Reviews

Deciphering nucleic acid modifications by chemical derivatization-mass spectrometry analysis

Meng-Dan Lan, Bi-Feng Yuan, Yu-Qi Feng

Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry, Wuhan University, Wuhan 430072, China

Chemical derivatization in combination with mass spectrometry (MS) analysis is a promising strategy for the sensitive and effective analysis of nucleic acid modifications. In this review, we summarize the recent advances for deciphering modifications in DNA and RNA by chemical derivatization-MS analysis.

Chinese Chemical Letters 30 (2019) 1

Mechanochemistry in cancer cell metastasis

Di Zhanga,b, Feng Fenga,b, Ruping Liuc, Wenjia Zhuc, Li Yaoa,b

aState Key Laboratory for Structural Chemistry of Unstable and Stable Species, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Science, Beijing 100190, China

bUniversity of Chinese Academy of Sciences, Beijing 100049, China

cBeijing Institute of Graphic Communication, Beijing 102600, China

In this review, we introduced the mechanical factors in cancer cell metastasis, intracellular mechanical sensors and methods to measure the mechanical forces of tumor cells for evaluating the mechanochemistry in cancer metastasis.

Chinese Chemical Letters 30 (2019) 7

Selectively transform lignin into value-added chem icals

Qingqing Meia, Xiaojun Shena,b, Huizhen Liua,b, Buxing Hana,b

aBeijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Colloid and Interface and Thermodynamics, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

bSchool of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China

Selective transformation of lignin into value-added chemicals is of strategic signifi cance. Phenols, aldehydes,carboxylic acids, alkanes and arenes can be harvested from lignin with high selectivity under appropriate reaction condition.

Chinese Chemical Letters 30 (2019) 15

Embedding pyridine units in acceptors to construct donor-acceptor conjugated polymers

Zi-Yuan Wang, Jie-Yu Wang, Jian Pei

Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Key Laboratory of Polymer Chemistry and Physics of Ministry of Education,Center for Soft Matter Science and Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

Embedding pyridine units into donor-acceptor (D-A) conjugated polymer backbones results in lowered lowest unoccupied molecular orbitals (LUMOs) and improved coplanarity of polymer backbones by the non-bonding interactions, leading to high-performance semiconducting polymers.

Chinese Chemical Letters 30 (2019) 25

Artificial light-harvesting systems fabricated by supramolecular host–guest interactions

Tangxin Xiaoa, Weiwei Zhonga, Ling Zhoua, Lixiang Xua, Xiao-Qiang Suna,Robert B.P.Elmesb, Xiao-Yu Huc, Leyong Wanga,c

aSchool of Petrochemical Engineering, Advanced Catalysis and Green Manufacturing Collaborative Innovation Center, Changzhou University, Changzhou 213164, China

bDepartment ofChemistry, Maynooth University, National University of Ireland, Maynooth, Ireland

cKey Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering,Nanjing University, Nanjing 210023, China

Recent progress on artificial light-harvesting systems fabricated by supramolecular host–guest interaction was summarized.

Chinese Chemical Letters 30 (2019) 31

Water-soluble supramolecular polymers constructed by macrocycle-based host-guest interactions

Yanmei Chena,b, Siyu Sunb, Dou Lub, Yujun Shia,b, Yong YaobaSchool of Environmental and Chemical Engineering, Jiangsu University of Science and Technology,Zhenjiang 212003, China

bCollege of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China

Water soluble supramolecular polymers are especially important due to their superior biocompatibility and environmental adaptation, which determined they have w ide applications in various areas, such as drug delivery, self-healing, shape memory. On the other hand, macrocyclic compounds are the most used building blocks in the preparation of supramolecular polymers. Macrocycle-based supramolecular polymers, which introduce the host-guest interaction in the system, endow these polymers with interesting and smart physicalchemical properties. In this review, we summarized recent studies about supramolecular polymers in aqueous solution based on macrocyclic compounds.

Chinese Chemical Letters 30 (2019) 37

Communications

Chartrenoline, a novel alkaloid isolated from a marine Streptomyces chartreusis NA02069

Chengli Liu, Chenglong Yang, Yingjie Zeng, Jing Shi, Lingyu Li, Wei Li, Ruihua Jiao,Renxiang Tan, Huiming Ge

State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecues, School of Life Sciences, Nanjing University, Nanjing 210023, China

A novel alkaloid featuring a unique tetracyclic ring system was isolated from a marine actinobacterium.

Chinese Chemical Letters 30 (2019) 44

Diterpenoids from the aerial parts of Leonurus macranthus

Yunfang Zhao, Zheng Huang, Jing Sun, Daoran Pang, Xiaonan Chen, Huina Yao, Zhixiang Zhu, Jiao Zheng, Pengfei Tu, Jun Li

Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica,Beijing University of Chinese Medicine, Beijing 100029, China

One cis clerodane-type (1) and three highly oxygenated labdane-type diterpenes (2–4) were isolated from the aerial parts of Leonurus macranthus. Compound 1 represents the fi rst example of cis clerodane-type diterpene in the plants of Leonurus genus.

Chinese Chemical Letters 30 (2019) 47

Dimericbiscognienynes B and C: New diisoprenyl-cyclohexenetype meroterpenoid dimers from Biscogniauxia sp.

Huan Zhaoa,b, Meizhi Wangc, Guodong Chena, Dan Hua, Enqing Lia, Yibo Quc, Libing Zhouc,Liangdong Guod, Xinsheng Yaoa, Hao Gaoa

aInstitute of Traditional Chinese Medicine and Natural Products, College of Pharmacy / Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University,Guangzhou 510632, China

bCollege of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China

cGuangdong-Hongkong-Macau Institute of CNS Regeneration, Joint International Research Laboratory of CNS Regeneration, Jinan University, Guangzhou 510632, China

dState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190,China

Till now, only three diisoprenyl-cyclohexene/ane-type meroterpenoid dimers have been identified.

The isolation of two new diisoprenyl-cyclohexene-type meroterpenoid dimers (dimericbiscognienynes B and C)from Biscogniauxia sp. 71-10-1-1 added new members to this family.

Chinese Chemical Letters 30 (2019) 51

A lysosomal targeting fluorescent probe and its zinc imaging in SH-SY5Y human neuroblastoma cells

Houna Duana, Yu Dinga, Chusen Huangb, Weiping Zhua, Rui Wangc, Yufang Xua

aState Key Laboratory of Bioreactor Engineerring, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

bThe Education Ministry Key Laboratory of Resource Chemistry and Shanghai Key Laboratory of Rare Earth Functional Materials, Department of Chemistry, College of Life and Environmental Sciences, Shanghai Normal University, Shanghai 200234, China

cShanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

A fluorescent probe based PET mechanism was designed, and the probe could image endogenous release of Zn2+upon H2O2stimulation in SH-SY5Y cells.

Chinese Chemical Letters 30 (2019) 55

G-quadruplex-assisted enzyme strand recycling for amplified label-free fluorescent detection of UO22+

Paijin Zhua, Yiying Zhanga, Shuxia Xub, Xinfeng Zhanga

aCollege of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu 610059, China

bCollege of Environment and Ecology, Chengdu University of Technology, Chengdu 610059, China

A G-quadruplex-assisted enzyme strand recycling strategy was developed for amplified label-free fluorescent detection of uranyl ion (UO22+).

Chinese Chemical Letters 30 (2019) 58

A specific and selective chemiluminescent probe for Pd 2+detection

Yuqi Gaoa, Yuxing Lina, Tingting Liua, Xiaomeng Zhanga, Feng Xua, Pan Liua, Lupei Dua,Minyong Lia,b

aDepartment of Medicinal Chemistry, Key Laboratory of Chemical Biology (MOE), School of Pharmacy,Shandong University, Ji’nan 250012, China

bState Key Laboratory of Microbial Technology, Shandong University, Ji’nan 250100, China

A modified 1,2-dioxetane is reported as a chemiluminescent imaging (CLI) approach for monitoring palladium(II).

Chinese Chemical Letters 30 (2019) 63

Intracellular effects of prodrug-like wortmannin probes

Shasha Yinga, Shubo Dub, Jia Donga, Bi Xuan Ngb, Chengw u Zhangc, Lin Lic, Jingyan Gea,Qing Zhua

aKey Laboratory of Bioorganic Synthesis of Zhejiang Province, College of Biotechnology and Bioengineering,Zhejiang University of Technology, Hangzhou 310014, China

bDepartment of Chemistry, National University of Singapore, Singapore 117543, Singapore

cKey Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech),Nanjing 211816, China

A small library of w ortmannin based probes was synthesized by installing a clickable handle at C11 site for bioconjugation, and secondary amine and biotin moiety at C20 site to achieve self-activation and cancer target,respectively, to facilitate the analysis of their intracellular effects.

C hinese Chemical Letters 30 (2019) 67

Novel strategy of constructing fluorescent probe for MAO-B via cascade reaction and its application in imaging MAO-B in human astrocyte

Huihuan Qin, Lingling Li, Kun Li, Xiaoqi Yu

Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China

A novel strategy was developed to detect MAO-B and image MAO-B in human astrocyte by constructing coumarin via cascade reaction and intramolecular cyclization.

Chinese Chemical Letters 30 (2019) 71

A water-stable lanthanide-coordination polymer with free Lew is site for fluorescent sensing of Fe3+

Wenhe Wanga, Qiang Gaob, Xiaoyu Lib, Jianhong Wanga, Chaopeng Wangb, Yinghui Zhangb,Xianhe Bua,b

aDepartment of Chemistry, Collaborative Innovation Center of Chemical Science and Engineering(Tianjin), Nankai University, Tianjin 300071, China

bSchool of Materials Science and Engineering, TKL of Metal- and Molecule-Based Material Chemistry,Nankai University, Tianjin 300350, China

A Tb3+based coordination polymer (NKU-115) with free N sites was successfully constructed, featuring strong green light emission and selective quenching response tow ard Fe3+in aqueous solution.

Chinese Chemical Letters 30 (2019) 75

Synthesis of AgIn S2 QDs in droplet microreactors: Online fluorescence regulating through temperature control

Haotian Ma, Liangjun Pan, Ji Wang, Li Zhang, Zhiling Zhang

Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China

We designed a temperature-controllable droplet microreactor with more precisely temperature control and shorter synthesis time for w ater-soluble AgInS2QDs synthesis. When reaction temperature increased from 30 ?C to 70 ?C, QDs fluorescence peak constantly red-shifted from 590 nm to 720 nm along with enhanced fluorescence QY and intensity, we can get products with the maximum fluorescence intensity and the QY of 8.8% at 70 ?C.

Chinese Chemical Letters 30 (2019) 79

Evaluation of necrosis avidity of radioiodinated 5-hydroxytryptophan and its potential applications in myocardial infarction imaging

Lin Maa,b,c, Lingqiao Caib,c,d, Qiaomei Jinb,c, Jiajia Lianga,b,c, Dongjian Zhangb,c, Wei Liue,Yicheng Nif, Zhiqi Yina, Jian Zhangb,c, Ke Pana

aDepartment of Natural Medicinal Chemistry & Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China

bAffliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, China

cLaboratories of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, China

dCollege of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China

eDepartment of Nuclear Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

fTheragnostic Laboratory, Campus Gasthuis berg, KULeuven, 3000 Leuven, Belgium

[131I]5-HTP features predominant necrosis avidity and could rapidly visualize necrotic myocardium at 3 h p.i. The necrosis avidity mechanism of [131I]5-HTP may be attributed to its interactions with E-DNA in the necrotic tissues.

Chinese Chemical Letters 30 (2019) 83

Cancer cell detection and imaging: MRI-SERS bimodal splat-shaped Fe3O4/Au nanocomposites

Xinmei Zhaoa,b, Leyong Zenga, Narayan Hosmanec, Yan Gongd, Aiguo Wua

aCAS Key Laboratory of Magnetic Materials and Devices & Division of Functional Materials and Nanodevices,Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China

bZhejiang Pharmaceutical College, Ningbo 315100, China

cDepartment of Chemistry & Biochemistry, Northern Illinois University, DeKalb, Illinois 60115-2862, United States

dNingbo Eye Hospital, Ningbo 315040, China

In this paper, a kind of splat-shaped Fe3O4/Au nanocomposites was synthesized. The magnetic resonance imaging/surface-enhanced Raman scattering (MRI/SERS) studies demonstrated that as-synthesized Fe3O4/Au nanocomposites may be a promising MRI/SERS dual probe for the tumor detection.

Chinese Chemical Letters 30 (2019) 87

Effects of the ambient fine particulate matter (PM2.5) exposure in rats using UPLC-Q-TOF-MS

Zhang Zhanga,b, Tengfei Xua, Zifeng Pia, Meizhu Zhengc, Fengrui Songa, Zhiqiang Liua

aChangchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun Center of Mass Spectrometry,Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry, Changchun 130022, China

bSchool of Pharmaceutical Sciences, Jilin University, Changchun 130021, China

cThe Central Laboratory, Changchun Normal University, Changchun 130032, China

The pathogenesis of PM2.5 was evaluated on rats in model groups using a metabonomic method by UPLC-Q-TOF-MS and 17 potential endogenous metablites were identified. The primary metabolism pathways involved pentose and glucuronate interconversions, starch and sucrose metabolism, tryptophan metabolism, tyrosine metabolism,phenylalanine metabolism, purine metabolism, acetaminophen metabolism pathway, retinol metabolism and valproic acid metabolism pathw ay.

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A membrane separation technique for optimizing sample preparation of MALDI-TOF MS detection

Zengnan Wua,b, Ning Xub, Weiwei Lib, Jin-Ming Linb

aState Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China

bBeijing KeyLaboratory of Microanalytical Methods and Instrumentation, Department of Chemistry, Tsinghua University, Beijing 100084, China

Here, we report a new method based on the combination of membrane separation technology and nanomaterial to rapid detection of peptides and protein with MALDI-TOF MS. This method show s advantages as it can inhibit the heterogeneous of sample spot and enhance the target molecular signal intensity.

Chinese Chemical Letters 30 (2019) 95

Construction of on-line supercritical fluid extraction with reverse phase liquid chromatography–tandem mass spectrometry for the determination of capsaicin

Naoki Hamadaa,b, Yuki Hashib, Satoshi Yamakib, Yanli Guob, Lin Zhangb, Haifang Lia,Jin-Ming Lina

aBeijing Key Laboratory of Microanalytica Methods and Instrumentation, MOE Key Laboratory of Bioorganic Phosphorous Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084,China

bChina MS Center, Shimadzu (China) Co., Beijing Branch, Beijing 100020, China

A column-sw itching system, composed of supercritical fluid extraction (SFE) and reverse phase liquid chromatography/mass spectrometry (RPLC/MS) was constructed for on-line extraction and reverse-phase separation of capsaicinoids in capsicum fruits.

Chinese Chemical Letters 30 (2019) 99

Analysis of the binding sites with NL-101 to amino acids and peptides by HPLC/MS/MS

Lingzi Daia, Nian Guoa, Yaqin Liua, Shanshan Shena, Qiufu Geb, Yuanjiang Pana

aDepartment of Chemistry, Zhejiang University, Hangzhou 310027, China

bHangzhou Pharmaceutical Group Co., Ltd., Hangzhou 311100, China

Collision-induced dissociation experiment demonstrated that under the same collision energy,different fragmentation pattern could help distinguish the accurate location of amino acids-NL adducts.

Chinese Chemical Letters 30 (2019) 103

Dissipation behavior, residue distribution and dietary risk assessm ent of chlorfenapyr and clothianidin in leek using RRLC-Qq Q-MS/MS technique

Xi Li, Xiaoxin Chen, Jiye Hu

College of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083,China

Commercial suspension emulsion (SE) of (8% chlorfenapyr + 20% clothianidin), as a pre-registered product in China, was fi rstly investigated under Chinese open-fi eld conditions. A MWCNTs-based QuEChERS method for simultaneous determination of chlorfenapyr and clothianidin in leek was established and validated through RRLC-QqQ-MS/MS.

Chinese Chemical Letters 30 (2019) 107

Determination of triglycerides in human serum by near-infrared diffuse reflectance spectroscopy using silver mirror as a substrate

Shuyu Wanga, Jin Zhanga, Cuicui Wanga, Xiaoming Yub, Wensheng Caia, Xueguang Shaoa,c,d,e

aResearch Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin 300071, China

bLaboratory of Clinic, People’s Hospital of Gaomi City, Gaomi 261500, China

cTianjin Key Laboratory of Biosensing and Molecular Recognition, Tianjin 300071, China

dState Key Laboratory of Medicinal Chemical Biology, Tianjin 300071, China

eCollaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, China

Quantitative determination of serum triglycerides was achieved in diffuse refl ectance mode using silver mirror as the substrate to enhance the spectral features.

Chinese Chemical Letters 30 (2019) 111

ATR-FTIR study of Bacillus sp. and Escherichia coli settlements on the bare and Al2O3 coated Zn Se internal reflection element

Rongqiao Chena,b, Chune Guoa, Wubo Chua, Nan Jianga, He Lia

aKey Laboratory of Marine Materials and Related Technologies, CAS, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences,Ningbo 315201, China

bNano Science and Technology Institute, University of Science and Technology of China, Suzhou 21500, China

FTIR-ATR has been used for understanding the interaction between bacteria and surfaces in the adsorption progress.

Chinese Chemical Letters 30 (2019) 115

Redox-responsive diphenylalanine aggregate mediated by cyclodextrin

Lu Zhanga, Ying-Ming Zhanga, Guoxing Liua, Yu Liua,b

aCollege of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China

bCollaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University,Tianjin 300072, China

The molecular assembling behaviours between ferrocene-modified diphenylalanine and ?-cyclodextrin were investigated, which showed a reversible morphological conversion by the chemical redox of ferrocenyl moiety.

Chinese Chemical Letters 30 (2019) 120

Supram olecular conducting m icrofibers from am phiphilic tetrathiafulvalene-based organogelator

Xuemei Lianga, Lei Wangb,c, Kw angun Jeongb, Myonghoon Leeb

aCollege of Information Technology, Jilin Agricultural University, Changchun 130118, China

bDepartment of Polymer/Nano Science and Technology, Chonbuk National University, Jeonju 561756,Republic of Korea

cNational Center for Nano science and Technology (NCNST), Beijing 100190, China

An amphiphilic tetrathiafulvalene molecule can gelate a variety of organic solvents in view of multiple intermolecular interactions, especially in polar solvent with the formation of highly-ordered columnar structures. The formation of mixed-valence states shows the semiconductive behaviors with the conductivity of 10-4S/cm, as promising candidates for organic electronics.

Chinese Chemical Letters 30 (2019) 123

Self-assembly of supramolecular polymers in water from tetracationic and tetraanionic monomers in water through cooperative electrostatic attraction and aromatic stacking

Ya-Kun Zhao, Zhong-Zheng Gao, Hui Wang, Dan-Wei Zhang, Zhan-Ting Li

Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), Fudan University,Shanghai 200438, China

The cooperative electrostatic attraction and π-π stacking between tetrahedral tetrapyridinium and three tetraanionic tetraphenylethylenes led to the formation of a new series of supramolecular polymers in water.

Chinese Chemical Letters 30 (2019) 127

Facile construction of Zn(II)-porphyrin-cored [5]rotaxane and its controllable aggregation behaviours

Menglan Hea, Lijun Chena, Bo Jianga, Hongwei Tanb, Cuihong Wanga, Haibo Yanga

aShanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, Chin a

bDepartment of Chemistry, Beijing Normal University, Beijing 100050, China

A novel Zn(II)-porphorin-cored [5]rotaxane with platinum-acetylide as linkage was constructed.The obtained [5]rotaxane performed different morphologies in different solvents. In addition,the ordered morphologies generated from [5]rotaxane exhibited the morphology evolution by time.

Chinese Chemical Letters 30 (2019) 131

To inhibit coffee ring effect in inkjet printing of light-emitting polymer films by decreasing capillary force

Xinhong Yu, Rubo Xing, Zhongxiang Peng, Yangming Lin, Zhonghui Du, Junqiao Ding,Lixiang Wang, Yanchun Han

State Key Laboratory of Polymer Physicsand Chemistry, Changchun Institute of Applied Chemistry,Chinese Academy of Sciences, Changchun 130022, China

Coffee ring effects of inkjet printed poly(spirobifl uorene) fi lms were restrained by decreasing the capillary force due to volatility/viscosity match.

Chinese Chemical Letters 30 (2019) 135

Handedness inversion of chiral mesoporous silica:A diffuse-reflectance circular dichroism study

Nan Wang, Ruiyu Lin, Minzhao Xue, Yingying Duan, Shun′ai Che

aSchool of Chemistry and Chemical Engineering, State Key Laboratory of Composite Materials, Shanghai Jiao Tong University, Shanghai 200240, China

bSchool of Chemical Science and Engineering, Tongji University, Shanghai 200092, China

Temperature-depended handedness inversion in chiral mesoporous silica was investigated by diffuse-refl ectance circular dichroism spectra.

Chinese Chemical Letters 30 (2019) 139

Effective enhancement of the emission efficiency of tetraphenylporphyrin in solid state by tetraphenylethene modification

Nan Jianga, Yijia Wanga, Anjun Qinb, Jing Zhi Suna, Ben Zhong Tanga,b,c

aMOE Key Laboratory of Macromolecular Synthesisand Functionalization, Department of PolymerScienceand Engineering, Zhejiang University, Hangzhou 310027, China

bGuangdong Innovative Research Team, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510641, China

cDepartment of Chemistry, Institute for Advanced Study, Institute of Molecular Functional Materials, and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science & Technology, Hong Kong, China

Evidently enhanced red emission effi ciency from the solid state of tetraphenylporphyrin derivative was achieved by modifi cation with tetraphenylethene units.

Chinese Chemical Letters 30 (2019) 143

Creating super-tough and strong PA6/ABS blends using multi-phase compatibilizers

Xianwei Sui, Xu-Ming Xie

Key Laboratory of Advanced Materials (MOE), Department of Chemical Engineering, Tsinghua University,Beijing 100084, China

PA6/ABS blends with excellent mechanical properties are prepared using combination of two effective multi-phase compatibilizers, w here finely dispersed domains with unique encapsulation structures are generated for the synergistic improvement in tensile and impact performances.

Chinese Chemical Letters 30 (2019) 149

Living and enantiomer-selective polymerization of allene initiated by Ni complex containing chiral phosphine

Hai Zhua,b, Shizhong Luoa, Zongquan Wub

aCollege of Chemistry and Materials Science, The Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecular-Based Materials, Center for Nano Science and Technology,Anhui Normal University, Wuhu 241000, China

bDepartment of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, Hefei University of Technology and Anhui Key Laboratory of Advanced Catalytic Materials and Reaction

Engineering, Hefei 230009, China

In the polymerization of chiral allene by using chiral phosphine complex, the polymerization rate of L-1 is approximately 1.9 times that of D-1. This catalyst has enantiomer-selectivity for the polymerization of chiral allene derivative monomer.

Chinese Chemical Letters 30 (2019) 153

Coaxial electrospinning core-shell fibers for self-healing scratch on coatings

Pengchong Li, Zhi Shang, Kejian Cui, Huan Zhang, Zhi Qiao, Caizhen Zhu, Ning Zhao, Jian Xu

aCollege of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China

bBeijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences,Beijing 100190, China

Polystyrene (PS) fibers with core-shell structure were prepared by coaxial electrostatic spinning using liquid epoxy or curing agent as the core and PS solution as the shell. Scratch self-healing coatings were realized by using the healant-loaded core-shell fibers in the matrix.

Chinese Chemical Letters 30 (2019) 157

A novel ?-fetoprotein-MIP immunosensor based on Au NPs/PTh modified glass carbon electrode

Yuxuan Laia, Chuanxiang Zhanga, Yan Denga,c, Gaojian Yanga, Song Lia, Congli Tanga,Nongyue Hea,c

aHunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou 412007, China

bCollege of Packing and Materials Engineering, HunanUniversity of Technology, Zhuzhou 412007, China

cState Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China

A new alpha-fetoprotein-MIP (AFP-MIP) immunosensor based on glass carbon electrode (GCE) modified with polythionine (PTh) and gold nanoparticles (AuNPs) was successfully prepared for the sensitive detection of AFP. The AFP-MIP immunosensor presented a facile preparation, low sample consumption, and good stability,and could become a new promising method for the detection of AFP.

Chinese Chemical Letters 30 (2019) 160

Nanoparticle structure transformation of m PEG grafted chitosan with rigid backbone induced by ?-cyclodextrin

Lei Huangb, Jiaojiao Chenb, Muye Heb, Xinyu Houb, Yiben Lub, Kaiyan Loub,c, Feng Gaoa,b,c

aShanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology, Shanghai 200237, China

bDepartment of Pharmaceutics, School of Pharmacy, East China University of Science and Technology,Shanghai 200237, China

cShanghai Key Laboratory of New Drug Design, East China University of Science and Technology, Shanghai 200237, China

This paper presented an interesting nanoparticle-based drug-delivery system with morphology transition behavior depending on the content of exposed PEG chain on the particle surface and a likely mechanism for the morphological transition of the rod-coil graft copolymer m PEG-g-CS was proposed.

Chinese Chemical Letters 30 (2019) 163

Preparation of Au nanoparticles modified TiO2 nanotube array sensor and its application as chemical oxygen demand sensor

Longqi Lianga, Jiao Yinb, Jinpeng Baoa, Linchuan Conga, Weimin Huanga, Haibo Linc, Zhan Shid

aCollege of Chemistry, Jilin University, Changchun 130012, China

bKey Laboratory of Functional Materials and Devices for Special Environments, Xinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences, Urumqi 830011, China

cGuangdong Guanghua Sci-Tech Co., Ltd., Shantou 515061, China

dCollege of Chemistry, State Key Laboratory Inorganic Synthesis & Preparative Chemistry, Jilin University,Changchun 130012, China

Au nanoparticles (AuNPs) were electrodeposited at the highly ordered anatase TiO2nanotube array (TiO2NA)electrode to prepare the AuNP-TiO2NA sensor. The as-prepared sensor can be used for the determination of chemical oxygen demand (COD) in real samples.

Chinese Chemical Letters 30 (2019) 167

Facile hydrothermal-thermal conversion synthesis of CaSiO3 nanow ires as promising structure and function integrated photoluminescent host candidate

Lin Xu, Panpan Sun, Xiuping Chen, Peiyan Zhai, Wancheng Zhu

Department of Chemical Engineering, Qufu Normal University, Qufu 273165, China

A facile green hydrothermal-thermal conversion method was developed for the uniform high aspect ratio CaSiO3nanow ires as promising structure and function integrated photoluminescent host, without any organic additive.

Chinese Chemical Letters 30 (2019) 171

Controllable self-assembly of parallel gold nanorod clusters by DNA origami

Hang Yua, Tiantian Manb, Wei Jib, Leilei Shia, Chenwei Wua, Hao Peib, Chuan Zhanga

aSchool of Chemistry and Chemical Engineering, Shanghai Key Laboratory of Electrical Insulation and Thermal Ageing, Shanghai Jiao Tong University, Shanghai 200240, China

bShanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China

We demonstrate the self-assembly of three types of parallel gold nanorod clusters using a rod-like DNA origami as the template.

Chinese Chemical Letters 30 (2019) 175

A multiple coupling approach to produce high-performance SERS substrates

Xianpeng Yin, Hao Dong, Shiqiang Wang, Yun Liang, Ning Gao, Wanlin Zhang, Li Tian,Fuwei Sun, Guangtao Li

Department of Chemistry, Key Lab of Organic Optoelectronics and Molecular Engineering, Tsinghua University,Beijing 100084, China

In this work, large area gold-nanoparticle-cluster pillar array with a gold mirror as high-performance SERS substrate was facilely fabricated by combined use of nanosphere lithography and self-assembly approach.

Chinese Chemical Letters 30 (2019) 179

Facile-fabricated iron oxide nanorods as a catalyst for hydrogenation of nitrobenzene

Yanshuang Maa,b, Liyun Zhanga, Wen Shia,b, Yiming Niua,b, Bingsen Zhanga, Dangsheng Sua

aShenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences,Shenyang 110016, China

bSchool of Materials Science and Engineering, University of Science and Technology of China, Hefei 230026,China

Iron oxide nanorod catalysts were fabricated by wet chemistry method followed annealing.The facilefabricated FeOOH nanorods with an effi cient catalytic performance for transfer hydrogenation of nitrobenzene with hydrazine hydrate are presented.

Chinese Chemical Letters 30 (2019) 183

One-pot photoreduction to prepare NIR-absorbing plasm onic gold nanoparticles tethered by amphiphilic polypeptide copolym er for synergistic phototherm al-chem otherapy

Siqi Yanga, Linzhu Zhoua, Yue Sua, Rong Zhangb, Chang-Ming Donga,b

aSchool of Chemistry and Chemical Engineering, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong University, Shanghai 200240, China

bJoint Research Center for Precision Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai Fengxian Central Hospital, Shanghai 201400, China

We developed one-pot photoreduction strategy to fabricate the NIR-absorbing plasmonic PLC-b-PEO@Au NPs.It possessed strong NIR absorption at 700-1100 nm, an ultrahigh photothermal conversion effi ciency of 62.1%,and good photostability.

Chinese Chemical Letters 30 (2019) 187

Ultrafine molybdenum carbide nanoparticles supported on nitrogen doped carbon nanosheets for hydrogen evolution reaction

Kedong Xia, Junpo Guo, Cuijuan Xuan, Ting Huang,Zhiping Deng, Lingxuan Chen, Deli Wang

Key laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology), Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China

Nitrogen doped carbon nanosheets supported molybdenum carbides nanoparticles (MoxC/NCS) have been synthesized by tuning the mass ratio of melamine and ammonia molybdate. The Mo2C/NCS-10 exhibits superior electrocatalytic performance and stability for HER, which was attributed to N-doped carbon nanosheets, small particle size, mesoporous structure, and large electrochemical active surface area.

Chinese Chemical Letters 30 (2019) 192

MoS2 decorated lignin-derived hierarchical mesoporous carbon hybrid nanospheres with exceptional Li-ion battery cycle stability

Feng Chena, Long Wua, Zeping Zhoua, Jiajun Jub, Zhengping Zhaoc, Mingqiang Zhonga,Tairong Kuangb

aCollege of Material Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, China

bThe Key Laboratory of Polymer Processing Engineering of Ministry of Education, South China University of Technology, Guangzhou 510640, China

cZhijiang College, Zhejiang University of Technology, Hangzhou 310014, China

We developed a feasible self-assembly and carbonization method to prepare lignin-derived porous carbon nanosphere (PCN) and its effi cient embedment of MoS2without any additives. The obtained hybrid nanocomposite provides a possible route to develop high performance Li-ion battery from natural biomass or organizational structures.

Chinese Chemical Letters 30 (2019) 197

Ethylenediamine promoted the hydrogenative coupling of nitroarenes over Ni/C catalyst

Youdi Yanga,b, Shaopeng Lia,b, Chao Xiea,b, Hangyu Liua,b, Yanyan Wanga,b, Qingqing Meia,Huizhen Liua,b, Buxing Hana,b

aBeijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Colloid and Interface and Thermodynamics, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry,Chinese Academy of Sciences, Beijing 100190, China

bSchool of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, China

In this work, we found that ethylenediamine can enrich the electron state of Ni and make the azobenzene easily desorb from the surface of the catalyst, which effectively inhibits the further hydrogenation to aniline and greatly improves the selectivity of azobenzene. When the ratio of Ni and ethylenediamine is 1:10, the yield of the azobenzene can reach 95.5%.

Chinese Chemical Letters 30 (2019) 203

First-principles study of m ethanol adsorption on heteroatomdoped phosphorene

Dongdong Liua, Yongliang Shib, Li Taob, Dafeng Yana, Ru Chena, Shuangyin Wanga,c,d

aState Key Laboratory of Chem/Bio-Sensing and Chemometrics, Provincial Hunan Key Laboratory for Graphene Materials and Devices, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China

bICQD/Hefei National Laboratory for Physical Sciences at Microscale, and Key Laboratory of Strongly-Coupled Quantum Matter Physics, Chinese Academy of Sciences and Department of Physics, University of Science and Technology of China, Hefei 230026, China

cKey Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province,Shenzhen University, Shenzhen 518060, China

dShenzhen Research Institute of Hunan University, Shenzhen 518057, China

First-principles calculations were fi rstly employed to investigate the adsorption of methanol on pristine and X-doped phosphorene (X = B, C, N and O). The N and O doping improved the adsorption of phosphorene with CH3OH gas molecule, while B and C doping were almost not benefi cial.

Chinese Chemical Letters 30 (2019) 207

Electronic, optical, and charge transport properties of A-?-A electron acceptors for organic solar cells: Impact of anti-aromatic? structures

Yan Zenga,b, Ruihong Duanb, Yuan Guob, Guangchao Hanb, Qingxu Lia, Yuanping Yib

aSchool of Science, Chongqing University of Posts and Telecommunications, Chongqing 400065, China

bCAS Key Laboratory of Organic Solids, CAS Research/Education Center for Excellence in Molecular Sciences,Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

Anti-aromatization and isomerization are found to be an effective w ay to tune the optoelectronic properties of A-?-A electron acceptors for organic photovoltaics.

Chinese Chemical Letters 30 (2019) 211

Effects of processing additives in non-fullerene organic bulk heterojunction solar cells with efficiency ?11%

Shenkun Xiea, Jianqiu Wanga, Rong Wangb, Dongyang Zhangb, Huiqiong Zhouc, Yuan Zhangb,Defeng Zhoua

aSchool of Chemistry and Life Science, Changchun University of Technology, Changchun 130012, China

bHEEGER Beijing Research & Development Center, School of Chemistry, Beihang University, Beijing 100191, China

cCAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology, Beijing 100190, China

The solar cell surface morphologies with different additives observed with slightly changed in roughness.

It is easily to get the best PCE of 11.1% with using 0.5% DIO additives.

Chinese Chemical Letters 30 (2019) 217

Simple non-fullerene electron acceptors with unfused core for organic solar cells

Yao Lia,b, Yunhua Xua, Fan Yangb, Xudong Jiangb, Cheng Lib, Shengyong Youc, Weiwei Lib,c

aDepartment of Chemistry, School of Science, Beijing Jiaotong University, Beijing 100044, China

bBeijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Organic Solids, Institute of Chemistry,Chinese Academy of Sciences, Beijing 100190, China

cInstitute of Applied Chemistry, Jiangxi Academy of Sciences, Nanchang 330096, China

Tw o simple unfused-cores based electron acceptors with different side units were developed for application in non-fullerene solar cells, in which the side chains have the signifi cant effect on their absorption spectra and photovoltaic performance.

Chinese Chemical Letters 30 (2019) 222

Photocatalytic hydrogen production from acidic aqueous solution in BODIPY-cobaloxime-ascorbic acid homogeneous system

An Xiea, Zhong-Hua Panc, Miao Yuc, Geng-Geng Luoc, Di Sunb

aSchool of Materials Science and Engineering, Xiamen University of Technology, Xiamen 361024, China

bSchool of Chemistry and Chemical Engineering, Shandong University, Ji’nan 250100, China

cFujian Key Laboratory of Photoelectric Functional Materials, College of Materials Science and Engineering,Huaqiao University, Xiamen 361021, China

For the fi rst time, iodinated BODIPY dyes with phenylamine or 8-hydroxylquinoline moiety at the meso-position on the BODIPY core were tested for the light-driven production of H2from the acidic aqueous solutions.

Chinese Chemical Letters 30 (2019) 225

Co1-x S embedded in porous carbon derived from metal organic framework as a highly efficient electrocatalyst for oxygen evolution reaction

Denghong He, Xiaolin Wu, Wei Liu, Chaojun Lei, Chunlin Yu, Guokui Zheng, Junjie Pan,Lecheng Lei, Xingwang Zhang

Key Laboratory of Biomass Chemical Engineering of Ministry of Education, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China

Here, we report a tw o-step conversion method to fabricate a composite of Co1-xS embedded in porous carbon framework (Co1-xS@C) derived from metal organic frameworks (MOFs). The as-prepared porous dodecahedron Co1-xS@C composite catalyst exhibits excellent electrocatalytic performance towards oxygen evolution reaction (OER).

Chinese Chemical Letters 30 (2019) 229

An anionic In(III)-based metal-organic framework with Lewis basic sites for the selective adsorption and separation of organic cationic dyes

Qi Yang, Bin Wang, Ya Chen, Yabo Xie, Jianrong Li

Beijing Key Laboratory for Green Catalysis and Separation and Department of Chemistry and Chemical Engineering, College of Environmental and Energy Engineering, Beijing University of Technology,Beijing 100124, China

An In(III)-based metal-organic framework (BUT-29) can selectively absorb cationic dyes in DMF even in the presence of other organic dyes, and has the higher adsorption capacity.

Chinese Chemical Letters 30 (2019) 234

Biologically inspired silk fibroin grafted polyacrylonitrile filtration membrane prepared in Zn Cl2 aqueous solution

Jingang Lia, Shuwen Lia, Xiaohui Wanga, Fan Fanb, Kongyin Zhaoa, Junfu Weia, Linhua Zhangb,Dunwan Zhub

aState Key Laboratory of Separation Membranes and Membrane Processes, Tianjin Polytechnic University,Tianjin 300387, China

bTianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China

Biologically inspired silk fi broin grafted polyacrylonitrile (SF-g-PAN) fi ltration membrane was prepared using Zn Cl2aqueous solution as solvent, avoiding the use of organic solvents.

Chinese Chemical Letters 30 (2019) 239

Design, synthesis and biological evaluation of a novel platinum(II) complex possessing bioreductive groups for cancer therapy

Chengken Chena,b, Chunmei Gaoc, Zigao Yuanb,e, Yuyang Jiangb,d,e

aDepartment of Chemistry, Tsinghua University, Beijing 100084, China

bThe Ministry-Province Jointly Constructed Base for State Key Lab-Shenzhen Key Laboratory of Chemical Biology,The Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China

cCollege of Chemistry and Chemical Engineering, Shenzhen University, Shenzhen 518060, China

dDepartment of Pharmacology and Pharmaceutical Sciences, School of Medicine, Tsinghua University, Beijing 100084, China

eShenzhen Kivita Innovative Drug Discovery Institute, Shenzhen 518055, China

A Pt(II) complex possessing bioreductive groups was constructed and evaluated as a more potent antitumor agent than cisplatin.

Design and synthesis of novel water-soluble amino acid derivatives of chlorin p6 ethers as photosensitizer

Xingjie Zhanga, Zhi Menga, Zhiqiang Maa, Junhong Liua, Guiyan Hana, Fujia Mab, Ningyang Jiac,Zhenyuan Miaoa, Wannian Zhanga, Chunquan Shenga, Jianzhong Yaoa

aDepartment of Medicinal Chemistry, Schoolof Pharmacy, Second Military Medical University, Shanghai 200433,China

bDepartment of Pharmacy, 455th Hospital of Chinese People’s Liberation Army, Shanghai 200052, China

cDepartment of Radiology, Shanghai Eastern Hepatobiliary Surgery Hospital, Second Military Medical University,Shanghai 200438 Chinaa

Eight new water-soluble amino acid derivatives of chlorin p6ethers 6a-h were designed and synthesized using purpurin-18 (2) as key intermediate. All target compounds exhibited better phototoxicity than talaporfi n and the most phototoxic compound 6d showed IC50values of 0.20 μmol/L against A549 cell and 0.41 μmol/L against B

16-F10 cell, which represented 31- and 24-fold increase of PDT antitumor effi cacy compared to talaporfi n.

Chinese Chemical Letters 30 (2019) 247

Novel dual inhibitors against FP-2 and Pf DHFR as potential antimalarial agents: Design, synthesis and biological evaluation

Wenhua Chena, Xue Yaoa, Zhenghui Huangb, Fei Maoa, Longfei Guana, Yun Tanga, Hualiang Jianga,Jian Lia, Jin Huanga, Lubin Jiangb, Jin Zhua

aShanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

bKey Laboratory of Molecular Virology & Immunology, Unit of Human Parasite Molecular and Cell Biology,Institute Pasteur of Shanghai, University of Chinese Academy of Science, Shanghai 200031, China

A series of novel 2,4-diaminopyrimidine-modified compounds was designed and synthesized. Compound 14 showed micromolar dual inhibitory effect on both FP-2 and PfDHFR, and potential inhibition to the proliferation of P. falciparum 3D7 strain and chloroquine-resistant P. falciparum Dd2 strain.

Chinese Chemical Letters 30 (2019) 250

Water bridges are essential to neonicotinoids: Insights from synthesis, bioassay and molecular modelling studies

Chengchun Zhua, Guanglong Lia, Keya Xiaoa, Xusheng Shaoa, Jiagao Chenga, Zhong Lia,b

aShanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China

bShanghai Collaborative Innovation Center for Biomanufacturing Technology, Shanghai 200237, China

To identify the detailed roles of water bridges in neonicotinoids recognition, twenty-four neonicotinoids compounds were designed, synthesized, bioassayed and modelled. Of all nine fragments mimicking water bridges, cyano group was the optimal one. The insecticidal activities indicated that the water bridge might be stable in the active site and was not suitable to be replaced by other groups, which highlighted the signifi cance of w ater bridges for neonicotinoids.

Chinese Chemical Letters 30 (2019) 255

Tetra-phthalimide end-fused bifluorenylidene: Synthesis and characterization

Debin Xia, Fangyuan Zhang, Zhigang Liu, Linghao Meng, Ruiqing Fan, Yulin Yang

MIIT Key Laboratory of Critical Materials Technology for Newenergy Conversion and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China

A novel electron acceptor, namely, tetra-phthalimide end-fused bifl uorenylidene (3D-imide) was designed and synthesized.

Chinese Chemical Letters 30 (2019) 259

Gram-scale preparation of dialkylideneacetones through Ca(OH)2-catalyzed Claisen-Schmidt condensation in dilute aqueous EtOH

Hao Zhanga,b, Mengting Hanb, Chenggen Yangb, Lei Yua,b, Qing Xub

aGuangling College, Yangzhou University, Yangzhou 225002, China

bSchool of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China

A practical synthetic method of dialkylideneacetones has been developed. Compared with know n protocols,the method employed catalytic Ca(OH)2as the cheap, mild base catalyst and dilute aqueous EtOH (20%, v/v)as the green and safe solvent. The products could be synthesized in gram-scale and isolated by a simple fi ltration.

Chinese Chemical Letters 30 (2019) 263

One-pot synthesis of tetrahydroindoles via a copper catalyzed N-alkynation/[4+2] cycloaddition cascade

Chun Jiang, Piao-Piao Yu, Qing Zhang, Hua-Dong Xu, Mei-Hua Shen

School of Pharmaceutical Engineering & Life Science, Changzhou University, Changzhou 213164, China

4,7-Dihydroindolines are prepared from alkyne bromides and 2-dienyl sulfonamides via a CuSO4catalyzed cascade in a one-pot fashion.

Chinese Chemical Letters 30 (2019) 266

A one-pot protocol for copper-mediated azide–alkyne cycloaddition using alkenyl triflate precursors

Yu Chena,b, Lianchao Liub, Dimin Wub, Yu-Peng Hea, Ang Lib

aCollege of Chemistry, Chemical Engineering and Environmental Engineering, Liaoning Shihua University,Fushun 113001, China

bState Key Laboratory of Bioorganic and Natural Products Chemistry, Center for Excellence in Molecular Synthesis,Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Taking advantage of LiCl-promoted elimination of alkenyl trifl ates, we developed a one-pot protocol for copper-mediated azide–alkyne cycloaddition using alkenyl trifl ate precursors, which may fi nd potential use in sequential click reactions.

Chinese Chemical Letters 30 (2019) 269