Yu-Fei Feng, Gui-Xin He,Yong-Yan Shen, Wei-Bin Qin, Ting Xiao, Li-Yan Yu,Meng-Xian Hu, Guo-Kun Zheng

1. Guangxi University of Chinese Medicine, Nanning 530299, China

2. The District of Cardiovascular Medicine, the Hospital of Guangxi University of Chinese Medicine, Nanning 530022, China

ARTICLE INFOArticle history:Received 16 Mar 2022 Received in revised form 23 Mar 2022 Accepted 6 Apr 2022 Available online 14 Apr 2022

ABSTRACTThe prevention and treatment of myocardial ischemia is a hot and difficult point in clinical research and animal experimental research in the cardiovascular field.The combined disease and syndrome animal model with the disease characteristics of Western medicine and guided by the theory of Chinese medicineto replicate the "syndrome" of Chinese medicine on the model animals by using experimental methods is an effective tool for the research of Chinese medicine. This article summarized the methoding methods and evaluation index of the animal model combined disease of coronary heart disease myocardial ischemia with cold blood stasis,phlegm and blood stasis, qi deficiency and blood stasis syndrome, kidney deficiency and blood stasis, and concluded the treatment of Traditional Chinese medicine. At the same time,it analyzed the main deficiencies of myocardial ischemia syndrome combined with animal models to provide reference for the establishment and research of related animal models.

Keywords:Myocardial ischemia Animal model Disease combination Traditional Chinese Medicine?Corresponding author: HE Gui-xin,M.D.,Chief Physician,Master Supervisor.E-mail: he_guixin@163.com.

Fund Project:National Natural Science Foundation of China(No.81960861);Funded by Guangxi Graduate Education Innovation Program(No.YCXJ2021035)