Sonay Ayd?n, Erdal Karavas, Düzgün Can ?enbil

Sonay Ayd?n, Erdal Karavas, Düzgün Can ?enbil, Department of Radiology, Erzincan Binali Y?ld?r?m University Faculty of Medicine, Erzincan 24100, Turkey

Abstract We read with interest the review by Teng et al, who summarized the current approach to the diagnosis and treatment of acute appendicitis (AA). Also, the article summarizes the clinical scoring systems very effectively. In one of the previous studies conducted by our research group, we showed that the use of the Alvarado score, ultrasound and C-reactive protein values in combination provides a safe confirmation or exclusion of the diagnosis of AA. Computed tomography is particularly sensitive in detecting periappendiceal abscess,peritonitis and gangrenous changes. Computed tomography is not a good diagnostic tool in pediatric patients because of the ionizing radiation it produces.Ultrasound is a valuable diagnostic tool to differentiate AA from lymphoid hyperplasia. Presence of fluid collection in the periappendiceal and lamina propria thickness less than 1 mm are the most effective parameters in differentiating appendicitis from lymphoid hyperplasia. Although AA is the most common cause of surgical acute abdomen, it remains an important diagnostic and clinical challenge. By combining clinical scoring systems, laboratory data and appropriate imaging methods, diagnostic accuracy and adherence to treatment can be increased. Lymphoid hyperplasia and perforated appendicitis present significant diagnostic challenges in children. Additional ultrasound findings are increasingly defined to differentiate AA from these conditions.

Key Words: Acute appendicitis; Inflammation; Acute abdomen; Perforation

TO THE EDlTOR

We read with interest the review by Tenget al[1], who summarized the current approach to the diagnosis and treatment of acute appendicitis (AA). Also, the article summarizes the clinical scoring systems very effectively.

In one of the published studies of our research group, we have shown that using the Alvarado score,ultrasound (US) and C-reactive protein (CRP) levels in combination enables the confirmation or rejection of AA safely[2]. The Alvarado scoring system is one of the most commonly used methods[1].Even though the scoring system contains series of laboratory parameters, it does not contain CRP levels.Rather than using the Alvarado system or US alone, combining these methods with CRP levels will increase diagnostic accuracy.

Tenget al[1] stated that computerized tomography scans have a well-established role in evaluating AA-related complications. Computed tomography is especially sensitive for detecting periappendiceal abscess, peritonitis and gangrenous changes[1] (Figure 1). Pediatric patients are more likely to develop perforated appendicitis. Imaging is critical in diagnosing perforated appendicitis; clinical differentiation can be challenging, especially in younger children. Computed tomography is not a good diagnostic tool in pediatric patients due to the ionizing radiation it produces. According to our results, US can also be used as an effective diagnostic tool for the detection of pediatric perforated appendicitis cases. The most valuable US parameters are the detection of loculated fluid in the periappendiceal area and fluid collection in all abdominal recesses. When these parameters are combined with CRP levels, diagnostic performance can be improved[3].

Figure 1 An 87-yr-old male. Coronal (A) and axial (B) sections are shown. The appendix diameter has increased, and it appears inflamed (red arrow). The distal part of the appendix is perforated (white circle). Abscesses are seen in the periappendiceal and pericecal areas (white star).

Tenget al[1] emphasized that AA occurs when the appendiceal orifice is obstructed (for example, by lymphoid hyperplasia or fecaliths), resulting in inflammation. We have demonstrated that, in addition to causing AA, lymphoid hyperplasia can serve as a significant mimicker of AA by forming an incompressible appendix larger than 6 mm in diameter, particularly in pediatric patients. US is a valuable diagnostic tool for differentiating AA from lymphoid hyperplasia. The presence of periappendiceal fluid collection and a lamina propria thickness of less than 1 mm are the most effective parameters for differentiating appendicitis from lymphoid hyperplasia[4] (Figure 2).

Figure 2 Acute appendicitis in a 12-yr-old boy. A-B: Sonographic images taken axially (A) and longitudinally (B). The lamina propria is not discernible; C-D:For comparison, axial (C) and longitudinal (D) sonographic images of an 8-year-old girl with lymphoid hyperplasia. Note the prominent and thick lamina propria.

The portal vein can be affected from appendiceal inflammation, and thrombosis might occur[1]. In addition to complications, according to our data, portal vein hemodynamic changes can help to confirm AA diagnosis in children. In equivocal cases, detecting an increase in portal vein diameter and/or flow velocity may corroborate other clinical signs of AA[5].

To summarize, AA remains a significant diagnostic and clinical challenge despite being the most common cause of surgical acute abdomen. By combining clinical scoring systems, laboratory data and appropriate imaging methods, diagnostic accuracy and treatment adherence can be increased.Lymphoid hyperplasia and perforated appendicitis present significant diagnostic challenges in children.Additional US findings are increasingly being defined for the purpose of distinguishing AA from these entities.

FOOTNOTES

Author contributions:Ayd?n S put forward the concept; ?enbil DC was responsible for designing; Karavas E provided resources; Ayd?n S and Karavas E were responsible for supervision, did the literature search and reviewed the manuscript critically; ?enbil DC and Ayd?n S were responsible for materials and wrote the manuscript; All authors have read and approved the final manuscript.

Conflict-of-interest statement:The authors declare having no conflicts of interest.

Open-Access:This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BYNC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is noncommercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Country/Territory of origin:Turkey

ORClD number:Sonay Ayd?n 0000-0002-3812-6333; Erdal Karavas 0000-0001-6649-3256; Düzgün Can ?enbil 0000-0003-0233-7371.

S-Editor:Wu YXJ

L-Editor:Filipodia

P-Editor:Wu YXJ