Semra Demirli Atici,Erdinc Kamer

Semra Demirli Atici,Erdinc Kamer,Department of General Surgery,University of Health Sciences Tepecik Training and Research Hospital,?zmir 35180,Turkey

Abstract Postoperative morbidity and mortality rates are still very high among patients undergoing pancreaticoduodenectomy(PD).However,mortality rates secondary to morbidities that are detected early and well-managed postoperatively are lower among patients undergoing PD.Since early detection of complications plays a very important role in the management of these patients,many ongoing studies are being conducted on this subject.Recent endoscopic retrograde cholangiopancreatography and biliary drainage history of the patient study group is important for comparison of C-reactive protein(CRP),an inflammatory parameter evaluated in the retrospective study by Coppola et al published in the World Journal of Gastrointestinal Surgery and titled “Utility of preoperative systemic inflammatory biomarkers in predicting postoperative complications after pancreaticoduodenectomy:Literature review and single center experience”.Therefore,it may be more appropriate to compare CRP values in randomized patients.

Key Words:Pancreaticoduodenectomy;Biliary drainage;Complications;C-reactive protein;CRP;Postoperative pancreatic fistula;Preoperative inflammatory markers

TO THE EDITOR

Coppolaet al[1]recently published a retrospective study on the role of preoperative inflammatory markers to detect the predictive efficiency of postoperative morbidity and mortality in pancreaticoduodenectomy(PD)patients.

Most patients diagnosed with pancreatic cancer undergo preoperative endoscopic retrograde cholangiopancreatography(ERCP)for diagnostic purposes.Preoperative biliary drainage(PBD)can be performed in addition to ERCP in these patients,who may also present with the complaint of obstructive jaundice[2].

PBD itself,duration of the PBD and the ERCP procedure can each increase the inflammatory response[3,4].Coppolaet al[1]found that preoperative C-reactive protein(CRP)level of ＞ 8.81 mg/dL was a high-risk factor for general complications and abdominal collection,which was associated with the inflammatory parameters examined prior to PD operations.Unfortunately,the authors did not report the number of PBD procedures performed on the individual patients included in their study,nor did they provide information on the duration of time before the ERCP procedure was performed for any.This missing information may preclude our ability to make conclusions on the effectiveness of the baseline CRP value,since the recent history of ERCP and the history of PBD are unknown for the study’s patients.A history of PBD will cause an increased inflammatory response.In addition,increased postoperative complication rates have been demonstrated in relation to a history of PBD and duration of biliary drainage.Prospective randomized controlled trials would be more instructive in determining the efficacy of preoperative inflammatory markers and their importance in the rates of postoperative complications due to PD.

FOOTNOTES

Author contributions:Demirli Atici S and Kamer E wrote the manuscript;Kamer E reviewed and supervised the manuscript preparation;Both authors read and agreed to the published version of the manuscript.

Conflict-of-interest statement:The authors declare having no potential conflicts of interest with respect to the research,authorship and/or publication of this article.

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Country/Territory of origin:Turkey

ORCID number:Semra Demirli Atici 0000-0002-8287-067X;Erdinc Kamer 0000-0002-5084-5867.

Corresponding Author's Membership in Professional Societies:Association of Surgeons of Great Britain &Ireland(ASGBI);Association of Coloproctology of Great Britain and Ireland(ACPGBI).

S-Editor:Wu YXJ

L-Editor:A

P-Editor:Wu YXJ