,Stit Puttipiptkhchorn, Tsn Pitksuteepong,Srisgul Sungthongjeen,

aDepartment of Pharmaceutical Technology,Faculty of Pharmaceutical Sciences,Naresuan University, Phitsanulok 65000,Thailand

bDepartment of Manufacturing Pharmacy,Faculty of Pharmacy,Mahidol University,Bangkok 10400,Thailand

Development of curcumin foating tablets based on low density foam powder

Sakonjan Treesinchaia,Satit Puttipipatkhachornb, Tasana Pitaksuteeponga,Srisagul Sungthongjeena,*

aDepartment of Pharmaceutical Technology,Faculty of Pharmaceutical Sciences,Naresuan University, Phitsanulok 65000,Thailand

bDepartment of Manufacturing Pharmacy,Faculty of Pharmacy,Mahidol University,Bangkok 10400,Thailand

A R T I C L E I N F O

Article history:

Available online 25 November 2015

Curcumin

Floating tablets

Sustained drug release

Floating properties

The foating drug delivery system(FDDS)has become increasingly attractive system for gastroretentive dosage forms because it can prolong gastric retention time and improve drug bioavailability[1].Using low density material of polypropylene foam powder is one of the interesting approaches for FDDS development.This foating system has initial low density so it can foat immediately without lag time.In this study, curcumin was used as a model drug because it was able to inhibit the in vitro growth of Helicobacter pylori and accelerated the healing of peptic ulcer[2].Furthermore,curcumin is most stable in acidic condition[3].The curcumin foating matrix tablets based on low density foam powder can prolong the presence of curcumin in the stomach for effective treatment of peptic ulcer and avoid its degradation.

The foating matrix tablets were prepared by direct compression.Each tablet contained curcumin,matrix-forming polymers(different grades of HPMC)and polypropylene foam powder(Accurel?MP1004).All ingredients were thoroughly mixed for 10 min and compressed into tablet using a hydraulic press machine(Specac Inc.,USA)with 12.7 mm diameter fat-faced tooling at compression forces of 0.5 ton.The results showed that incorporation of polypropylene foam powder higher than 10%w/w into matrix tablet could provide immediate foatation upon contact with the dissolution medium without lag time.Additionally,foating times of all formulations were able to continuously foat over 8 hours.Since curcumin released in 0.1 N HCl was very low, 1%w/v SLS was added in the dissolution medium.Drug release of the foating tablets depended on the matrixforming polymer type.The drug release increased in the rank order of HPMC K100LV>HPMC K4M>HPMC K15M.The faster drug release was observed in the foating tablet with lower viscosity grade of HPMC(especially HPMC K100LV).The curcumin foating matrix tablets with good foating properties with sustained drug release were obtained in our study.

Fig.1–Floating properties of the foating tablets using HPMC K100LV as matrix-forming polymer with 10%w/w foam powder at 0 min(A),8 h(B)and drug release profles of the foating tablets with different type of matrix-forming polymer(C).

Acknowledgements

This work is fnancially supported by Research Funds from Naresuan University under the Offce of the Higher Education Commission(grant number R2558A025),Thailand,the Center of Excellence for Innovation in Chemistry(PERCHCIC),Offce of the Higher Education Commission,Ministry of Education and the Royal Golden Jubilee Ph.D.Program(Grant No.PHD/0096/2557)under the Thailand Research Fund (TRF).

R E F E R E N C E S

[1]Sungthongjeen S,Sriamornsak P,Puttipipatkhachorn S.Design and evaluation of foating multi-layer coated tablets based on gas formation.Eur J Pharm Biopharm 2008;69:255–263.

[2]De R,Kundu P,Swarnakar S,et al.Antimicrobial activity of curcumin against Helicobacter pylori isolates from India and during infections in mice.Antimicrob Agents Chemother 2009;53:1592–1597.

[3]Wang YJ,Pan MH,Cheng AL,et al.Stability of curcumin in buffer solutions and characterization of its degradation products.J Pharm Biomed Anal 1997;15(12):1867–1876.

*E-mail address:sungts2000@yahoo.com.

Peer review under responsibility of Shenyang Pharmaceutical University.

http://dx.doi.org/10.1016/j.ajps.2015.11.092

1818-0876/?2016 Production and hosting by Elsevier B.V.on behalf of Shenyang Pharmaceutical University.This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).