life of patients. Methods Research subjects were selected from January 2019 to April 2020， and all the 72 patients with depression and alcohol dependence were admitted to our hospital for treatment. According to the random number table， 36 patients in the conventional group were treated with conventional alcohol detoxication therapy， and 36 patients in the study group were treated with escitalopram in addition to the conventional group. The changes of depression mood， sleep quality， alcohol dependence and social dysfunction， quality of life and the rates of adverse reactions were statistically analyzed between the routine group and the study group. Results After treatment， the HAMD score， PQI score， alcohol dependence score and social function deficit score in the study group were lower than those in the control group， and the GQOL-74 scores in mental health， material life， physical health and social function were higher than those in the control group， and the differences were statistically significant（P<0.05）. No significant difference was observed in the total rate of adverse reaction rate between the conventional group and the study group（P>0.05）. Conclusion Escitalopram can effectively relieve depression， improve sleep quality， reduce alcohol dependence， improve social function of patients， and effectively improve the quality of life of patients with high drug safety， which is worthy of promotion.

[Key words] Escitalopram; Depression; Alcohol dependence; Quality of life

酒精依賴的出現(xiàn)通常與患者長(zhǎng)期飲酒有關(guān)，飲酒過(guò)量、持續(xù)飲酒時(shí)間過(guò)長(zhǎng)會(huì)使得患者難以控制飲酒行為，無(wú)法對(duì)自身行為進(jìn)行約束，并最終致使酒精依賴發(fā)生[1-2]。酒精依賴癥狀不僅會(huì)對(duì)患者生理功能產(chǎn)生負(fù)面影響，還會(huì)在患者心理層面構(gòu)成情緒干擾，患者容易因此出現(xiàn)焦慮、煩躁情緒[3-4]。據(jù)相關(guān)研究統(tǒng)計(jì)結(jié)果數(shù)據(jù)顯示，酒精依賴患者更容易出現(xiàn)精神障礙癥狀，其發(fā)生率為正常人群的2～4倍，其中同時(shí)伴發(fā)抑郁癥狀的酒精依賴患者群體的總占比大約為10%[5-6]。抑郁情緒的出現(xiàn)會(huì)導(dǎo)致酒精依賴患者睡眠質(zhì)量降低，對(duì)患者的戒酒效果產(chǎn)生嚴(yán)重負(fù)面影響[7]。本研究旨在探討分析艾司西酞普蘭治療伴抑郁酒精依賴的效果及對(duì)患者生活質(zhì)量的影響，現(xiàn)報(bào)道如下。

1 資料與方法

1.1一般資料

選取2019年1月至2020年4月于我院就診治療的72例伴抑郁酒精依賴患者。納入標(biāo)準(zhǔn)：患者病情符合伴抑郁酒精依賴診斷標(biāo)準(zhǔn)[8]。排除標(biāo)準(zhǔn)[9]：認(rèn)知異常者、溝通困難者、對(duì)研究藥物過(guò)敏者。采用隨機(jī)數(shù)字表法分為兩組，每組各36例。常規(guī)組患者采用常規(guī)酒精脫依賴治療，研究組患者在常規(guī)組基礎(chǔ)上應(yīng)用艾司西酞普蘭治療。其中所有患者均為男性，常規(guī)組年齡25～53歲，平均（33.69±6.38）歲，飲酒時(shí)間6～18年，平均（10.47±3.14）年。研究組年齡26～54歲，平均（34.13±6.17）歲，飲酒時(shí)間6～18年，平均（10.56±3.22）年。兩組患者臨床資料比較，差異無(wú)統(tǒng)計(jì)學(xué)意義（P>0.05），具有可比性。該研究經(jīng)醫(yī)院醫(yī)學(xué)倫理標(biāo)準(zhǔn)委員會(huì)批準(zhǔn)，所有研究對(duì)象均知情且同意參與。