亚洲免费av电影一区二区三区,日韩爱爱视频,51精品视频一区二区三区,91视频爱爱,日韩欧美在线播放视频,中文字幕少妇AV,亚洲电影中文字幕,久久久久亚洲av成人网址,久久综合视频网站,国产在线不卡免费播放

        ?

        Esophageal granular cell tumor: A case report

        2022-12-19 08:06:52YaLanChenJingZhouHuiLingYu
        World Journal of Clinical Cases 2022年19期

        Ya-Lan Chen,Jing Zhou,Hui-Ling Yu

        Abstract

        Key Words: Esophageal granular cell tumor; Esophagoscopy; Endoscopic mucosal resection; Immunohistochemical; Case report

        lNTRODUCTlON

        Granular cell tumor (GCT) is a rare disease that was first detected in the tongue by Abrikossoff in 1926[1]. Usually, GCT develops on the skin or oral mucosa, especially in the tongue[2]. In 1931, Abrikossoff first described GCT in the esophagus, which is currently the most common site of involvement within the gastrointestinal tract, primarily the distal segment of the esophagus[3]. Most esophageal granular cell tumor (eGCT) are benign, with fewer than 2% of clinical cases being malignant[4].

        In this report, we describe an eGCT that had developed in the middle of the esophagus, and we conducted a systematic review of 72 cases reported in China. The clinical data were analyzed to conclude the characteristics of eGCT so as to raise clinical awareness.

        CASE PRESENTATlON

        Chief complaints

        A 2-year history of acid reflux heartburn and a choking sensation during eating for the past month.

        History of present illness

        A 52-year-old female patient with a 2-year history of acid reflux heartburn and a choking sensation during eating for the past month was admitted to our hospital. Symptoms could be alleviated by oral administration of acid suppressants. We performed gastroscopy to establish the cause of the disease (June 2020). Upon admission, vital signs were within normal limits. Cardiopulmonary and abdominal examination did not show any abnormalities. Physical examination did not reveal a significant weight loss. There was no clinically significant family history, the patient had no smoking or drinking habits, and neither did she have a history of using special drugs or exposures to toxic substances.

        Under white light gastroscopy, there was a humulous-shaped eminence about 26 cm away from the incisor. Mucosa was smooth and clearly demarcated, with a size of about 0.4 cm and a hard yellow texture (Figure 1). Biopsy of the mass was performed. Pathological HE staining showed that tumor cells were closely arranged in a nest or strip shape, cell sizes were the same, the cytoplasm was rich, there was a large number of eosinophilic granulosa cells, while the nucleus was small, round and centered (Figure 2). The diagnosis of GCT was established by immunohistochemical staining, which was positive for the glycoprotein S100 protein, CK (+), SMA (-) (Figure 3).

        History of past illness

        The patient had an unremarkable medical history.

        Personal and family history

        There was no clinically significant family history, the patient had no smoking or drinking habits, and neither did she have a history of using special drugs or exposures to toxic substances.

        Physical examination

        Cardiopulmonary and abdominal examination did not show any abnormalities.

        Laboratory examinations

        No abnormality was found in blood routine examination and liver and kidney function. CEA, CA125 and CA199 were normal.

        Figure 1 Endoscopy of esophageal granular cell tumor.

        Figure 2 HE staining X200. The tumor cells were closely arranged in a cordlike pattern,

        Figure 3 lmmunohistochemical S100 positive. A: Contrast diagram not stained with S100; B and C: the nucleus and cytoplasm of granulosa cell tumor are brown and yellow by S-100 staining.

        Imaging examinations

        Under white light gastroscopy, there was a humulous-shaped eminence about 26 cm away from the incisor. Mucosa was smooth and clearly demarcated, with a size of about 0.4 cm and a hard yellow texture.

        FlNAL DlAGNOSlS

        Esophageal granular cell tumor.

        TREATMENT

        Because the volume of the mass was less than 1 cm, re-examination was performed by gastroscopy.

        OUTCOME AND FOLLOW-UP

        Her patient was diagnosed with granulosa cell tumor, but endoscopic surgery was not performed due to the small size of the tumor, and the tumor size did not increase during the 1-year follow-up.

        DlSCUSSlON

        The esophageal granular cell tumor is extremely uncommon. It was first described by Abrikossoff in 1931, when he reported on a patient with such tumors found in the esophagus. However, eGCT is an unusual developmental site for GCTs. Johnston and Helwig[3] reported on 75 GCTs of the gastrointestinal tract, most of them being located in the esophagus, which accounts for about 1 to 2 % of GCTs. Majority of these GCTs are often located in the esophageal distal part, followed by the colon, perianal region, stomach, small intestines and appendix[5].

        Recently, we conducted a literature search in PubMed, Web of Science, and China National Knowledge Infrastructure (CNKI) were searched for all studies published till July 2021. Using relevant keywords “esophageal granular cell tumor” in Chinese, and found 71 cases. The patient described in this report is the 72ndcase, which confirms that Esophageal GCTs are rare. Of the 72 patients, 44 were male while 28 were female, their ages ranged from 28 years to 66 years, with a mean of 46 years. Regarding clinical manifestations, 30 patients exhibited upper abdominal pain and fullness while 10 patients had swallowing discomforts, acid reflux and heartburn. Regarding esophageal location, they were in the upper (n= 9), middle (n= 18), and distal (n= 45) parts. Most of the tumors appeared yellow. Maximum diameters of tumors ranged from 0.4 cm to 5.5 cm, however, most of them were within 1 cm. A total of 35 patients had been subjected to endoscopic ultrasonography: 22 cases originated from the submucosa, 6 cases from the mucosal layer, 5 cases from the mucosal muscularis, and 2 cases from muscularis propria. One case of malignant granulosa cell tumor was pathologically confirmed (1.38%).

        Usually, eGCT, which is diagnosed by gastroscopy, clinically manifests as a slow-growing round tumor with somewhat undefined margins measuring between 5-20 mm in diameter[6]. It appears yellow or white, with a hard, fixed texture. Endoscopy can be performed to provide additional information on the layer of origin and tumor extension[7]. Most eGCTs originate from the submucosa, it doesn't invade serosal layers of the esophagus. Histologic evaluation is the gold standard method for diagnosis.

        Clinically, eGCT is a rare soft lesion with potential malignant tissue neoplasms. Its tissue origin is unclear. Various cell lines, derived from Schwann cells of the neuroectoderm have been proposed to be possible causes of GCT[8]. GCT exhibits typical pathomorphology and immunohistochemical characteristics. The main characteristics consist of nests of round or polygonal large cells with round, central nuclei and with eosinophilic cytoplasms as well as markedly enlarged lysosomes with a granular appearance[3]. Immunohistochemistry expressing S-100, CD68 and Vimentin, did not express CD117, CD34, SMA, Desmin, CK. Observation of these tumors is indicated unless the patient is symptomatic or the tumor is greater than 1 cm or has atypical endoscopic ultrasonographic or histologic features[7]. The most preferred treatment option for eGCT is endoscopic resection, which is highly associated with bleeding and perforation[9,10]. Although most granulocytomas are benign and grow slowly, about 2% of granulocytomas are malignant, which require surgery. For clinical evaluation, tumor diameter ≥ 3 cm is considered malignant, however, malignancy is also suspected if the tumor grows rapidly and forms ulcers[11]. The rapid growth of malignant tumors can lead to metastasis, especially to regional lymph nodes, lungs, liver, and bone[12].

        CONCLUSlON

        In conclusion, the gastro- intestinal tract is an unusual developmental site for a GCTs, with the esophagus being the most common site of origin. Its diagnosis depends on characteristic pathomorphologies and detection of the S-100 protein. Endoscopic mucosal resection is the preferred therapeutic method.

        ACKNOWLEDGEMENTS

        We sincerely thank the patient and their family for their support and dedication.

        FOOTNOTES

        Author contributions:Chen YL wrote the initial draft and drafted the data and figures; Yu HL revised the draft; Zhou J provided clinical supervision and edited the manuscript; All authors approved the final version of the manuscript.

        lnformed consent statement:The study participant provided informed written consent prior to the study.

        Conflict-of-interest statement:The authors declare that there are no conflicts of interest.

        CARE Checklist (2016) statement:The article is consistent for CARE Checklist (2016) statemen.

        Open-Access:This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BYNC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is noncommercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

        Country/Territory of origin:China

        ORClD number:Ya-Lan Chen 0000-0002-0680-8006; Jing Zhou 0000-0002-8876-195X; Hui-Ling Yu 0000-0002-5476-5661.

        S-Editor:Ma YJ

        L-Editor:Filipodia

        P-Editor:Ma YJ

        国产av午夜精品一区二区入口| 精品国产制服丝袜高跟| 国产在线91观看免费观看| 国产免费激情小视频在线观看| 日本一区二区三级在线| 成在线人av免费无码高潮喷水| a级毛片毛片免费观看久潮喷| 亚洲精品成人国产av| av一区二区三区观看| 国产a∨天天免费观看美女| 日日碰狠狠添天天爽超碰97| 国产精品一区二区三区精品| 一区二区三区在线乱码| 97久久婷婷五月综合色d啪蜜芽| 中国凸偷窥xxxx自由视频| 亚洲精品美女自拍偷拍| 中文字幕视频一区懂色| 91精品福利一区二区三区| 亚洲深深色噜噜狠狠网站| 亚洲国产日韩欧美一区二区三区| 亚州精品无码人妻久久| 国内精品九九久久精品小草| 中文字幕乱码亚洲一区二区三区 | 亚洲一区二区三区高清视频| 国产亚洲av无码av男人的天堂| 熟妇的荡欲色综合亚洲| 无码一区二区三区网站| 日本视频在线播放一区二区| 久久国产色av免费观看| 野外少妇愉情中文字幕| 狠狠色婷婷久久一区二区| 国产一区二区精品网站看黄| 中文字幕一区久久精品| 蜜桃视频一区二区在线观看| 亚洲色国产欧美日韩| 无码 制服 丝袜 国产 另类| 国产视频一区二区三区免费| 久久国产精品亚洲va麻豆| 国产精品无码一本二本三本色| 91亚洲国产成人aⅴ毛片大全| 亚洲三区av在线播放|