,

aDepartment of Pharmaceutical Technology,Faculty of Pharmacy,Silpakorn University,Nakhon Pathom 73000, Thailand

bPharmaceutical Biopolymer Group(PBiG),Faculty of Pharmacy,Silpakorn University,Nakhon Pathom 73000, Thailand

Effect of cooling technique on physicochemical properties of ternary solid dispersion of manidipine hydrochloride prepared by melting method

Benchawan Chamsaia,b,Pornsak Sriamornsaka,b,*

aDepartment of Pharmaceutical Technology,Faculty of Pharmacy,Silpakorn University,Nakhon Pathom 73000, Thailand

bPharmaceutical Biopolymer Group(PBiG),Faculty of Pharmacy,Silpakorn University,Nakhon Pathom 73000, Thailand

A R T I C L E I N F O

Article history:

Available online 24 November 2015

Manidipine hydrochloride

Ternary solid dispersion

Solidifcation

Cooling technique

Solid dispersion is an established concept for drug solubility and bioavailability enhancement but strongly dependent on the choice of an appropriate carrier and preparation technique[1,2]. Ternary solid dispersion is one of the promising methods to increase the solubility of poorly-water soluble drug.The present work was conducted to increase the solubility of manidipine hydrochloride(MDP)using ternary solid dispersion prepared by melting and then solidifying at low temperature.The effect of cooling technique on the physicochemical properties of the developed system was investigated.

Ternary solid dispersion of MDP was prepared by melting method as described previously[3].The viscous mass was then solidifed by cooling in either ice-bath or liquid nitrogen.The dried mass was subsequently pulverized into powders and kept at?20°C until used.The physicochemical properties of the prepared solid dispersion powders were characterized by solubility test,powder X-ray diffractometry(PXRD)and differential scanning calorimeter(DSC),as shown in Fig.1.It was found that the solubility of MDP was signifcantly increased when the mass was solidifed using liquid nitrogen(150–380 folds)and ice bath (120–180 folds),compared with native MDP.PXRD revealed halo patterns with the absence of MDP characteristic peaks.DSC results also supported the results of PXRD;the absence of MDP melting peak was observed in all formulations.These results indicated that cooling by liquid nitrogen can provide the amorphous product having higher solubility than that by ice bath.

Fig.1–Solubility(A),PXRD(B),and DSC(C)of MDP and ternary solid dispersion solidifed by liquid nitrogen.

R E F E R E N C E S

[1]Leuner C,Dressman J.Improving drug solubility for oral delivery using solid dispersions.Eur J Pharm Biopharm 2000;50:47–60.

[2]Rashid R,Kim DW,Din F,et al.Effect of hydroxypropylcellulose and Tween 80 on physicochemical properties and bioavailability of ezetimibe-loaded solid dispersion.Carbohydr Polym 2015;130:26–31.

[3]Chamsai B,Sriamornsak P.Effect of drug loading and process temperature on physicochemical properties of manidipine hydrochloride solid dispersion.Adv Mater Res 2015;1060:176–179.

*E-mail address:sriamornsak_p@su.ac.th.

Peer review under responsibility of Shenyang Pharmaceutical University.

http://dx.doi.org/10.1016/j.ajps.2015.11.040

1818-0876/?2016 Production and hosting by Elsevier B.V.on behalf of Shenyang Pharmaceutical University.This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).