INTRODUCTION

3)行、蓄、滯洪區(qū)：1∶250 000比例尺上圖上面積大于1 cm2的一般應(yīng)表示。當(dāng)范圍線與等高線重合時(shí)，可壓蓋等高線表示[2]。

In Europe, data is available regarding the prevalence of refractive errors in different countries (

, France,Denmark, the Netherlands, Norway, Northern Ireland, and the United Kingdom)

; however, only a few studies show the novel increase of the prevalence of myopia in younger age groups

. The estimated prevalence of myopia [-0.5 dioptres (D) or less] throughout Central Europe was 34.6% in 2020, and is expected to increase to 54.1% by 2050

.

In Hungary, very few studies were published on the prevalence of refractive errors. In 1934, based on the examination of 8860 schoolchildren (aged between 4 and 18y) in Budapest,emmetropia was found in 24.8% and 20.1%, hyperopia in 50.0% and 50.5%, and myopia in 7.0% and 6.5%, of boys and girls, respectively

. The prevalence of myopia increased parallel with age: it was 2.0% among 6-10 years old and 2.5%among 10-14 years old. Above these ages, it increased to a larger extent: in 15 year-old it was 6.0%, in 16-year-old 7.9%,in 17-year-old 12.0%, and in 18-year-old 10.6%. The authors stated in the discussion that the prevalence of myopia in Budapest was far lower than the reported data from other large towns in Germany or Austria

. In 1960, among 48 020 persons evaluated at a regional eye examination centre in Budapest,22.10% had hyperopia or presbyopia, and 4.73% had myopia.The data were skewed toward younger age groups, due to the age composition of the sample (0-20y: 37.53%, 21-40y:19.97%, 41-60y: 28.92%, and 61+ years: 13.58%)

.In the present manuscript, we present data on the prevalence of refractive errors in different age groups among the population of Hungary, and on the increase of myopia in younger age groups. The data has been retrieved from the database of the nationwide general health screening campaign

.

SUBJECTS AND METHODS

檢測(cè)活動(dòng)在技術(shù)負(fù)責(zé)人和質(zhì)量監(jiān)督員的監(jiān)督下，檢測(cè)人員能依據(jù)《NY/T 761-2008 蔬菜和水果中有機(jī)磷、有機(jī)氯、擬除蟲菊酯和氨基甲酸酯類農(nóng)藥多殘留的測(cè)定》標(biāo)準(zhǔn)，按照農(nóng)藥組分出峰時(shí)間和峰面積分別檢測(cè)出在盲樣中添加的敵敵畏、氧化樂果、甲基對(duì)硫磷、乙烯菌核利、聯(lián)苯菊酯和氯氰菊酯、氰戊菊酯共7種農(nóng)藥，并能計(jì)算出各種農(nóng)藥組分的含量，較好地掌握了農(nóng)藥殘留檢測(cè)分析技術(shù)。

Analysing the results of the refractive measurements obtained from the Comprehensive Health Screening Program of Hungary, 2010-2020, refractive errors were found in the right eye of 60.0% of all participants (62.1% in women and 57.5%in men). Data on the left eyes showed similar results. The distribution of refractive errors, calculated using the spherical equivalents of the right eye of all participants, is shown in Figure 2. The relative distribution of SE refractive errors was as follows: hyperopia, 16.50%; emmetropia, 40.05%; low myopia, 43.24%; and high myopia, 0.21%. The proportion of myopia was the same in women and men (low myopia, 43.1%and 43.4%, and high myopia, 0.2% and 0.2%, respectively).However, hyperopia was more frequent among women than men (18.8%

14.0%, respectively), while emmetropia was less frequent among women than men (37.9%

42.5%,respectively).

The nationwide Comprehensive Health Screening Program of Hungary, 2010-2020, included eye examinations and provided autorefractometry data for 68 227 people aged 18 and older, who participated in the nationwide screening program between 2014 and 2019

. The inclusion of participants was voluntary. Among the participants, there were 35 850 women(52.5%) and 32 377 men (47.5%). To analyse the distribution of refractive errors throughout the different age groups, the entire population was subdivided into 12 age groups (18-25,26-30, 31-35, 36-40, 41-45, 46-50, 51-55, 56-60, 61-65, 66-70, 71-75, and 76+ years). The distribution of the population in each age group is shown in Figure 1. The distribution of age and sex in the sample population was similar to the national demographic distributions of 18 to 99 years old, but the 26-45 years old age group in both sexes was somewhat overrepresented in the sample, while the 61 and older age group was underrepresented

.

The results were presented as the relative prevalence of the various refractive errors, and the statistical difference in the prevalence of myopia by age group was calculated using the Chi-square test, while the increased prevalence of high myopia with increasing age was calculated using the Pearson correlation test.

We found a higher prevalence of myopia in those 76y and older than in those in the 51-75y range. This difference may be due to the well-known effects of nuclear sclerosis of the lens,and also to the fact that many of those 76y or older in Hungary had already undergone cataract surgery, with a typical outcome target refraction between 0 to -1 D. We know from our previous Rapid Assessment of Avoidable Blindness (RAAB)study that 25.1% of the 75y and older Hungarian population have already undergone cataract surgery with intraocular lens implantation

. In this same age group in a French study by Montrachet

, the crude prevalence of myopia increased with age, and was found to be higher in pseudophakic (40%-50%)than in phakic eyes (23%-32%), while hyperopia was far lower in pseudophakic than phakic eyes (9%-16%

49%-59%,respectively)

.

The National Public Health and Medical Officer Service approved (operating license number: áNTSZ 2380-5/2010)the Comprehensive Health Screening Program of Hungary,2010-2020. The data collected did not include any personal identification information, and the participants volunteered to participate in the screening examinations with implied consent.

RESULTS

Refraction measurements were performed without pupillary dilatation, using a PRK-6000 Auto Ref-Keratometer (Potec,Daejeon, Korea), which was calibrated every 4mo. The refractometer performed 3 automated measurements on each eye, and calculated an unweighted arithmetic mean for each parameter. The instrument indexed the measurement accuracy,being set to indicate an error for a scatter greater than 0.25 D and to request a repeat measurement. The mean spherical and cylindrical refraction of both eyes were entered into an electronic data table, based on which spherical equivalents(SE) were calculated (SE=spherical refraction+0.5×cylindrical refraction). Refractive errors were classified into 3 types:hyperopia (SE≥+0.5 D), low myopia (SE≤-0.5 D but ＞-6.0 D),and high myopia (SE≤-6.0 D). Emmetropia was defined as SE＜+0.5 D but ＞-0.5 D. Visual acuity was not measured during the collection of this data.

Data regarding the distribution of the refractive errors of individuals in various age groups show that myopia is 3 times more frequent in younger age groups (between 18 and 35y of age, relative prevalence of 58.7%) than in the older ones(56-70y, 19.4%; Chi-square=4364.646,

＜0.001), and that hyperopia is more frequent in the older age groups (49.4%) than in the younger ones (3.3%; Chi-square =10 903.98,

＜0.001), as seen in Figure 3. The relative prevalence of myopia increased over the age of 71y, while hyperopia decreased. High myopia was least prevalent (0.1%) in the 18-25 year-old group, which increased to 0.3% in the age groups between 46 and 65y,and then again up to 1.0% in those 75y and older (Pearson correlation,

=0.716;

=0.009).

DISCUSSION

The results of our survey showed that a high number of individuals in Hungary have refractive errors (60%), of which myopia was the most frequent refractive error in both sexes,affecting 43% of the adult Hungarian population. Myopia was found to be 2.6 times more frequent than hyperopia.

體育小鎮(zhèn)的空間布局受居民體育旅游需求以及體育旅游資源的吸引定向性等主客觀因素的影響[8]。因此，體育小鎮(zhèn)的空間布局需要考慮居民體育旅游的多樣性偏好、出游半徑以及出游成本等方面的因素，在空間布局過程中，應(yīng)避免某一區(qū)域同類型體育小鎮(zhèn)的重復(fù)建設(shè)，從異質(zhì)性的角度出發(fā)，差異化布局，實(shí)現(xiàn)體育小鎮(zhèn)優(yōu)勢(shì)互補(bǔ)。以環(huán)太湖體育圈為例，作為體育小鎮(zhèn)空間布局的軸線，環(huán)太湖體育旅游資源有一定的相似性，在后續(xù)體育小鎮(zhèn)的建設(shè)中，應(yīng)發(fā)揮地域特色優(yōu)勢(shì)，如蘇州漁洋山飛行傘訓(xùn)練基地、宜興湖父鎮(zhèn)竹海風(fēng)景區(qū)等可依據(jù)特色體育項(xiàng)目開展體育小鎮(zhèn)建設(shè)。

The European Eye Epidemiology Consortium found in their meta-analysis that the most frequent refractive error between 1990 and 2003 in the European population, aged 25-90y, was low myopia (30.6%), closely followed by hyperopia (25.2%),and then high myopia (2.7%)

. Our results showed a higher prevalence of low myopia, but a lower prevalence of high myopia and hyperopia. The disparity concerning low myopia might be due to the different definitions of refractive errors(non-cycloplegic SE defined as ≤-0.75 D

≤-0.5 D); however,it might be also due to the increase of myopia and associated decrease of hyperopia in the younger age groups, taking into account the approximately 15-year difference in the data sampling between their analysis and ours. The UK Biobank Study

exhibited a lower prevalence of myopia (26.6%)based on their resource database of people aged 40-69y, which is, however, similar to the prevalence of myopia found in our study in similar age groups.

Refractive errors are a significant cause of vision impairments worldwide, due to its associated ocular diseases and incorrect or absent corrections

. Myopia is one of the leading refractive errors worldwide, particularly in Chinese populations, but also among white populations as well

. In a review of 145 studies, Holden

estimated that globally, there are 1406 million people with myopia(22.9% of the worldwide population) and 163 million people with high myopia (2.7% of the world population), and predicted a 3.4-fold increase in myopia and a 5.8-fold increase in high myopia by 2050. These estimates show the importance of developing and introducing preventive measures and the precise clinical management of myopia

.

Significant geographical differences, however, have also been reported from Europe

. A study of Norwegian adolescents found a completely different distribution than we found in the present study, which in fact seem to defy worldwide trends. That study found that in 16-19 year-old Norwegian individuals, the prevalence of myopia and hyperopia was 12.7%and 56.7%, respectively

. In another study in Norway, the general population exhibited a higher prevalence of myopia (SE≤-0.25 D,33%)

. These lower prevalences of myopia might be due to a potentially delayed onset of myopia compared to other parts of Europe and East-Asia

. Among university students,however, an even higher prevalence of myopia (46.9%)and lower prevalence of hyperopia were found (29.5%)

.Fledelius

found a similarly high (50.0%) prevalence of myopia (SE≤-0.5 D) among medical students (median age,26y) in Denmark, with no obvious trend of an increasing prevalence of academic myopia, despite an increasing prevalence in the overall population. A study in the UK, which focused on younger white adults, 18-20y of age, found a lower prevalence both of myopia (18.6%) and hyperopia (17.7%),but did note a significant increasing tendency of myopia

.A study in Israel found a relatively low prevalence of myopia among 16-19-year-old, but noted a 1.3-fold increase in those over 24y of age, from 20.4 to 26.2%, respectively

.

In France, the highest prevalence of myopia was also found in the age groups between 10-39y of age, with a similarly high peak for the prevalence of myopia in those aged 20-29y, which was 52.4%

. The European Eye Epidemiology Consortium also found higher rates of myopia (SE≤-0.75 D) in younger age groups around 40%), and higher rates of hyperopia(SE≥1.0 D, around 55%) in those older than 50y of age

.When comparing our results with previous data

, we found a similar prevalence of hyperopia in older age groups; however,we found a higher prevalence of myopia in younger age groups, which may be due to the increasing myopia epidemics in younger individuals.

Another important finding from the present review was that the prevalence of myopia was 3 times higher (57%-61%) in younger age groups (18-35y of age) than in older ones (18%-20%, 56-70y of age). There may be at least two reasons for this drastic difference: 1) the increasing prevalence of myopia in younger age groups, and 2) the hyperopic shift associated with aging. Our cross-sectional study was not able to estimate the contribution rate of these two factors, although both may be significant. The trend of the higher prevalence of myopia in the younger age groups is supported by the fact that in 1934 the prevalence of myopia among 18-year-old schoolchildren in Hungary was found to be 10.6%, which is almost 6 times lower than the current value

. The rise in myopia in younger age groups nowadays could be attributed to children’s intensive education training, which both extends near work and reduces outdoor time

.

雷公藤內(nèi)脂醇的濃度為5時(shí)，培養(yǎng)24 h和48 h的抑制作用差異無統(tǒng)計(jì)學(xué)意義(P>0.05)；雷公藤內(nèi)脂醇濃度為10、20、40 nmol/L時(shí)，培養(yǎng)24 h和48 h的抑制作用，差異有統(tǒng)計(jì)學(xué)意義(P<0.05)；雷公藤內(nèi)脂醇的濃度為80、160 nmol/L時(shí)，培養(yǎng)24 h和48 h的抑制作用差異，明顯有統(tǒng)計(jì)學(xué)意義(P<0.05)。見表1。

Altogether, we found that a bimodal pattern represented the prevalence of myopia across various age-groups in Hungary,with a peak seen in younger age groups, those between 18 and 35y of age, and another peek seen in those older than 75y of age. A similar bimodal pattern was found in France, Germany,and a few other countries, as well

.

High myopia was found to have a low prevalence in our Hungarian sample, but the 10-fold increase found with ageing and the expected increase in the future spur the need for preventive actions, especially as there is no safe threshold for myopia in regards to its complications, related eye diseases,and associated visual impairment

. Pathologic myopic diseases,

, macular degeneration, retinal detachment, optic neuropathy, and other severe complications, may be due to the elongation of the eyeball seen in myopia. In this respect, it is important to note that elongation is not necessarily proportional to refraction but only in eyeballs with medium and high myopia

. In particular, 20.9% of cases of low myopia are due to a purely corneal origin, with no eyeball elongation;moreover, emmetropic, and even hypermetropic eyes, can be found to have elongated eyeballs, with possibility of myopic complications

.

How to Decrease the Onset of Myopia and Its Associated Visual Impairments An increase in the frequency of myopia,and the associated rise in blindness and visual impairments due to myopia, are well documented worldwide

. The growing number of younger individuals worldwide with low and high myopia spurs the need to develop and implement guidelines and programs to reduce the incidence and progression of myopia, which many countries and organisations have already done worldwide in the last decade

. The National Committee for the Prevention of Blindness in China and the International Myopia Institute have recently published their white papers on myopia and the prevention of blindness

.In New Zealand, the multidisciplinary Myopia Action Group(NZMAG) was created

, and currently, the European Society of Ophthalmology has developed a European update and guidance on myopia management

. Currently, the need for the prevention of myopia and its progression are more real, as home confinement during the coronavirus 2019 (COVID-19)outbreak might worsen the global burden of myopia

.

Limitations The present study does have some limitations.First, the Comprehensive Health Screening Program of Hungary, 2010-2020, covers a large number of cases and individuals, ranging in age from 18 to 99 years old.Participants, however, were not chosen at statistical random,but rather their inclusion was voluntary, which may have influenced the results, as individuals with complaints may be motivated to participate, while people with good vision may not

. However, we believe that the risk of sampling bias may be relatively low from an ophthalmic viewpoint for two reasons: first, about half of the program provided screening for large companies and organisations where participation rates are typically above 90%, ensuring that there is no selection bias; second, the other half of the screening program, is based on the participation of individuals from all across the country in their respective villages or towns, which are visited by screening teams. Due to the availability of 40 different types of examinations of body functions in the same place on the same day, which involves a free and immediate evaluation, the primary drive for participation in these public screenings is a person’s interest in their general health, and curiosity about what their body and its functions are like. Because ophthalmic examinations are a minor component and have no priority over other examinations, participation may be regarded as random and free of selection bias form an ophthalmic viewpoint.

Another limitation of the present study is that the refractive measurements were performed using non-cycloplegic automated refractometry which may overestimate myopia while underestimating hyperopia and emmetropia

. As the possibility of measurement error varies with age, the use of cycloplegia is generally accepted for research of children and adolescents, but it is controversial for studies of young adults,and a targeted investigation found that cycloplegia is not required in population estimates of refractive errors after the age of 20

. Many large epidemiological studies, however,have used non-cycloplegic refraction

, making our findings comparable to similar studies.

膨脹力大固然提高了防滲能力，但也會(huì)對(duì)圍巖和金屬存儲(chǔ)罐產(chǎn)生損傷(如圖1)。對(duì)于處置庫安全功能參數(shù)，TKB報(bào)告中提出緩沖材料的膨脹力應(yīng)高于2MPa，以使孔隙自行封閉，阻止微生物活動(dòng)對(duì)金屬存儲(chǔ)罐產(chǎn)生腐蝕；同時(shí)，要求緩沖材料要有足夠的剛性，具有一定的承載能力，使金屬存儲(chǔ)罐處于一個(gè)合適的位置，換句話說，緩沖材料的膨脹力不能過大，否則，裝有高放核廢料的金屬存儲(chǔ)罐因承受太大應(yīng)力而發(fā)生變形等，而且會(huì)對(duì)圍巖產(chǎn)生侵?jǐn)_[9]。

In summary, 60% of the overall population has refractive errors in Hungary. Myopia (43%) is the most common refractive error, and its prevalence is increasing significantly among younger age groups (up to 61%). A national myopia program for children must be implemented, including more time spent outdoors and less time spent doing near work, to prevent the onset of myopia. Additionally, a national screening of pre-myopes and the introduction of myopia-controlling interventions (

, low dose atropine and orthokeratology)would be beneficial to slow the progression of myopia

.

ACKNOWLEDGEMENTS

Authors’ contributions: Németh J was responsible for analyzing data, interpreting results, updating reference list and writing the report. Daiki T was responsible for extracting and analyzing data. Dankovics G and Barna I was responsible for designing the survey and conducting the data collection.Limburg H and Nagy ZZS provided feedback on the report and contributed to writing the report.

Conflicts of Interest: Németh J, None; Daiki T, None;Dankovics G, None; Barna I, None; Limburg H, None;Nagy ZZS, None.

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