INTRODUCTION

CR is the main clinical endophenotype of the refractive status.A more negative or myopic refractive error is associated with a steeper CR. Approximately 35%-95% inter-individual CR variation is associated with genetic factors

. In line with our results, among the adult Egyptian population with myopia,with the increase of myopic diopter, the cornea became steeper

. The LT is changing in one’s life. Children with myopia first showed a pattern of lens thinning, between the age of 10 and 11.5y, the lens reaching thinnest, after 18 years old, it becomes thicken until 75 years old

. The increase in LT could cause myopia drift. For example, in patients with diabetes, glucose may accumulate in the lens, with an increase in curvature and thickness and a shift toward myopia

. Shih

reported that a thinner LT can have an emmetropization effect and may be associated with increased AL, possibly playing a role in myopia progression. However, in 6-18-yearold teenagers, course myopia and lens thickening and thinning association was considered coincidental

. CCT is highly hereditary and is associated with complex eye diseases, such as glaucoma and keratoconus

. Chen

and Sun

reported that CCT was an independent factor, and was not associated with CR, ACD, AL, or refractive error. In our study,the CCT difference was not statistically significant, which was consistent with the results of Chen

’s

study.

Ocular biometric parameters are important for the evaluation of myopia. There is a strong association between ocular biometric parameters and refraction

. Based on refractive status and sex, for the main ocular biometric parameters in young adults,Sun

provided a range of reference values. However,data on ocular biometry remain scarce in medical university students. Axial length (AL) contributes to the variance in spherical equivalent (SE)

. High myopia is usually defined as an AL≥26.0 mm or an SE more than 6.0 D

. High myopia associated with cataracts, myopic glaucoma, or myopic macular degeneration is one of the leading causes of blindness,particularly in European and East Asian countries

.

為確保《意見》有效落實(shí)，云南省高院將制定具體方案，將《意見》進(jìn)一步細(xì)化分解，明確任務(wù)分工、責(zé)任部門和責(zé)任人，確保這項(xiàng)工作有人抓、有人管，有人去落實(shí)。組織一線法官認(rèn)真學(xué)習(xí)領(lǐng)會(huì)，切實(shí)把文件的精神落實(shí)到具體案件的辦理過程始終，讓人民群眾有看得見、摸得著的切身感受，努力做到讓人民群眾在每一個(gè)司法案件中感受到公平正義。加強(qiáng)對《意見》實(shí)施的督促檢查以及實(shí)施效果的跟蹤分析研判，提高對全省法院審判業(yè)務(wù)指導(dǎo)的針對性和實(shí)用性，強(qiáng)化《意見》落實(shí)效果。

(2)M=m′∪Part∪Component∪Element，其中：Part表示部件節(jié)點(diǎn)的集合，Component表示組件節(jié)點(diǎn)的集合，Element表示零件節(jié)點(diǎn)的集合。整機(jī)由多個(gè)部件組成，部件由多個(gè)組件和零件組成，組件又由多個(gè)零件組成。

SUBJECTS AND METHODS

This study adhered to the tenets of the Declaration of Helsinki and was approved by the Ethics Committee of Tianjin Medical University Eye Hospital(No.2021KY-16). Before the study, all participating students signed an informed consent form.

隨著經(jīng)濟(jì)的發(fā)展、城鎮(zhèn)化水平的提高，人們會(huì)向大城市聚集，往往伴隨著生育率的下降。比如過去廣東的生育率一直很高，但隨著城鎮(zhèn)化水平的提高，以及珠江三角洲的快速發(fā)展，越來越多的人們開始涌向深廣這些發(fā)達(dá)城市，隨之而來的就是出生率的下降。這是因?yàn)榇蟪鞘蟹績r(jià)上漲過快，生活成本更高，會(huì)帶來生育的負(fù)擔(dān)，高房價(jià)等經(jīng)濟(jì)壓力正在越來越影響人們的生育決策[4]。所以城鎮(zhèn)化的發(fā)展也會(huì)在一定程度上影響人口老齡化的進(jìn)程。

This study was conducted at Tianjin Medical University, China. From 2017 to 2020, 3895 freshman students were invited to participate in this study. Students originated from all provinces of mainland China. Undergraduates who unwilling to cooperate with examination, without successful biometric measurements (

=299), glaucoma (

=2), undergone retinal detachment surgery (

=6) or refractive surgery (

=15)were excluded. Eventually, effective ocular biometric data were obtained for 3573 (91.73%) students in this study.

The examination included distant visual acuity, ocular biometry, and non-cycloplegic refraction.An optical biometer (LENSTAR LS900, i8.2.2.0, Haag-Streit, Koeniz, Switzerland) was used to measure the central corneal thickness (CCT), AL, keratometry power (K),anterior chamber depth (ACD), and lens thickness (LT). Five repeated measurements were taken, and the average value was calculated for each parameter. Non-cycloplegic refraction was measured using an automatic refractometer (model KR 8900;Topcon, Tokyo, Japan) by professional optometrists, and after three measurements, refractive errors [spherical (S), cylinder(C), axis (A)] were recorded.

Refractive errors were classified according to SE. The SE was calculated using the following equation:SE=S+C/2. Emmetropes were defined as SE between -0.5 and +0.5 D. Myopia was defined as an SE＜-0.50 D, whereas hyperopia was defined as an SE＞0.50 D. Myopia was also classified into high, moderate, and mild myopia, based on an SE of ＜-6.00, -3.00 to -6.00, and -0.50 to -3.00 D, respectively.Different criteria were also used to define the extent of astigmatism (cylinder powers 0.50-＜0.75, 0.75-＜1.00, and≥1.00 D). Total astigmatism (TA) refers to the astigmatism of the eye as a complete ocular system. TA was the combined outcome of internal astigmatism (IA) and corneal astigmatism(CA). TA and CA were obtained from the measurement of automatic refractometer and lenstar, using the following formula IA=TA-CA. A cylinder axis of 90°±30° was defined as against-the-rule (ATR) astigmatism, a cylinder axis of 180°±30° was defined as with-the-rule (WTR) astigmatism,and cylinder axis of 31°-59° or 121°-149° was defined as oblique astigmatism. The cylinder power was expressed in the form of a negative. Corneal radius (CR) was extracted from the K value using the formula CR (mm)=1000×0.3375/K (D).The ACD was defined as the distance from the anterior lens to the corneal endothelium. The corrected lens position (LP) was defined as the sum of half of the LT, and the ACD

.

This study investigated the prevalence of refractive errors and determined the distribution of ocular biometric parameters in freshman students at Tianjin Medical University.

3.藥物不良反應(yīng)觀察：抗病毒藥物的不良反應(yīng)及耐受性影響患者的服藥依從性，進(jìn)而影響抗病毒治療的成敗，所以適時(shí)監(jiān)測并及時(shí)處理藥物的不良反應(yīng)對于提高治療效果至關(guān)重要（表 7）。

RESULTS

This study comprised 3573 [1312 (36.7%) males and 2261 (63.3%) females]students. The mean age was 18.22±0.67y (range: 15-23y).The total prevalence of hyperopia, emmetropia, myopia was 1.3%, 3.7%, 95%, and prevalence of mild myopia, moderate myopia, high myopia was 23.9%, 43.6%, and 27.5%. There was no statistically significant difference between males and females. The prevalence of myopia from 2017 to 2020 were 93.5%, 94.5%, 95.9%, and 96.2%, respectively (

=0.03). The prevalence of high myopia was 25.7%, 26.9%, and 28.6%,respectively. The prevalence of high myopia increased in the first 3 years, while the difference was not statistically significant (

=0.45; Table 1).

For myopic subjects with AL＜26 mm, the group with high myopia had a longer AL, lower CCT, andsteeper CR than the group with mild to moderate myopia.For myopic subjects with AL≥26 mm, the group with mild to moderate myopia had shorter AL, flatter CR, and thinner LT than the group with high myopia (Table 5).

Statistical Package for the Social Sciences(SPSS) statistical package version 20.0 (IBM Corporation,Armonk, NY, USA) was used to perform statistical analysis.There was no significant difference in the number, sex, and age in each year; thus, freshman students’ data from 4 consecutive years were analyzed together. For continuous variables, data are presented as mean±standard deviation (SD). Categorical variables were compared for the different groups using the Chi-squared test. Continuous variables were assessed using the analysis of variance and compared using an independent

-test.Only the right eye was analyzed.

-values were two-sided and considered significant at

＜0.05.

Astigmatism was generally set at 1.00 D as a clinically significant threshold. The most common type of TA was WTR(90.3%), followed by ATR (5.8%) and oblique astigmatism(3.9%). However, there were no significant differences between males and females (Table 3).

蘭德通過商業(yè)管理創(chuàng)新來幫助美國軍事物流實(shí)現(xiàn)現(xiàn)代化，這些研究為國防部節(jié)省了數(shù)百萬美元，同時(shí)提高了軍隊(duì)?wèi)?zhàn)斗力。

With diopters increase in myopia, the AL became longer, LT became thinner, CR became steeper, ACD became deeper, and LP became posterior(all

＜0.01). CCT did not change statistically significantly(

=0.10). Females were found to have a shorter AL, thinner CCT, smaller CR, shallower ACD, thicker lens, and more anterior LP than males (

＜0.01). SE was not statistically significant between males and females (

=0.11; Table 4).

This work describes refractive errors prevalence and ocular biometry in 3573 freshman students at Tianjin Medical University for 4 consecutive years. Our results showed that the prevalence of myopia and high myopia increased annually. Huang

reported that myopia prevalence among university students in Nanjing was 86.8%. Sun

conducted a cross-sectional study on 5060 students in Donghua University in Shanghai, a developed city in China,and observed the mean refractive error was -4.1 D and the prevalence of myopia and high myopia was 95.5% and 19.5%,respectively. Lv and Zhang

reported that the prevalence rate of myopia increased significantly from 78.5% to 84.1%in students in Weifang Medical College, with a mean age of 18.27y over a 2-year follow-up study in 2008 and 2010.The prevalence of myopia was 70.5% and 69.2% at Inner Mongolia Medical University in 2011 and 2013, which was an underdeveloped inland city in North China

. Our results were consistent with Donghua University in Shanghai and Nanjing but were significantly higher than those in Weifang Medical College and Inner Mongolia Medical University. Probably because myopia is associated with economic levels

.

Males tended to have a higher percentage of TA than females with astigmatism 0.75-＜1.00 and ≥1.0 D, females tended to have a higher percentage of CA and IA with astigmatism ≥0.75 D(Table 2).

1.3.1 冠脈造影所示IRA前向血流情況。IRA前向血流定義：TIMI 3級(jí)或TIMI2級(jí)為有前向血流；TIMI 0級(jí)或TIMI 1級(jí)為無前向血流。

DISCUSSION

According to AL, individuals with myopia were divided into two groups: AL≥26 mm and AL＜26 mm. The 36% of high myopia had AL＜26 mm, 78.9%moderate myopia, and 94.2% mild myopia had AL＜26 mm.The 64% of high myopia had AL≥26 mm. Meanwhile, 5.8%mild myopia and 21.1% moderate myopia had AL≥26 mm(Figure 1).

CA refers to astigmatism on the anterior surface. IA is difficult to measure, thus, it is usually considered to be the difference between TA and CA

. The percentage of those with TA≥0.50 D(64.8%) was lower than that of those with CA (88.1%), which is consistent with Chen

’s

results because IA usually has a compensatory association with CA. Males tended to have a higher percentage of TA than females with astigmatism≥0.75 D and ≥1.0 D; however, females tended to have a higher percentage of CA and IA with astigmatism ≥0.75 D. WTR astigmatism was the main type of astigmatism.

In our study, AL (25.28±1.24 mm) was longer than university students in Shanghai (male: 25.10±1.55 mm, female:24.74±1.49 mm)

and Anyang (24.78±1.21 mm)

. In our opinion, this was associated with higher diopter. Females had a shorter AL, thinner CCT, smaller CR, shallower ACD, thicker lens, and more anterior LP than males, which was consistent with previous studies results of young adults

, children

.With the diopters increase in myopia, the AL became longer,CR became steeper, ACD became deeper, LT became thinner,and LP became posterior, which was consistent with Anyang study results.

Myopia has become a global public health problem.Recent Meta-analyses have suggested that by 2050,approximately 49.8% of the world population will have myopia,and 9.8% of the world population will have high myopia

. In developed countries in Southeast and East Asia, the prevalence of myopia is currently 80%-90% in children completing secondary schooling (age 17-18y)

. In China, Sun

reported that in Dong Hua University in Shanghai, 19.5% and 95.5% of freshman students had high myopia and myopia,respectively, and Wang

reported that approximately 90% and 26% of high school students in eastern China had myopia and high myopia, respectively. Lv and Zhang

reported that the prevalence of myopia in medical university students increased from 78.5% to 84.1% over a 2-year followup period. Adolescent myopia, particularly among university students

, has become a marked public health problem.Astigmatism is a common type of refractive error, defined as the difference between the two principal meridians of the eyeball in refractive error

.

We divided students into groups according to AL. In 3395 students with myopia, 64% of high myopia had AL≥26 mm,but we also found that 5.8% of mild myopia and 21.1% of moderate myopia had AL≥26 mm. In myopia students with AL≥26 mm, mild and moderate myopia compared to high myopia, AL was shorter (26.51±0.46

26.87±0.70 mm),CR was larger (8.10±0.30

7.85±0.23 mm) and LT was thinner (3.39±0.19

3.45±0.19 mm;

＜0.001). The larger CR and thinner LT neutralize the longer AL and manifest mild or moderate myopia. It is known that the longer the AL,the higher the risk of fundus lesions. The axial elongation has been associated with maculopathies and resulted in degenerative changes in the retina, such as macular holes

,posterior staphyloma

, retinal pigment epithelium atrophy,and choroidal neovascularization

. The prevalence rate of myopic macular degeneration in subjects with an AL≥26 mm was higher than that in subjects with an AL＜26 mm

. Therefore,inconformity of refractive errors and ocular biometry existed in some students. Therefore, attention should be paid to the ocular biometry of myopia.

This study had some limitations. First, we may overestimate the prevalence of myopia without cycloplegia, a study showed that a mean 0.4±0.5 D hyperopic shift after cycloplegia aged 10-40y

. Hence, future studies regarding cycloplegia should be conducted. Second, the subjects were recruited from one medical university. Thus, the generalization of our findings to Chinese young adults should be cautious.

In summary, the prevalence rates of myopia, high myopia were significantly high among freshman students at Tianjin Medical University. Inconformity of refractive errors and ocular biometry existed in some students. More attention should be paid to the ocular biometry of mild and moderate myopia.

We would thank all those participants who contributed to this study.

今年A股市場震蕩回落，三大指數(shù)屢創(chuàng)階段新低，估值水平處于歷史低位。展望2019年，養(yǎng)老目標(biāo)基金、職業(yè)年金、外資等長線資金將給市場帶來更多的增量資金，有助于提高資本市場的穩(wěn)健性和有效性。

Supported by the Science & Technology Development Fund of Tianjin Education Commission for Higher Education of China (No.2018KJ056).

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