亚洲免费av电影一区二区三区,日韩爱爱视频,51精品视频一区二区三区,91视频爱爱,日韩欧美在线播放视频,中文字幕少妇AV,亚洲电影中文字幕,久久久久亚洲av成人网址,久久综合视频网站,国产在线不卡免费播放

        ?

        HRG-9 homologues regulate haem trafficking from haem-enriched compartments

        2022-12-06 05:30:46FengxiuSunetal
        四川生理科學(xué)雜志 2022年10期

        Fengxiu Sun,et al.

        Haem is an iron-containing tetrapyrrole that is critical for a variety of cellular and physiological processes1-3.Haem binding proteins are present in almost all cellular compartments,but the molecular mechanisms that regulate the transport and use of haem within the cell remain poorly understood2,3.Here we show that haem-responsive gene 9 (HRG-9) (also known as transport and Golgi organization 2 (TANGO2)) is an evolutionarily conserved haem chaperone with a crucial role in trafficking haem out of haem storage or synthesis sites in eukaryotic cells.Loss of Caenorhabditis elegans hrg-9 and its paralogue hrg-10 results in the accumulation of haem in lysosome-related organelles,the haem storage site in worms.Similarly,deletion of the hrg-9 homologue TANGO2 in yeast and mammalian cells induces haem overload in mitochondria,the site of haem synthesis.We demonstrate that TANGO2 binds haem and transfers it from cellular membranes to apo-haemoproteins.Notably,homozygous tango2-/-zebrafish larvae develop pleiotropic symptoms including encephalopathy,cardiac arrhythmia and myopathy,and die during early development.These defects partially resemble the symptoms of human TANGO2-related metabolic encephalopathy and arrhythmias,a hereditary disease caused by mutations in TANGO24-8.Thus,the identification of HRG-9 as an intracellular haem chaperone provides a biological basis for exploring the aetiology and treatment of TANGO2-related disorders.

        日本免费看片一区二区三区| 欧美一欧美一区二三区性| 国产成人av在线影院无毒| 国产av精品久久一区二区| 亚洲av熟女少妇久久| 天堂无码人妻精品av一区| 精品无码人妻夜人多侵犯18| 成人三级a视频在线观看| 国产精品久久无码不卡黑寡妇| 人妻免费黄色片手机版| 国产精品午夜夜伦鲁鲁| 亚洲精品国产suv一区88| 水蜜桃久久| 国产精品三级自产拍av| 99e99精选视频在线观看| 精品水蜜桃久久久久久久| 青草网在线观看| 免费视频一区二区三区美女| 粉嫩av国产一区二区三区| 国产69精品久久久久9999| 亚洲高清精品50路| 男女激情视频网站在线| 天天爽夜夜爽人人爽一区二区 | 女同性黄网aaaaa片| 99精品国产第一福利网站| 亚洲男同免费视频网站| 天天摸夜夜摸摸到高潮| 婷婷成人亚洲| 在线精品亚洲一区二区三区 | 人人添人人澡人人澡人人人人 | 美女福利视频网址导航| 亚洲熟妇av一区二区三区| 亚洲欧美日韩精品久久亚洲区| 国产亚洲精品综合在线网址| 人妻少妇av中文字幕乱码| 日产亚洲一区二区三区| 亚洲AV无码国产永久播放蜜芽| 国产成人亚洲精品一区二区三区| 婷婷伊人久久大香线蕉av| 亚洲成人小说| av免费看网站在线观看|