,Boonhoo Sritulrk,Pithi Chnvorhote, Vris Pongrkhnnon,,

aDepartment of Pharmaceutics and Industrial Pharmacy,Faculty of Pharmaceutical Sciences,Chulalongkorn University,Bangkok 10330,Thailand

bDepartment of Pharmacognosy and Pharmaceutical Botany,Faculty of Pharmaceutical Sciences, Chulalongkorn University,Bangkok 10330,Thailand

cCell-based Drug and Health Product Development Research Unit and Department of Pharmacology and Physiology,Faculty of Pharmaceutical Sciences,Chulalongkorn University,Bangkok 10330,Thailand

The potential effect of gigantol on lung cancer metastasis

Thitita Unahabhokhaa,Boonchoo Sritularakb,Pithi Chanvorachotec, Varisa Pongrakhananona,c,*

aDepartment of Pharmaceutics and Industrial Pharmacy,Faculty of Pharmaceutical Sciences,Chulalongkorn University,Bangkok 10330,Thailand

bDepartment of Pharmacognosy and Pharmaceutical Botany,Faculty of Pharmaceutical Sciences, Chulalongkorn University,Bangkok 10330,Thailand

cCell-based Drug and Health Product Development Research Unit and Department of Pharmacology and Physiology,Faculty of Pharmaceutical Sciences,Chulalongkorn University,Bangkok 10330,Thailand

A R T I C L E I N F O

Article history:

Available online 25 November 2015

Gigantol

Apoptosis

Anoikis

Migration

Lung cancer

Lung cancer has been one of the most fundamental leading causes of death within the past 10 years[1].The severity of the disease is related to the metastatic potential and aberrant apoptosis of lung cancer cells.Metastasis is the process when cancer cells transport from their original tumor site and establish a secondary tumor elsewhere.These aggressive behaviors comprise their anoikis resistance and their migrate abilities[2].The process of a programmed cell death in an attached condition is called apoptosis whereas anoikis is a cellular mortality in a detached condition.One of the most essential processes of metastasis is cell migration where cancer cells are able to migrate through their surrounding extra cellular matrix and penetrate into the blood circulating system allowing them to freely settle at a novel site.Therefore,the discoveries of new therapeutic strategies targeting metastasis process and apoptosis cell death have garnered the most interest in cancer pharmaceutical sciences.Gigantol,a bibenzyl compound extracted from Dendrobium draconis,has been a promising natural derived compound for cancer therapy due to several cytotoxic effects in cancer cells[3].This study has discovered that Gigantol exhibits a metastasis inhibiting effect through enhancing detachment-induced apoptosis and reducing migration activities as well as inducing apoptosis in lung cancer cells. This fnding has proven that Gigantol could be a potential cancer therapeutic compound that should be further developed for cancer therapy.

Acknowledgments

The authors acknowledge the fnancial support received from the 100th Anniversary Chulalongkorn University fund fordoctoral scholarship and the Ratchadapiseksomphot Endowment Fund(CU-56-384-HR),Chulalongkorn University.

Fig.1–Effects of Gigantol on lung cancer metastasis.

R E F E R E N C E S

[1]Siegel R,Ma J,Zou Z,et al.Cancer statistics,2014.CA Cancer J Clin 2014;64:9–29.

[2]Chambers AF,Groom AC,MacDonald IC.Dissemination and growth of cancer cells in metastatic sites.Nat Rev Cancer 2002;2:563–572.

[3]Klongkumnuankarn P,Busaranon K,Chanvorachote P, et al.Cytotoxic and antimigratory activities of phenolic compounds from Dendrobium brymerianum. Evid Based Complement Alternat Med 2015;2015: 350410.

*E-mail address:varisa.p@pharm.chula.ac.th.

Peer review under responsibility of Shenyang Pharmaceutical University.

http://dx.doi.org/10.1016/j.ajps.2015.11.048

1818-0876/?2016 Production and hosting by Elsevier B.V.on behalf of Shenyang Pharmaceutical University.This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).