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        Corrigendum to“The effective transfection of a low dose of negatively charged drug-loaded DNA-nanocarriers into cancer cells via scavenger receptors”[Journal of Pharmaceutical Analysis volume 11 (2021)174-182]

        2022-09-23 04:12:36MirzMuhmmFrnAshrfBigChngfiZhngMuhmmFurqnAkhtrAmmrSlmJhnzbMussir
        Journal of Pharmaceutical Analysis 2022年4期

        Mirz Muhmm Frn Ashrf Big ,Chngfi Zhng ,Muhmm Furqn Akhtr ,Ammr Slm ,Jhnzb Mussir

        a Laboratory of Biomedical & Pharmaceutical Engineering of Stem Cells Research,Restorative Dental Sciences,Faculty of Dentistry,The University of Hong Kong,Hong Kong,999077,PR China

        b State Key Laboratory of Analytical Chemistry for Life Sciences,School of Chemistry and Chemical Engineering,Nanjing University,Nanjing,210023,PR China

        c Faculty of Pharmacy,Bahauddin Zakariya University,Multan 60000,Pakistan

        d Riphah Institute of Pharmaceutical Sciences,Riphah International University,Lahore,Pakistan

        e Department of Pharmacology,Faculty of Pharmaceutical Sciences,Government College University Faisalabad,Faisalabad,Pakistan

        The authors regret to inform that Figs.4,6,and 7 in the original article were wrongly selected.The corrected figures appear below:The authors would like to apologize for any inconvenience caused.

        Fig.4.AFM and confocal characterization of DNA-NWs.(A) AFM imaging of DNA-NWs.(B) Confocal imaging of FITC-tagged CPT-loaded DNA-NWs.

        Fig.6.Biocompatibility and cytotoxicity assay of blank and CPT-loaded DNA-NW.MTT assay of(A)biocompatibility of blank DNA-NWs and(B)cytotoxicity of CPT-loaded DNA-NWs compared with equivalent concentrations of free CPT solution.(C) Flow cytometry assessment of the biocompatibility of blank solution,DNA-NW solution,and the cytotoxicity of CPT-loaded DNA-NW.

        Fig.7.Surface binding of DNA-NW loaded with FITC-tagged CPT to the human liver cancer cell line (HepG2) compared with the control cell line (CHSE-214) derived from the salmon embryo after a 30 min interval.(A) As HepG2 cells are rich in scavenger receptors,DNA-NW binds the cell surfaces followed by gradual internalization into the cells and release of FITC-tagged CPT into the cytoplasm.(B)As CHSE-214 cells lack scavenger receptors,DNA-NW could not bind these cells effectively,resulting in inferior cell internalization.

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