江煥峰　姬小趁　黃華文　伍婉卿

摘 要：我們發(fā)展了一種新穎、高效的鈀催化氧氣氧化的烯烴的去氫胺鹵化反應(yīng)。它提供了一種非常有價(jià)值的合成手段來(lái)構(gòu)建一系列的溴代烯胺類化合物，反應(yīng)條件比較溫和，并且具有非常好的立體選擇性和官能團(tuán)的耐受性。溴代烯胺類產(chǎn)物可以進(jìn)一步發(fā)生多樣化的轉(zhuǎn)化過(guò)程，因此，這個(gè)構(gòu)建此類物質(zhì)的方法具有非常重要的實(shí)際應(yīng)用價(jià)值。

關(guān)鍵詞：氧氣 鈀催化 鹵代烯胺

Abstract： A novel and efficient palladium-catalyzed dehydrogenative aminohalogenation of alkenes with molecular oxygen as the sole oxidant has been developed. This protocol provides a valuable synthetic tool for the assembly of a wide range of brominated enamines under mild conditions， with unprecedented stereoselectivity and exceptional functional group tolerance. This attractive route for the synthesis of brominated enamines is of great significance due to the products versatile reactivity for further transformations.This work was published in J. Am. Chem. Soc. 2013， 135， 5286.

Key Words： Molecular oxygen； Palladium-catalyzed； Brominated enamines

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