Bashir Ahmed Solangi,Jehangir Ali Shah,Rajesh Kumar,Mahesh Kumar Batra,Gulzar Ali,Muhammad Hassan Butt,Ambreen Nisar,Nadeem Qamar,Tahir Saghir,Jawaid Akbar Sial

Abstract BACKGROUND Cardiogenic shock (CS) is a life-threatening complication of acute myocardial infarction with high morbidity and mortality rates. Primary percutaneous coronary intervention (PCI) has been shown to improve outcomes in patients with CS.AIM To investigate the immediate mortality rates in patients with CS undergoing primary PCI and identify mortality predictors.METHODS We conducted a retrospective analysis of 305 patients with CS who underwent primary PCI at the National Institute of Cardiovascular Diseases, Karachi, Pakistan, between January 2018 and December 2022. The primary outcome was immediate mortality, defined as mortality within index hospitalization. Univariate and multivariate logistic regression analyses were performed to identify predictors of immediate mortality.RESULTS In a sample of 305 patients with 72.8% male patients and a mean age of 58.1 ± 11.8 years, the immediate mortality rate was found to be 54.8% (167). Multivariable analysis identified Killip class IV at presentation [odds ratio (OR): 2.0; 95% confidence interval (CI): 1.2-3.4; P = 0.008], Multivessel disease (OR: 3.5; 95%CI: 1.8-6.9; P ＜ 0.001), and high thrombus burden (OR: 2.6; 95%CI: 1.4-4.9; P = 0.003) as independent predictors of immediate mortality.CONCLUSION Immediate mortality rate in patients with CS undergoing primary PCI remains high despite advances in treatment strategies. Killip class IV at presentation, multivessel disease, and high thrombus burden (grade ≥ 4) were identified as independent predictors of immediate mortality. These findings underscore the need for aggressive management and close monitoring of patients with CS undergoing primary PCI, particularly in those with these high-risk characteristics.

Key Words: Acute myocardial infarction;Cardiogenic shock;Primary percutaneous coronary intervention;Mortality;Predictors

INTRODUCTION

The prevalence of myocardial infarction is estimated to vary by age group, with reported rates of 3.8% among individuals under 60 years of age and a higher prevalence of 9.5% among those aged 60 years and above. Within the context of acute myocardial infarction (AMI), a critical complication known as cardiogenic shock (CS) emerges as a life-threatening concern[1]. This condition stands as the leading cause of mortality associated with AMI, with reported incidence rates ranging from 5% to 15%[2,3]. CS is a medical emergency that occurs when the heart is unable to pump enough blood to meet the body's needs. It can be caused by a variety of conditions, including myocardial infarction (heart attack), cardiomyopathy, and valvular heart disease[3]. Management of CS involves identifying and treating the underlying cause and providing supportive care to stabilize the patient's condition[4]. In AMI, CS is a life-threatening complication with a high morbidity and mortality rate[5]. Primary percutaneous coronary intervention (PCI) has emerged as the preferred reperfusion strategy in patients with AMI and CS[6]. The main goal of primary PCI in patients with CS is to restore blood flow to the affected area of the heart, which can help to improve cardiac function and reduce mortality rates[4]. Compared to other revascularization strategies, such as thrombolysis or medical therapy alone, primary PCI has been shown to be more effective in restoring blood flow and improving outcomes in patients with CS[7].

Patients with CS are at risk of developing several in-hospital complications, which include; acute kidney injury (AKI) as a result of reduced kidney perfusion due to a decreased cardiac output and low blood pressure[8], arrhythmias such as atrial fibrillation and ventricular tachycardia[9], pulmonary edema due to excessive fluid administration or impaired cardiac function[10], and multi-organ failure due to impaired perfusion to vital organs as a result of prolonged hypotension and decreased cardiac output[10]. Additionally, invasive procedures such as PCI can increase the risk of bleeding complications[11], catheter-related bloodstream infections, and ventilator-associated pneumonia[12]. Also, CS is associated with an increased risk of thromboembolic events, as patients with reduced cardiac output and immobility are at increased risk of developing deep vein thrombosis and pulmonary embolism[10]. The development of these complications can further worsen the prognosis of patients with CS. Therefore, close monitoring and prompt management of these complications are essential in improving patient outcomes.

The management of CS requires a multidisciplinary approach involving cardiology, critical care, and interventional teams. Clinical precautions in the management of CS include several essential considerations. Firstly, early identification and diagnosis of CS is crucial, as early interventions have been shown to improve survival rates[13]. Therefore, healthcare providers should be vigilant for signs and symptoms of CS, such as hypotension, tachycardia, and decreased urine output. Secondly, revascularization procedures such as PCI and coronary artery bypass grafting are essential in managing CS caused by myocardial infarction[6]. Early revascularization can restore blood flow to the heart muscle and prevent further damage. Thirdly, the use of inotropes and vasopressors should be carefully titrated to avoid complications such as arrhythmias and excessive vasoconstriction[14]. Adequate fluid resuscitation is necessary to maintain blood pressure and cardiac output, but excessive fluid administration can lead to pulmonary edema and worsen CS[14]. Fourthly, mechanical circulatory support devices such as intra-aortic balloon pump (IABP) and extracorporeal membranous oxygenation (ECMO) may be necessary in refractory cases of CS[15]. However, these devices have risks and complications, such as bleeding and infection, which should be carefully monitored and managed[16]. Finally, closely monitoring hemodynamic parameters such as blood pressure, heart rate, and cardiac output is essential to guide management and assess response to therapy[16]. Patients with CS require close attention and frequent assessments to identify and manage any complications that may arise.

The management of patients with CS undergoing primary PCI has evolved significantly over the last few decades. Despite these advances, the mortality rate in this patient population remains high[17]. There is a need to identify factors associated with poor immediate outcomes after primary PCI in patients with CS to help identify high-risk patients and guide treatment decisions[13]. Understanding the predictors of mortality and other immediate outcomes after primary PCI in patients with CS can also provide valuable insights for further refining the management of these patients. Therefore, this study aimed to investigate the immediate mortality rate in patients with CS undergoing primary PCI and identify mortality predictors.

MATERIALS AND METHODS

This retrospective analysis was conducted at the largest tertiary care cardiac hospital in Karachi, Pakistan, after approval from the institutional ethical review committee (ERC/46/2022). For this analysis, the de-identified data were extracted from the hospital records for the consecutive patients with CS who underwent primary PCI at our institution between January 2018 and December 2022. Patients with missing information on study variables were excluded from the analysis, and patients who did not undergo primary PCI were also excluded.

The primary outcome was immediate mortality, defined as mortality within index hospitalization. Baseline demographics, clinical characteristics, and procedural data were collected. Data regarding the hospital course of the patients were also extracted, which included IABP placement, intubation, temporary pacemaker, inotropic support, and in-hospital complications such as sepsis, renal dysfunction, cardiac arrest, cerebrovascular accident, hypoxic brain injury, and multi-organ dysfunction.

Data regarding demographics, clinical characteristics, procedural, and hospital course were compared between the two groups of patients based on immediate survival status with the help of an independent sample t-test/Mann-Whitney U test or Chi-square test/Fisher exact test. Univariate and multivariable binary logistic regression analyses were performed to identify predictors of immediate mortality. All the variables withPvalue ＜ 0.20 in the univariate analysis were included in the multivariable analysis[18]. All the statistical analyses were formed with the help of IBM SPSS version 21, andP＜ 0.05 was the set criteria for statistical significance.

RESULTS

A total of 305 patients were included, of which 222 (72.8%) were male, and the mean age of the study sample was 58.1 ± 11.8 years. Most patients were in Killip class IV, 186 (61.0%), at the time of presentation. The immediate mortality rate was found to be 54.8% (167). The mean age was 59.4 ± 12.0vs56.5 ± 11.5;P= 0.031, Killip IV at presentation was 68.3%vs52.2%;P= 0.004, and diabetes was present in 54.5%vs41.3%;P= 0.022 among expired and survived patients, respectively (Table 1).

The multivessel disease was observed in 90.4%vs68.1%;P＜ 0.001, high thrombus burden (grade ≥ 4) in 85.6%vs67.4%;P＜ 0.001, bifurcations lesion in 29.9%vs16.7%;P= 0.007, intraluminal defect in 89.8%vs81.9%;P= 0.045, need of temporary pacemaker was for 60.5%vs1.4%;P＜ 0.001, need of intubation for 78.4%vs2.2%;P＜ 0.001, need of inotropic support was 76.0%vs1.4%;P＜ 0.001, need of IABP was 48.5%vs21.7%;P＜ 0.001, and left ventricular dysfunction was observed in 91.0%vs75.4%;P＜ 0.001 among expired and survived patients, respectively (Table 2).

Multivariate analysis identified Killip class IV at presentation [odds ratio (OR): 2.0; 95% confidence interval (CI): 1.2-3.4;P= 0.008], Multivessel disease (OR: 3.5; 95%CI: 1.8-6.9;P＜ 0.001), and high thrombus burden (OR: 2.6; 95%CI: 1.4-4.9;P= 0.003) as independent predictors of immediate mortality (Table 3).

A 12.0% (20/167) of the total deaths were deaths on the catheterization table. Cardiac arrest was the most common cause of death observed in 95.8% (160/167). Among other causes, renal failure was observed in 25.1% (42/167), multiorgan dysfunction in 19.8% (33/167), sepsis in 18.0% (30/167), hypoxic brain injury in 6.6% (11/167), and cerebrovascular accident in 0.6% (1/167) patient.

DISCUSSION

CS is a severe complication of AMI associated with low blood pressure, poor organ perfusion, and high mortality rates.Overall, primary PCI plays a crucial role in managing patients with CS by improving blood flow to the heart, restoring cardiac function, and reducing mortality rates. However, the success of primary PCI depends on several factors, including the timeliness of treatment, the skill and experience of the operators performing the procedure, and the patient's overall health status. Therefore, it is essential to identify high-risk patients and provide timely and appropriate treatment to achieve the best outcomes. Therefore, we conducted a retrospective analysis of 305 patients with CScomplicated AMI who had undergone primary PCI at our center. It has been observed the immediate mortality rate was unacceptably high at 54.8%, with cardiac arrest followed by renal failure, multi-organ dysfunction, sepsis, hypoxic brain injury, and cerebrovascular accident as a cause of mortality. In multivariable analysis, Killip class IV at presentation, multivessel disease, and high thrombus burden (grade ≥ 4) were identified as independent predictors of immediate mortality.

Table 1 Distribution of demographics and clinical characteristics patients with cardiogenic shock stratified by immediate outcome after primary percutaneous coronary intervention

Despite advancements in the therapeutic and technical management of CS, the rate of adverse events remains unacceptably high. Studies have reported varying mortality rates in-hospital, short-term, and long-term depending on the definition of CS and follow-up duration. Similar to our study, Hay?ro?luet al[5] surveyed 319 CS complicated STelevation myocardial infarction (STEMI) patients treated with primary PCI and reported a high in-hospital mortality rate of 61.3%. This study found several predictors of in-hospital mortality, including final thrombolysis in myocardial infarction flow, chronic kidney disease, left ventricular ejection fraction, tricuspid annular plane systolic excursion, blood urea nitrogen level, lactate level, and plasma glucose level. Similarly, other studies, including Wanget al[19] and Backhauset al[13], reported 65.3% and 37%-50% in-hospital mortality rates, respectively. The use of IABP has decreased over the years, and improvements in therapeutic management, such as increased use of drug-eluting stents, prasugrel, and ticagrelor, have resulted in better long-term prognosis for these patients[13]. Kawajiet al[20] conducted a registrybased study on 466 STEMI patients with CS and reported high 30-d, one-year, and five-year mortality rates of 25.4%,38.7%, and 51.4%, respectively.

Table 2 Distribution of angiographic and procedural characteristics patients with cardiogenic shock stratified by immediate outcome after primary percutaneous coronary intervention

Additionally, the identification of clinical predictors of mortality can help guide treatment decisions and improve patient outcomes. Our study identified Killip class IV at presentation, multivessel disease, and high thrombus burden (grade ≥ 4) as independent predictors of immediate mortality. Several clinical predictors of mortality in patients with CS have been identified in the literature, including age: Advanced age is a significant predictor of mortality in patients with CS[21]. Older patients have more comorbidities and are at higher risk of complications. The severity of shock: The degree of hemodynamic compromise, measured by the cardiac index, central venous pressure, and mean arterial pressure, is strongly associated with mortality[21]. AKI: AKI is a common complication in patients with CS and is associated with increased mortality[8]. Delayed revascularization: Delayed revascularization, defined as a time to revascularization of more than 24 h, is associated with increased mortality in patients with CS due to myocardial infarction[22]. Elevated lactate levels: Elevated lactate levels indicate tissue hypoxia and are a marker of poor prognosis in patients with CS[23]. Presence of comorbidities: Patients with preexisting comorbidities such as diabetes, hypertension, and chronic kidney disease have a higher risk of mortality[24]. Use of mechanical circulatory support: Mechanical circulatory support devices such as IABP and ECMO are associated with increased mortality, likely due to the severity of illness in patients requiring these interventions[25].

Further research is necessary to oversee and manage patients with STEMI complicated by CS. To achieve this, some researchers have proposed risk stratification scoring systems that have demonstrated good predictive value for the risk stratification of 30-d mortality[19,26,27]. Along with reperfusions, multidisciplinary management of CS patients is mandatory to improve outcomes. Several studies have reported a significant increase in the incidence of CS complicating STEMI, with one study reporting an incidence of 9% in 2006, which rose to 16% over ten years[13]. Similarly, an analysis of a United States nationwide database found that the incidence of STEMI complicated by CS increased from 6.5% to 10.1% between 2003 and 2010[28]. As a result, targeted research efforts are required to improve outcomes for these highrisk patients. While emergency revascularization of the culprit artery is the only proven effective method thus far, evidence for other supportive and medical therapies is unsatisfactory, and the use of IABP has shown no clinical benefit; however, the use of ECMO and Impella may yield better outcomes[29].

Certain limitations of the study need to be acknowledged. It was a single center-based retrospective study with a relatively small sample; hence, the generalizability of study findings may be limited.

CONCLUSION

In conclusion, immediate mortality rates in patients with CS undergoing primary PCI remain high despite advances in treatment strategies. Killip class IV at presentation, multivessel disease, and high thrombus burden (grade ≥ 4) were identified as independent predictors of immediate mortality. Such predictors can help guide treatment decisions and risk stratification in patients with CS. These findings underscore the need for aggressive management and close monitoring of patients with CS undergoing primary PCI, particularly those with these high-risk characteristics.

ARTICLE HIGHLIGHTS

Research background

Cardiogenic shock (CS) is a life-threatening complication of acute myocardial infarction with high morbidity and mortality rates.

Research motivation

The management of CS requires a multidisciplinary approach involving cardiology, critical care, and interventional teams. Early identification and diagnosis of CS is crucial, as early interventions have been shown to improve survival rates.

Research objectives

This study aimed to investigate the immediate mortality rates in patients with CS undergoing primary percutaneous coronary intervention (PCI) and identify mortality predictors.

Research methods

We conducted a retrospective analysis of 305 patients with CS who underwent primary PCI and immediate mortality rate was analyzed.

Research results

In a sample of 305 patients, the immediate mortality rate was found to be 54.8% with Killip class IV at presentation, multivessel disease, and high thrombus burden as independent predictors of immediate mortality.

Research conclusions

Immediate mortality rate in patients with CS undergoing primary PCI remains high despite advances in treatment strategies. Killip class IV at presentation, multivessel disease, and high thrombus burden (grade ≥ 4) were identified as independent predictors of immediate mortality.

Research perspectives

These findings underscore the need for aggressive management and close monitoring of patients with CS undergoing primary PCI, particularly in those with these high-risk characteristics.

ACKNOWLEDGEMENTS

The authors wish to acknowledge the support of the staff members of the Clinical Research Department of the National Institute of Cardiovascular Diseases (NICVD) Karachi, Pakistan.

FOOTNOTES

Author contributions:Solangi BA, Shah JA, Kumar R, Batra MK, Ali G, Butt MH, and Nisar A contributed to the concept and design of study; Saghir T, Sial JA, and Qamar N contributed to the analysis and interpretation of data; Solangi BA, Shah JA, Kumar R, Batra MK, Ali G, Nisar A, and Butt MH collected data and drafted the manuscript; Saghir T, Sial JA, and Qamar N critically analysed for content; All author approved the final draft of the manuscript.

Institutional review board statement:This study was reviewed and approved by the Ethics Committee of the National Institute of Cardiovascular Diseases (NICVD), Karachi.

Informed consent statement:Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.

Conflict-of-interest statement:All authors have no conflict of interest to disclose.

Data sharing statement:Data and material will be available upon request.

Open-Access:This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Country/Territory of origin:Pakistan

ORCID number:Bashir Ahmed Solangi 0000-0003-3090-7888.

S-Editor:Fan JR

L-Editor:A

P-Editor:Fan JR