吳麗娟

[摘要] 目的 探討達(dá)英-35聯(lián)合二甲雙胍治療多囊卵巢綜合征的療效。 方法 選取2019年2月至2020年2月收治的多囊卵巢綜合征患者90例，隨機(jī)分組后，對(duì)照組予以達(dá)英-35，觀察組采取達(dá)英-35聯(lián)合二甲雙胍，分析療效差異。 結(jié)果 觀察組治療后有效率（95.56%）高于對(duì)照組（82.22%），兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）;觀察組治療后TG、TC、HDL-C、LDL-C均低于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）;觀察組治療后FSH、LH、PRL、T均低于對(duì)照組，兩組比較，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）;觀察組治療后E2高于對(duì)照組;觀察組治療后HOMA-β、HOMA-IR、Vaspin、Apelin、Leptin低于對(duì)照組，兩組比較差異有統(tǒng)計(jì)學(xué)意義（P<0.05）;觀察組自然排卵率為46.67%、促排后排卵率為42.93%、自然受孕率、促排后受孕率為31.11%、總懷孕率為46.67%，均高于對(duì)照組的26.67%、88.89%、11.11%、31.11%、46.67%，兩組比較，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）;觀察組流產(chǎn)率為2.22%，低于對(duì)照組的15.56%，兩組比較，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。 結(jié)論 達(dá)英-35聯(lián)合二甲雙胍治療多囊卵巢綜合征療效良好。

[關(guān)鍵詞] 多囊卵巢綜合征;達(dá)英-35;二甲雙胍;性激素水平;胰島素抵抗

[中圖分類號(hào)] R711.75? ? ? ? ? [文獻(xiàn)標(biāo)識(shí)碼] B? ? ? ? ? [文章編號(hào)] 1673-9701（2021）24-0078-04

The clinical effect of Diane-35 combined with metformin in the treatment of polycystic ovary syndrome

WU Lijuan

Department of Obstetrics and Gynecology， Xianning Hospital of Traditional Chinese Medicine， Xianning? ?437100，? China

[Abstract] Objective To investigate the efficacy of Diane-35 combined with metformin in the treatment of polycystic ovary syndrome. Methods Ninety patients with polycystic ovary syndrome admitted from February 2019 to February 2020 were selected. After randomization， the control group received Diane-35， and the observation group took Diane-35 combined with metformin. The difference in efficacy was analyzed. Results The effective rate of the observation group （95.56%） after treatment was higher than that of the control group （82.22%）， and the difference between the two groups was statistically significant （P<0.05）. The TG， TC， HDL-C， and LDL-C in the observation group after treatment were lower than those in the control group， and the difference between the two groups was statistically significant （P<0.05）. The FSH， LH， PRL， and T after treatment in the observation group were lower than those in the control group， and the difference between the two groups was statistically significant （P<0.05）. The E2 in the observation group after treatment was higher than that in the control group; HOMA-β， HOMA-IR， Vaspin， Apelin， and Leptin in the observation group were lower than those in the control group after treatment. The difference between the two groups was statistically significant （P<0.05）. The natural ovulation rate （46.67%）， the ovulation rate after ovulation promotion （42.93%）， the natural conception rate， the pregnancy rate after ovulation promotion （31.11%）， and the total pregnancy rate （46.67%） in the observation group were all higher than those （26.67%， 88.89%， 11.11%， 31.11%. and 46.67%） in the control group. The difference between the two groups was statistically significant （P<0.05）. The abortion rate of the observation group （2.22%） was lower than that of the control group （15.56%）， and the difference between the two groups was statistically significant （P<0.05）. Conclusion Diane-35 combined with metformin has a good effect on the treatment of polycystic ovary syndrome.