aFraunhofer Institute Applied Polymer Research(IAP),14476 Potsdam,Germany

bBeuth University Applied Sciences,13353 Berlin,Germany

Improving the bioavailability of pharmacologically active substances in pharmaceutical and cosmetic formulations

Joachim Storsberga,*,Marcel W.Laughtona,b,Martin Geyera,b, Mont Kumpugdee-Vollrathb,Christian Schmidta

aFraunhofer Institute Applied Polymer Research(IAP),14476 Potsdam,Germany

bBeuth University Applied Sciences,13353 Berlin,Germany

A R T I C L E I N F O

Article history:

Available online 23 November 2015

Drug delivery

Bioavailability

Nano carriers

Cosmeceutical

Galenicals

One and the same active ingredient can be used in different pharmaceutical applications to treat and cure diseases.Furthermore,the active ingredient can be used also in cosmetic formulations to care or aid the healing process.When applied topically via creams or lotions,they are referred as cosmeceuticals.In general,one aims to improve the bioavailability through tailored formulations and careful selection of components.An example is the use of latanoprost in ophthalmology for lowering the intraocular pressure in glaucoma patients with side effects including stimulated growth of eyelashes.Does this open up the possibility of using latanoprost for the local treatment for hair loss?

Latanoprost,when applied topically,shows a stimulating effect on the growth of eyelashes[1]and could serve as an agent against extensive hair loss.Hyaluronic acid is an active component which is selectively used against early skin aging[2]. The objective of this work was to establish surfactant stabilized cosmetic formulations and create galenicals based on latanoprost and creams based on hyaluronic acid.

Tococpherol was incorporated into lecithin based liposomes.Tocopherol served as a model substance for a lipophilic pharmacologically active ingredient.Using standard methods, such as thin-flm hydration method,followed by and ultrasound-assisted formation of liposomes[3],we createdparticles of the desired size range.Hyaluronic acid was incorporated into various cream bases and viscosities were measured at varying temperatures.Latanoprost based foam preparations were established and investigated with regard to foam stability.

Fig.1–Figure left:Left upper panel:Artistic interpretation of a liposome-based drug carrier.Right upper panel:Tissue treated with a polymer based immune-histological test.Tumor tissue is stained in brown color(specifc staining)with a blue counterstaining of the surrounding tissue(unspecifc staining).Bottom panel:Phase contrast photograph of exponentially growing carcinoma cells(HCT-116:size bar:200 μm).This fgure was previously published in ref.[3].Figure right:Different phospholipids used in liposome formulations.

Aside from liposomes,charged polymers that are able to bind and/or“complex”a drug are suitable for improving drug delivery systems as well as for the generation of new pharmaceuticals and cosmeceuticals.

Acknowledgement

The authors acknowledge fnancial support from the Fraunhofer Society through the ICON project“Drug Delivery.”

R E F E R E N C E S

[1]Sugimoto M,Sugimoto M,Uji Y.Quantitative analysis of eyelash lengthening following topical latanoprost therapy. Can J Ophthalmol 2002;37:342–345.

[2]Vetter L,Laughton MW,Schmidt C,et al.Anti-ageing creams, ingredients and their effects against early skin ageing.SOFW J 2014;140:32–39.SOFW J(English Edition)2014;140:34–9.

[3]Schmidt C,Storsberg J.Nanomaterials–tools,technology and methodology of nanotechnology based biomedical systems for diagnostics and therapy.Biomedicines 2015;3:203–223.

*E-mail:joachim.storsberg@iap.fraunhofer.de.

Peer review under responsibility of Shenyang Pharmaceutical University.

http://dx.doi.org/10.1016/j.ajps.2015.10.022

1818-0876/?2016 The Authors.Production and hosting by Elsevier B.V.on behalf of Shenyang Pharmaceutical University.This is an open access article under the CC BY-NC-ND license(http://creativecommons.org/licenses/by-nc-nd/4.0/).