李灼非　鄧興明　李粵

【摘要】 目的：觀察血清及癌組織VEGF（VEGF-A、VEGF-C）及其受體（VEGFR-3）在結(jié)腸癌患者中的變化。方法：選取2013年3月-2018年5月本院診治的結(jié)腸癌患者100例為觀察組，同期結(jié)腸良性病變患者100例為對照組。檢測與比較兩組血清VEGF及其受體水平、組織VEGF及其受體陽性率，并比較其在觀察組不同分期與分化程度中的差異。結(jié)果：觀察組血清VEGF及其受體水平、組織VEGF及其受體陽性率均高于對照組，且不同分期與分化程度結(jié)腸癌患者間血清VEGF及其受體水平、組織VEGF及其受體陽性率比較，差異均有統(tǒng)計學(xué)意義（P<0.05）。結(jié)論：血清及癌組織VEGF及其受體在結(jié)腸癌患者中呈現(xiàn)異常表達，且不同分期與分化程度結(jié)腸癌患者的表達也存在一定差異，血清及癌組織VEGF及其受體表達可能與結(jié)腸癌疾病進展、臨床分期和病理分化程度密切相關(guān)，在結(jié)腸癌患者中具有較高的臨床檢測價值。

【關(guān)鍵詞】 血清; 癌組織; VEGF; 結(jié)腸癌

【Abstract】 Objective：To observe the change situation of serum and cancer tissue VEGF（VEGF-A，VEGF-C）and its receptors（VEGFR-3）of patients with colon cancer.Method：A total of 100 patients with colon cancer diagnosed and treated in our hospital from March 2013 to May 2018 were selected as observation group，and 100 patients with benign colon lesions in the same period were selected as control group.The serum levels of VEGF and its receptor，the positive rate of tissue VEGF and its receptor were detected and compared between two groups，and the differences in different stages and differentiation degree of observation group were compared.Result：The serum levels of VEGF and its receptor，the positive rates of tissue VEGF and its receptor in observation group were higher than those of control group，and the serum levels of VEGF and its receptor，the positive rates of tissue VEGF and its receptor in patients with colon cancer of different stages and differentiation degrees were compared，the differences were statistically significant（P<0.05）.Conclusion：The serum and cancer tissue VEGF and its receptors of patients with colon cancer show abnormal expression，and the expression of patients with different stages and differentiation degree of colon cancer had certain differences too，the expression of serum and cancer tissue VEGF and its receptors may have close relationship to the disease rogression，clinical stage and pathological differentiation of colon cancer，so they have higher detection value for the patients with colon cancer.

【Key words】 Serum; Cancer tissue; VEGF; Colon cancer

First-authors address：Peking University Shenzhen Hospital，Shenzhen 518000，China

doi：10.3969/j.issn.1674-4985.2019.04.012

結(jié)腸癌是消化系統(tǒng)常見惡性腫瘤之一，患者的早期缺乏特異性表現(xiàn)，中晚期出現(xiàn)消化系統(tǒng)方面的癥狀體征，對患者的生存狀態(tài)造成極大的不良影響。而早期有效的診斷與治療是患者預(yù)后改善的必要基礎(chǔ)前提[1]。臨床中與結(jié)腸癌相關(guān)的研究多見，而VEGF作為在各類惡性腫瘤中研究較多的指標(biāo)，其相關(guān)受體在結(jié)腸癌中的研究也可見[2-3]，但是對于其表達情況的細致變化及確切的檢測價值探究十分匱乏。本研究就血清及組織VEGF及其受體在結(jié)腸癌患者中的變化情況進行觀察與探究，現(xiàn)報道如下。

1 資料與方法

1.1 一般資料 選取2013年3月-2018年5月本院診治的結(jié)腸癌患者100例為觀察組，同期結(jié)腸良性病變患者100例為對照組。納入標(biāo)準(zhǔn)：年齡20～75歲;就診前未接受相關(guān)治療者。排除標(biāo)準(zhǔn)：合并其他消化系統(tǒng)疾病;合并心腦肺腎等慢性疾病;合并其他腫瘤;精神病患者;癡呆及其他認(rèn)知情況的認(rèn)知障礙者。該研究已經(jīng)倫理學(xué)委員會批準(zhǔn)，并提供相關(guān)證明，患者知情同意并簽署知情同意書。