Hong-jin WANG,Jing-jing LI，Hui KE，Xiao-yu XU

（1.College of Pharmaceutical Sciences&Chinese Medicine,Southwest University,Chongqing 400715,China;2.Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine,Chongqing 400715,China;3.Pharmacology of Chinese Materia Medica-the Key Discipline Constructed by the State Administration of Traditional Chinese Medicine,Chongqing 400715,China)

T2-24

Comprehensive regulation of traditional Chinese medicine on proliferation and differentiation of neural stem cells

Hong-jin WANG1,2,3,Jing-jing LI1,2,3，Hui KE1,2,3，Xiao-yu XU1,2,3

（1.College of Pharmaceutical Sciences&Chinese Medicine,Southwest University,Chongqing 400715,China;2.Chongqing Key Laboratory of New Drug Screening from Traditional Chinese Medicine,Chongqing 400715,China;3.Pharmacology of Chinese Materia Medica-the Key Discipline Constructed by the State Administration of Traditional Chinese Medicine,Chongqing 400715,China)

Since the diccovery of neural stem cells(NSCs)in the embryonic and adult mammalian central nerous system,it provided novel ideas forneurogenesis as the potential of proliferation and differentiation of NSCs.One of the ways to promote the clinical application of neural stem cells(NSCs)is searching effective methods which regulate the proliferation and differentiation.This is also a problem urgently to be solved in medical field.Plenty of earlier studies have shown that traditional chinese medicine can promote the proliferation and differentiation of NSCs by regulating the related signaling pathway in vivo and in vitro.The reports of Chinese and foreign literatures on regulating the proliferation and differentiation of neural stem cells in recent ten years and their target and signaling pathways is analyzed in this review.The traditional chinese medicine regulate proliferation and differentiation of NSCs by the signaling pathways of Notch,PI3K/Akt,Wnt/β-catenin,and GFs.And,those signaling pathways have cross-talk in the regulation progress.Moreover,some traditional Chinese medicine,such as astragalus,has a variety of active ingredients to regulate proliferation and differentiation of NSCs through different signaling pathways.However,to accelerate the clinical application of neural stem cells,the studies aboutthe proliferation and differentiation of NSCs and Chinese medicine should be further deepened,the mechanism of multiple targets and the comprehensive regulation function of traditional Chinese medicine should be clarified.

neural stem cells;proliferation;differentiation;traditional Chinese medicine;signaling pathways;cross-talk

The project supported by National Natural Science Foundation of China(81473549);and Funda?mental Research Funds for Central Universities(XDJK2017E158)

Hong-jin WANG,Tel:18680729427,E-mail：sudazxwhj@live.com