陳薇 應君芳 尋華音 王鳳

[摘要] 目的 探討基于微信平臺信息共享對頸動脈易損斑塊患者預后的影響。 方法 選取2018年6月至2020年6月我院收治的頸動脈易損斑塊患者85例作為本研究對象。采用隨機數(shù)字表法將本研究對象分為研究組43例與對照組42例。對照組患者采用他汀類藥物進行治療，研究組在對照組藥物治療的基礎上，給予基于微信信息共享的干預措施，統(tǒng)計比較干預前后各組的易損斑塊的面積大小及斑塊數(shù)量的變化情況，比較組間干預前后頸總動脈平均內(nèi)中膜厚度（IMT），比較各組干預前后的血脂變化情況。 結(jié)果 干預6個月后，兩組易損斑塊面積大小均較干預前變小，差異有統(tǒng)計學意義（P<0.05）;干預前，兩組易損斑塊面積比較，差異無統(tǒng)計學意義（P>0.05），干預6個月后，研究組易損斑塊面積小于對照組，差異有統(tǒng)計學意義（P<0.05）;干預后6個月，研究組斑塊消失數(shù)量多于對照組，差異有統(tǒng)計學意義（P<0.05）。干預6個月后，兩組IMT均較干預前降低，差異有統(tǒng)計學意義（P<0.05）;干預前，兩組IMT比較，差異無統(tǒng)計學意義（P>0.05），干預6個月后，研究組IMT低于對照組，差異有統(tǒng)計學意義（P<0.05）。干預后6個月，兩組三酰甘油（TG）、總膽固醇（TC）、低密度脂蛋白膽固醇（LDL-C）均較干預前降低，高密度脂蛋白膽固醇（HDL-C）較干預前升高，差異均有統(tǒng)計學意義（P<0.05）;干預前，兩組TG、TC、LDL-C、HDL-C比較，差異均無統(tǒng)計學意義（P>0.05）;干預后6個月，研究組TG、TC、HDL-C低于對照組，HDL-C高于對照組，差異均有統(tǒng)計學意義（P<0.05）。 結(jié)論 針對頸動脈易損斑塊患者，在藥物治療的基礎上給予基于微信信息共享的干預措施，可以改善治療效果，降低不良心血管事件的發(fā)生，值得在臨床上推廣應用。

[關鍵詞] 頸動脈易損斑塊;頸動脈粥樣斑塊;腦梗死;微信平臺;信息共享

[中圖分類號] R743.3? ? ? ? ? [文獻標識碼] B? ? ? ? ? [文章編號] 1673-9701（2021）24-0122-04

The impact of information sharing based on WeChat platform on the prognosis of patients with vulnerable carotid plaques

CHEN Wei1? ?YING? Junfang2? ?XUN Huayin3? ?WANG Feng4

1.Service Center， Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University， Taizhou? ?317000， China; 2.Department of Neurosurgery， Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University， Taizhou? ?317000， China; 3.Department of Blood Purification， Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University， Taizhou? ?317000， China; 4.Department of Neurology， Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University， Taizhou? ?317000， China

[Abstract] Objective To explore the impact of information sharing based on WeChat platform on the prognosis of patients with vulnerable carotid plaques. Methods Ninety-five patients with vulnerable carotid plaques admitted to our hospital from June 2018 to June 2020 were selected as the study objects and divided into two groups by random number table method， namely 43 cases in the study group and 42 cases in the control group. The control group was treated with statins， while the study group was given WeChat information sharing based intervention measures on the basis of the same drug treatment as the control group. The changes in the area of vulnerable plaques and the number of plaques in each group before and after the intervention were statistically compared. Meanwhile， the mean intima-media thickness （IMT） in the common carotid artery and the changes in blood lipid before and after the intervention were compared between the two groups. Results After 6 months of intervention， the areas of vulnerable plaques in the two groups were smaller than those before the intervention， with statistically significant difference（P<0.05）. Before the intervention， there was no statistically significant difference in the areas of vulnerable plaques between the two groups（P>0.05）. After 6 months of intervention， the areas of vulnerable plaques in the study group were smaller than those in the control group， with statistically significant difference（P<0.05）. During 6 months after the intervention， the number of plaques in the study group disappeared more than that in the control group， with statistically significant difference（P<0.05）. The IMT in the two groups after 6 months of intervention was lower than that before the intervention， with statistically significant difference （P<0.05）. The IMT difference between the two groups was not statistically significant before the intervention（P>0.05）. The IMT of the study group after 6 months of intervention was lower than that of the control group， with statistically significant difference（P<0.05）. The levels of triacylglycerol （TG）， total cholesterol （TC）， and low-density lipoprotein cholesterol （LDL-C） in the two groups during 6 months after the intervention were lower than those before the intervention， and high-density lipoprotein cholesterol （HDL-C） was higher than that before the intervention， all with statistically significant differences（P<0.05）.There were no statistically significant differences in TG，TC，LDL-C， and HDL-C between the two groups before the intervention（P>0.05）. During 6 months after the intervention， TG， TC， and HDL-C in the study group were lower than those in the control group， and HDL-C was higher than that in the control group，with statistically significant differences（P<0.05）. Conclusion For patients with vulnerable carotid plaques， WeChat information sharing based intervention based on drug therapy can improve the treatment effect and reduce the occurrence of adverse cardiovascular events. Therefore， it is worthy of clinical application.