TO THE EDITOR

I read the important retrospective study by Kapur[1] on the risk of methicillin-resistant(MRSA) prosthetic joint infection in elective total hip and knee arthroplasty following eradication therapy.MRSA is a virulent pathogen that causes infections among healthy and immunocompromised individuals.The spectrum of MRSA infection varies from cellulitis,necrotizing fasciitis,bone and joint infections,bacteremia,and infective endocarditis to pneumonia[2].

That article provides a crucial insight into the importance of screening and re-screening following eradication of MRSA prior to prosthetic joint implant in orthopedic surgery.The authors have compared the incidence of prosthetic joint infection (PJI) among MRSA colonizers and non-colonizers,and following follow-up,found that PJI risk is high among MRSA colonizers.As we know,the associated financial burden following PJI is substantial.

The authors have mentioned the method of MRSA decolonization and some practice instead of prontoderm nasal spray and octenisan for 4% chlorhexidine and mupirocin ointment.The IDSA guidelines explain the importance of the latter regime,but different formulae have similar decolonization ability and differ in cost as the latter is cheaper[3].Use of povidone-iodine and rifampin has shown efficient and low cost MRSA decolonization.Simor[4] showed that the use of topical germicide and antibiotic plus oral agents and rifampin achieved a 92% eradication rate for MRSA.Moreover,the duration of decolonization was given as 5-10 d of mupirocin and 5-14 d of 4% chlorhexidine body wash.Here the authors have discussed the mupirocin use.

And true to his word, that little elf began to do Patrick s homework. Except there was one glitch4. The elf didn t always know what to do and he needed help. Help me! Help me! he d say. And Patrick would have to help -- in whatever way.

The authors mentioned the use of teicoplanin prophylaxis among MRSA positive patients.In emergency surgery,the advice is to provide vancomycin or teicoplanin prophylactically while replacing cefuroxime.However,routine use of anti-MRSA antibiotic prophylaxis for MRSA positives following decolonization is questionable.The expectation would be to minimize the occurrence of MRSA bacteremia.Most studies have discussed the failure of the MRSA decolonization procedure.Almost all prosthetic joint implantation is done as a planned procedure;this would signify the importance of employing the re-screening strategy following decolonization prior to the surgery[5].

The authors have highlighted the importance of re-screening while relating the financial and social burden following PJI.Another thing is that,if possible,re-screening following MRSA eradication would minimize the prophylactic use of teicoplanin.

A study conducted by Garvey[6] showed the possibility of having MRSA colonization following decolonization.Following repeated decolonization,the MRSA colonization has been reduced from 7.2% to 4.7%.Several methods were employed by different research groups for MRSA screening.In addition to molecular methods,the use of chromogenic agar is also costly,but the use of mannitol salt agar and swabs into 7.5% NaCl in brain-heart infusion broth and phenotypic detection including tube and slide coagulase testing is cost effective to isolate MRSA[2].Over the period,I have seen many patients with repeated MRSA colonization following MRSA decolonization.However,almost all isolates were mupirocin susceptible.Therefore,it may be associated with a lack of compliance and a lack of highlighting the importance of decolonization to the patient or the family.Since most patients are morbid and probably have mobility problems,adherence to a 5-d regular body wash and nasal spraying is questionable[7].

Re-screening following MRSA decolonization will be helpful to minimize the development of PJI among MRSA colonizers.

“I wished that you and Grandma could have church. And I just knew that it would come true. Look! There’s the pastor, and everyone from church is coming up the walk.”

Now memories of the past flash through my headAnd the pain is obvious by the tears that I shed2.I ask myself why and where I went wrongI guess I was weak when I had to be strong.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers.It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BYNC 4.0) license,which permits others to distribute,remix,adapt,build upon this work non-commercially,and license their derivative works on different terms,provided the original work is properly cited and the use is noncommercial.See: https://creativecommons.org/Licenses/by-nc/4.0/

“Yes, listen,” replied the crow, “but it is so difficult to speak your language. If you understand the crows’ language then I can explain it better. Do you?”

All the authors declare that they have no conflict of interest to disclose.

Sampath Jayaweera JAA designed the study,analyzed the data,and wrote the manuscript.

Sri Lanka

Jayaweera Arachchige Asela Sampath Jayaweera 0000-0001-5051-530X.

Liu JH

27. Not dreaming after what manner she should dress them: The French verb habiller can mean, as in English, to put on clothing or to clean and truss, making this a rare instance in which a pun or double entendre translates successfully across two languages (Larousse, p. 490).Return to place in story.

Wang TQ

Liu JH