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        Treg細(xì)胞和Th17細(xì)胞的研究進(jìn)展

        2017-10-19 06:40:15陳碩聶漢祥劉琳琳
        臨床肺科雜志 2017年10期
        關(guān)鍵詞:武漢大學(xué)內(nèi)科研究進(jìn)展

        陳碩 聶漢祥 劉琳琳

        Treg細(xì)胞和Th17細(xì)胞的研究進(jìn)展

        陳碩 聶漢祥 劉琳琳

        一、Treg細(xì)胞和Th17細(xì)胞的分化和發(fā)育

        二、Treg與Th17在各種疾病中的作用

        三、總結(jié)

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        [7] Chen Z,Lin F,Gao Y,et al.FOXP3 and RORγt: transcriptional regulation of Treg and Th17[J].Int Immunopharmacol,2011,11(5):536-542.

        [8] Yang XO,Nurieva R,Martinez GJ,et al.Molecular antagonism and plasticity of regulatory and inflammatory T cell programs[J].Immunity,2008,29(1):44-56.

        [9] Deknuydt F,Bioley G,Valmori D,et al.IL-1beta and IL-2 convert human Treg into T(H)17 cells[J].Clin Immunol,2009,131(2):298-307.

        [10] Laurence A,Tato CM,Davidson TS,et al.Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation[J].Immunity,2007,26(3):371-381.

        [11] Amadi-Obi A,Yu CR,Liu X,et al.TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1[J].Nat Med,2007,13(6):711-718.

        [12] Komatsu N,Okamoto K,Sawa S,et al.Pathogenic conversion of FOXP3+T cells into TH17 cells in autoimmune arthritis[J].Nat Med,2014,20(1):62-68.

        [13] Miyao T,Floess S,Setoguchi R,et al.Plasticity of Foxp3(+) T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells[J].Immunity,2012,36(2):262-275.

        [14] Barbi J,Pardoll D,Pan F.Metabolic control of the Treg/Th17 axis[J].Immunol Rev,2013,252(1):52-77.

        [15] Wang R,Green DR.Metabolic reprogramming and metabolic dependency in T cells[J].Immunol Rev,2012,249(1):14-26.

        [16] Waickman AT,Powell JD.mTOR,metabolism, and the regulation of T-cell differentiation and function[J].Immunol Rev,2012,249(1):43-58.

        [18] Kim KW,Chung BH,Kim BM,et al.The effect of mammalian target of rapamycin inhibition on T helper type 17 and regulatory T cell differentiation in vitro and in vivo in kidney transplant recipients[J].Immunology,2015,144(1):68-78.

        [19] Kurebayashi Y,Nagai S,Ikejiri A,et al.PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORγ[J].Cell Rep,2012,1(4):360-373.

        [20] Delgoffe GM,Pollizzi KN,Waickman AT,et al.The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2[J].Nat Immunol,2011,12(4):295-303.

        [21] Nizet V,Johnson RS.Interdependence of hypoxic and innate immune responses[J].Nat Rev Immunol,2009,9(9):609-617.

        [22] Dang EV,Barbi J,Yang HY,et al.Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1[J].Cell,2011,146(5):772-784.

        [23] Kimura A,Naka T,Nohara K,et al.Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells[J].Proc Natl Acad Sci USA,2008,105(28):9721-9726.

        [24] Ganesan AP,Johansson M,Ruffell B,et al.Tumor-infiltrating regulatory T cells inhibit endogenous cytotoxic T cell responses to lung adenocarcinoma[J].J Immunol,2013,191(4):2009-2017.

        [25] Wang W,Hodkinson P,McLaren F,et al.Small cell lung cancer tumour cells induce regulatory T lymphocytes, and patient survival correlates negatively with FOXP3+cells in tumour infiltrate[J].Int J Cancer,2012,131(6):E928-E937.

        [26] Erfani N,Mehrabadi SM,Ghayumi MA,et al.Increase of regulatory T cells in metastatic stage and CTLA-4 over expression in lymphocytes of patients with non-small cell lung cancer (NSCLC)[J].Lung Cancer,2012,77(2):306-311.

        [27] Black CC,Turk MJ,Dragnev K,et al.Adenocarcinoma contains more immune tolerance regulatory t-cell lymphocytes (versus squamous carcinoma) in non-small-cell lung cancer[J].Lung,2013,191(3):265-270.

        [28] Ye J,Livergood RS,Peng G.The role and regulation of human Th17 cells in tumor immunity[J].Am J Pathol,2013,182(1):10-20.

        [29] Xu C,Hao K,Yu L,et al.Serum interleukin-17 as a diagnostic and prognostic marker for non-small cell lung cancer[J].Biomarkers,2014,19(4):287-290.

        [30] Reppert S,Boross I,Koslowski M,et al.A role for T-bet-mediated tumour immune surveillance in anti-IL-17A treatment of lung cancer[J].Nat Commun,2011,2:600.

        [31] Carmi Y,Rinott G,Dotan S,et al.Microenvironment-derived IL-1 and IL-17 interact in the control of lung metastasis[J].J Immunol,2011,186(6):3462-3471.

        [32] Li Q,Han Y,Fei G,et al.IL-17 promoted metastasis of non-small-cell lung cancer cells[J].Immunol Lett,2012,148(2):144-150.

        [33] Kobold S,V lk S,Clauditz T,et al.Interleukin-22 is frequently expressed in small- and large-cell lung cancer and promotes growth in chemotherapy-resistant cancer cells[J].J Thorac Oncol,2013,8(8):1032-1042.

        [35] Yosef N,Shalek AK,Gaublomme JT,et al.Dynamic regulatory network controlling TH17 cell differentiation[J].Nature,2013,496(7446):461-468.

        [36] Yuan J,Bagley J,Iacomini J.Iacomini.Hyperlipidemia Promotes Anti-Donor Th17 Responses That Accelerate Allograft Rejection[J].Am J Transplant,2015,15(9):2336-2345.

        [37] Bagley J,Yuan J,Chandrakar A,et al.Hyperlipidemia Alters Regulatory T Cell Function and Promotes Resistance to Tolerance Induction Through Costimulatory Molecule Blockade[J].Am J Transplant,2015,15(9):2324-2335.

        [38] Maganto-García E,Tarrio ML,Grabie N,et al.Dynamic changes in regulatory T cells are linked to levels of diet-induced hypercholesterolemia[J].Circulation,2011,124(2):185-195.

        [39] Smigiel KS,Richards E,Srivastava S,et al.CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets[J].J Exp Med,2014,211(1):121-136.

        [40] Cretney E,Kallies A,Nutt SL.Differentiation and function of Foxp3(+) effector regulatory T cells[J].Trends Immunol,2013,34(2):74-80.

        [41] Anderson GP.Endotyping asthma: new insights into key pathogenic mechanisms in a complex, heterogeneous disease[J].Lancet,2008,372(9643):1107-1119.

        [42] Raphael I,Nalawade S,Eagar TN,et al.T cell subsets and their signature cytokines in autoimmune and inflammatory diseases[J].Cytokine,2015,74(1):5-17.

        [43] Zhang JG,Chen XJ,Liu T,et al.FOXP3+associated with the pro-inflammatory regulatory T and T helper 17 effector cells in asthma patients[J].Exp Ther Med,2016,12(4):2753-2758.

        [44] Sadhu S,Khaitan BK,Joshi B,et al.Reciprocity between Regulatory T Cells and Th17 Cells: Relevance to Polarized Immunity in Leprosy[J].PLoS Negl Trop Dis,2016,10(1):e0004338.

        [45] Yan C,Zhang BB,Hua H,et al.The Dynamics of Treg/Th17 and the Imbalance of Treg/Th17 in Clonorchis sinensis-Infected Mice[J].PLoS One,2015,10(11):e0143217.

        10.3969/j.issn.1009-6663.2017.010.041

        430060 湖北 武漢,武漢大學(xué)人民醫(yī)院呼吸內(nèi)科

        聶漢祥,E-mail:nhxbj@sohu.com

        2017-02-10]

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