Qiang Sun,Chun-Lin Zhang,Zhao-Hui Liu

Abstract

Key words: Hypopharynx tumor;Sclerotic lipoma;Plasma;Case report

INTRODUCTION

Up to date,less than 100 cases of pedunculated lipoma of hypopharynx have been reported[1].Most of them are fibrous lipoma,as shown in histopathology.We here report a rare case of sclerotic lipoma.The first case of pedunculated lipoma of hypopharynx was reported by Colchester in 1952 in a patient who died of asphyxiation due to sucking in the lipoma[2].Hypopharyngeal pedunculated lipoma grows slowly and generally has no obvious symptoms.When respiratory aspiration occurs,it can block the upper airway and kill the patient easily.The key to treatment is timely surgical resection.

CASE PRESENTATION

Chief complaints

An 86-year-old female patient presented to our department with a long pendulous mass protruding from her mouth (Figure 1).

History of present illness

The patient coughed up the mass in the morning and had no dyspnea or dysphagia until entering the hospital.

History of past illness

She had no history of surgery,chronic diseases,or allergies.

Personal and family history

She gave birth to two daughters,bothviavaginal delivery,and she had no history of smoking or drinking.There was no similar history in the family.

Physical examination upon admission

A thick pendulous mobile mass was hanging outside the mouth,and the root was derived from the back wall of the hypopharynx.The surface of the mass was smooth and hyperemic.Other tests were normal.

Laboratory examinations

No abnormality was found in routine blood tests,biochemical tests,or electrocardiogram.

Imaging examinations

Postoperative chest computed tomography showed widened esophagus.

FINAL DIAGNOSIS

Sclerotic lipoma in the hypopharynx.

TREATMENT

The lipoma was removed with plasma radiofrequency at low temperature under general anesthesia (Figures 2 and 3).The postoperative pathological results were fibrosclerosing lipoma,and immunohistochemistry was positive for vimentin,S100,and CD34 (Figure 4).

OUTCOME AND FOLLOW-UP

Electronic laryngoscopy showed good white membrane growth in the operative area 4 d after surgery.The patient had no discomfort in the hypopharynx.

DISCUSSION

Lipoma in the pharynx is relatively rare[3],and accounts for 0.6% of the benign tumors of the pharynx[4].Lipoma is associated with endocrine factors,infection,chronic disease,infection,and heredity[5].Lipoma of the hypopharynx grows slowly and generally has no obvious symptoms.Only a few patients may present with dysphagia,reflux foreign body sensation,or cough[6],but sudden airway blockage may occur[7].Most of the patients do not visit the emergency department for treatment until a rapidly increased abdominal pressure appeared,such as cough,and the tumor came out of the mouth.Our patient,who had no special sensation for a long time,was admitted to the emergency department of our hospital after coughing out the mass.To our surprise,the large tumor did not cause swallowing and breathing difficulties.The reason may be that the narrow peduncle of the lipoma can pass through the pharyngoesophageal sphincter,and the tumor body grows slowly in the esophagus,resulting in expansion of the esophagus.The slow process makes the body adaptable to the tumor in this patient.Enlarged esophagus was seen on postoperative chest computed tomography (Figure 5).

The most serious complication of hypopharyngeal lipoma is asphyxia death.Once the tumor is diagnosed,the patient is likely to suffer from airway obstruction within a short period of time,which should be monitored closely.The first reported patient with hypopharyngeal lipoma died of asphyxia due to aspiration[4].Therefore,timely surgical treatment is necessary.Currently,there are a variety of surgical approaches.Some authors recommend endoscopic resection for small lesions,while for tumors larger than 2 cm,open surgery is preferred[7].Others suggest that endoscopic surgery has advantages of quick recovery and less trauma to patients,and endoscopic resection may also be used for larger masses[5,8].In contrast to previous reports of similar cases,we used the plasma knife as the resection tool.The plasma knife has a good hemostasis function during the operation,keeping the field clear,and low temperature can minimize the damage to the surrounding tissues.Therefore,we recommend the plasma knife as a tool for tumor resection in similar cases.Specific tumor resection should refer to the size,location,and scope of the tumor as well as the experience of the surgeon.Considering that our patient was old and complicated with systemic diseases such as heart disease,we selected the plasma resection combined with endoscopic resection for tumor exposure by mouth gag.After the surgery,the patient was transferred to the ordinary ward and able to take a fluid diet.The patient and her family were satisfied with the treatment effect.

Figure2 Root of lipoma was located in the posterior wall of the hypopharynx.

In this case,the pathologic type is sclerotic lipoma,which is a variant type in the pathological classification of lipoma and was first reported by Zelgeret al[9]in 1997.It is characterized by spindle cells or fibroblast-like cells and dense intercellular matrix microscopically,in which fat cells are distributed[10].The structure is similar to fibroma,except that there are different numbers of fat cells in the background of fibrosclerosis.To date,less than 30 cases of sclerotic lipoma have been reported worldwide[11],most of which occur in the limbs and scalp,and no literature has reported one on pharynx.

CONCLUSION

We report a rare case of hypopharyngeal pedunculated lipoma,and the pathological type is sclerotic lipoma.We recommend timely resection to prevent airway obstruction and death.Plasma resection is a good option during surgery.

Figure3 Lipoma in contrast with a 20 mL syringe.

Figure5 Postoperative chest computed tomography shows enlarged esophagus.