b

aFaculty of Pharmaceutical Sciences,Burapha University,Chonburi 20131,Thailand

bDepartment of Pharmaceutical Technology,Faculty of Pharmacy,Silpakorn University,Nakorn Pathom 73000, Thailand

cDepartment of Chemical Engineering,Faculty of Engineering,Burapha University,Chonburi 20131,Thailand

Physicochemical characterization of gum from tamarind seed:Potential for pharmaceutical application

Kampanart Huanbuttaa,*,Tanikarn Sangnima,b, Wancheng Sittikijyothinc

aFaculty of Pharmaceutical Sciences,Burapha University,Chonburi 20131,Thailand

bDepartment of Pharmaceutical Technology,Faculty of Pharmacy,Silpakorn University,Nakorn Pathom 73000, Thailand

cDepartment of Chemical Engineering,Faculty of Engineering,Burapha University,Chonburi 20131,Thailand

A R T I C L E I N F O

Article history:

Available online 25 November 2015

Tamarind seed gum

Dry binder

Tablets

Diclofenac sodium

Tamarind(Tamarindus indica Linn.)is a topical plant that is generally found and planted inThailand.Application of tamarind seed gum can increase the value of tamarind and minimize the industrial waste[1].Tamarind seed gum powder offers high viscosity solution.Therefore,researchers are interested in developing tamarind seed gum as binder in formulation of diclofenac sodium tablet,prepared by dry granulation method. Physicochemical characterization result rerated that the carboxymethylation process could add carboxymethyl group in the chemical structure of crude gum[2].The success of chemical modifcation was confrmed by FTIR result as presented in Fig.1A.As illustrated in Fig.1B,the power X-ray diffractogram expressed the gum in the form of crude,and modifcation was in amorphous form.Melting point,solubility properties and viscosity of the polymer solution increased after the chemical structure modifcation.However,the disintegration time of the tablet made of the modifed gum was too long.Consequently,appropriated amount of gum powder (40–70 mg/tablet)was optimized.The result found that hardness of the tablet did not depend on gum amount[3].Increasing portion of the gum in the formulation retarded disintegration time and drug dissolution.The proper amount of the modifed gum in the formulation was 60 mg(7.61%w/w).Hardness of the tablet was 61 N with 1.99%of tablet friability. Disintegration time was over than 15 minutes and drug release reached 76%in 20 minutes.

Acknowledgments

The authors acknowledge the fnancial support received from Faculty of Pharmaceutical Sciences,Burapha University.Theassistance for laboratory work by Kanoknat Nakhonthai, Benjawan Ninwalaikul and Suebpong Eampakun is greatly appreciated.

Fig.1–FTIR(A)and powder X-ray diffractrogram(B)of tamarind gum in crude and modifcation forms.

R E F E R E N C E S

[1]Prajapati VD,Jani GK,Moradiya NG,et al.Pharmaceutical applications of various natural gums,mucilages and their modifed forms.Carbohydr Poly 2013;92:1685–1699.

[2]Spychaj T,Wilpiszewska K,Zdanowicz M.Medium and high substituted carboxymethyl starch:synthesis,characterization and application.Starke 2013;65:22–33.

[3]Deodhar UP,Paradkar AR,Purohit AP.Preliminary evaluation of leucaena leucocephala seed gum as a tablet binder.Drug Dev Ind Pharm 1998;24:577–582.

*E-mail address:kampanart@buu.ac.th.

Peer review under responsibility of Shenyang Pharmaceutical University.

http://dx.doi.org/10.1016/j.ajps.2015.11.051

1818-0876/?2016 Production and hosting by Elsevier B.V.on behalf of Shenyang Pharmaceutical University.This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).