亚洲免费av电影一区二区三区,日韩爱爱视频,51精品视频一区二区三区,91视频爱爱,日韩欧美在线播放视频,中文字幕少妇AV,亚洲电影中文字幕,久久久久亚洲av成人网址,久久综合视频网站,国产在线不卡免费播放

        ?

        HRG-9 homologues regulate haem trafficking from haem-enriched compartments

        2022-12-06 05:30:46FengxiuSunetal
        四川生理科學(xué)雜志 2022年10期

        Fengxiu Sun,et al.

        Haem is an iron-containing tetrapyrrole that is critical for a variety of cellular and physiological processes1-3.Haem binding proteins are present in almost all cellular compartments,but the molecular mechanisms that regulate the transport and use of haem within the cell remain poorly understood2,3.Here we show that haem-responsive gene 9 (HRG-9) (also known as transport and Golgi organization 2 (TANGO2)) is an evolutionarily conserved haem chaperone with a crucial role in trafficking haem out of haem storage or synthesis sites in eukaryotic cells.Loss of Caenorhabditis elegans hrg-9 and its paralogue hrg-10 results in the accumulation of haem in lysosome-related organelles,the haem storage site in worms.Similarly,deletion of the hrg-9 homologue TANGO2 in yeast and mammalian cells induces haem overload in mitochondria,the site of haem synthesis.We demonstrate that TANGO2 binds haem and transfers it from cellular membranes to apo-haemoproteins.Notably,homozygous tango2-/-zebrafish larvae develop pleiotropic symptoms including encephalopathy,cardiac arrhythmia and myopathy,and die during early development.These defects partially resemble the symptoms of human TANGO2-related metabolic encephalopathy and arrhythmias,a hereditary disease caused by mutations in TANGO24-8.Thus,the identification of HRG-9 as an intracellular haem chaperone provides a biological basis for exploring the aetiology and treatment of TANGO2-related disorders.

        国产免费人成视频网站在线18| 精品亚洲女同一区二区| 99精品国产av一区二区| 国产视频激情在线观看| 国产97在线 | 日韩| 欧美亚洲精品一区二区| 亚洲国产精品综合福利专区| 午夜少妇高潮在线观看视频| 日本天堂免费观看| 亚洲av永久无码一区| 国产丰满乱子伦无码专| 一本色道久久88加勒比| 日本护士xxxx视频| 久久AV老司机精品网站导航| 国产伪娘人妖在线观看| 中文字幕一区在线直播| 日韩欧美人妻一区二区三区| 久久久久久人妻精品一区百度网盘 | 国产成人v爽在线免播放观看| 国产三级在线观看性色av| 亚洲综合自拍偷拍一区| 日本黄网站三级三级三级 | 91精品欧美综合在线观看| 综合久久精品亚洲天堂| 手机福利视频| 99在线精品国产不卡在线观看 | 日本视频一区二区三区在线| 熟妇熟女乱妇乱女网站| 欧美人与物videos另类xxxxx| 久久午夜伦鲁鲁片免费| 91自拍视频国产精品| 亚洲精品午睡沙发系列| 亚洲欧美在线视频| 中文乱码字幕在线亚洲av| 天堂网www资源在线| 最新国产乱视频伦在线| 亚洲天堂一区二区精品| 亚洲av男人电影天堂热app| 3344永久在线观看视频| 日本一区二区三区资源视频| 日本在线一区二区三区不卡|