亚洲免费av电影一区二区三区,日韩爱爱视频,51精品视频一区二区三区,91视频爱爱,日韩欧美在线播放视频,中文字幕少妇AV,亚洲电影中文字幕,久久久久亚洲av成人网址,久久综合视频网站,国产在线不卡免费播放

        ?

        HRG-9 homologues regulate haem trafficking from haem-enriched compartments

        2022-12-06 05:30:46FengxiuSunetal
        四川生理科學(xué)雜志 2022年10期

        Fengxiu Sun,et al.

        Haem is an iron-containing tetrapyrrole that is critical for a variety of cellular and physiological processes1-3.Haem binding proteins are present in almost all cellular compartments,but the molecular mechanisms that regulate the transport and use of haem within the cell remain poorly understood2,3.Here we show that haem-responsive gene 9 (HRG-9) (also known as transport and Golgi organization 2 (TANGO2)) is an evolutionarily conserved haem chaperone with a crucial role in trafficking haem out of haem storage or synthesis sites in eukaryotic cells.Loss of Caenorhabditis elegans hrg-9 and its paralogue hrg-10 results in the accumulation of haem in lysosome-related organelles,the haem storage site in worms.Similarly,deletion of the hrg-9 homologue TANGO2 in yeast and mammalian cells induces haem overload in mitochondria,the site of haem synthesis.We demonstrate that TANGO2 binds haem and transfers it from cellular membranes to apo-haemoproteins.Notably,homozygous tango2-/-zebrafish larvae develop pleiotropic symptoms including encephalopathy,cardiac arrhythmia and myopathy,and die during early development.These defects partially resemble the symptoms of human TANGO2-related metabolic encephalopathy and arrhythmias,a hereditary disease caused by mutations in TANGO24-8.Thus,the identification of HRG-9 as an intracellular haem chaperone provides a biological basis for exploring the aetiology and treatment of TANGO2-related disorders.

        亚洲精品夜夜夜| 色欲色香天天天综合vvv| 国产伦理一区二区| 四虎影院在线观看| 香蕉久久夜色精品国产| 久久99人妖视频国产| 亚洲av国产av综合av卡| 国产精品亚洲综合色区韩国| 国产乱人视频在线观看播放器| 亚洲狠狠久久五月婷婷| 国产一区二区精品久久岳| 伦人伦xxxx国语对白| 久久夜色精品国产噜噜噜亚洲av | 欧美大黑帍在线播放| 欧美乱人伦中文字幕在线不卡| 国产成人亚洲精品一区二区三区| 大地资源网在线观看免费官网| 福利体验试看120秒| 日韩av一区二区三区四区av| 久久熟女少妇一区二区三区| 欧美做受又硬又粗又大视频| 永久免费av无码网站性色av| 91情侣在线精品国产免费| 91盗摄偷拍一区二区三区| 欧美成妇人吹潮在线播放| 无码中文字幕在线DVD| 精品久久日产国产一区| 男女无遮挡高清性视频| 精品国模一区二区三区| 久久国产精品免费一区二区| 亚洲av日韩综合一区尤物| 日韩av激情在线观看| 久久AⅤ无码精品为人妻系列| 日本草逼视频免费观看| 久久综合精品人妻一区二区三区| 无码日韩精品一区二区三区免费| 精品国产亚欧无码久久久| 你懂的视频网站亚洲视频| 五月丁香综合激情六月久久| av鲁丝一区鲁丝二区| 在线观看国产av一区二区|